DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and CALCR

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001158209.2	Gene:	CALCR / 799	HGNCID:	1440	Length:	490	Species:	Homo sapiens

Alignment Length:	403	Identity:	124/403 - (30%)
Similarity:	204/403 - (50%)	Gaps:	61/403 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEK------- 103
            |..:..:|...:|..|||..|..|.|:...|.|...  .:|.|:..|::|...|.|.|
Human    65 YQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFP--DFDPSEKVTKYCDEKGVWFKHPENNRT 127

  Fly   104 YTNYDACAHLPAPESVPEFEVIVELPTIIYY---IGYTLSLVSLSLALIVFAYFKELR------- 158
            ::||..| :...||.:..       ..::||   :|::||:.:|.::|.:|.:|::|.
Human   128 WSNYTMC-NAFTPEKLKN-------AYVLYYLAIVGHSLSIFTLVISLGIFVFFRKLTTIFPLNW 184

  Fly   159 ---------CLRNTIHANLFFTYIMSALFWILLLSVQI-----SIRSGVGSCIALITLFHFFTLT 209
                     |.|.|:|.|:|.|||::::..|:.| |::     .:|....|| .::..||.:.:.
Human   185 KYRKALSLGCQRVTLHKNMFLTYILNSMIIIIHL-VEVVPNGELVRRDPVSC-KILHFFHQYMMA 247

  Fly   210 -NFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEIN 273
             |:||||.||:||:.|:|.....:..|...|..:|||.|.:.....|:.:::        .:..|
Human   248 CNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAV--------YFNDN 304

  Fly   274 CPWMQ-ETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPLF 337
            | |:. |||:.:|..|||.|.|::|..|||.|:.||:||:|..:..|:..|.||.||.::|:||.
Human   305 C-WLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLL 368

  Fly   338 GITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQ 402
            ||.::|....||.. ::|.::..:...|:..|||.|:..|||.|:||:..::..   |...: ||
Human   369 GIQFVVFPWRPSNK-MLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQ---WAQFK-IQ 428

  Fly   403 LNQ--NRRYTTKS 413
            .||  .||.:.:|
Human   429 WNQRWGRRPSNRS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	20/66 (30%)
		7tmB1_DH_R	126..394	CDD:320391	93/293 (32%)
		TM helix 1	129..153	CDD:320391	8/26 (31%)
		TM helix 2	162..183	CDD:320391	8/20 (40%)
		TM helix 3	197..219	CDD:320391	8/22 (36%)
		TM helix 4	238..254	CDD:320391	5/15 (33%)
		TM helix 5	279..302	CDD:320391	11/22 (50%)
		TM helix 6	327..349	CDD:320391	8/21 (38%)
		TM helix 7	356..381	CDD:320391	8/24 (33%)
CALCR	NP_001158209.2	HRM	69..137	CDD:308439	20/70 (29%)
		7tmB1_calcitonin_R	145..424	CDD:320402	94/293 (32%)
		TM helix 1	147..172	CDD:320402	8/24 (33%)
		TM helix 2	197..219	CDD:320402	9/22 (41%)
		TM helix 3	236..263	CDD:320402	11/26 (42%)
		TM helix 4	275..295	CDD:320402	5/19 (26%)
		TM helix 5	310..339	CDD:320402	14/28 (50%)
		TM helix 6	353..380	CDD:320402	11/26 (42%)
		TM helix 7	386..411	CDD:320402	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940