DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and VIPR2

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_005249618.1	Gene:	VIPR2 / 7434	HGNCID:	12695	Length:	463	Species:	Homo sapiens

Alignment Length:	414	Identity:	122/414 - (29%)
Similarity:	198/414 - (47%)	Gaps:	43/414 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEKYTNY-DACAHL-PA 115
            |...:|:|.||.....|....:.|....... |..:.|.::.|.::|..|.:.:: |||.:. |.
Human    77 CSGVWDNITCWRPANVGETVTVPCPKVFSNF-YSKAGNISKNCTSDGWSETFPDFVDACGYSDPE 140

  Fly   116 PESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALFWI 180
            .||...|.::|:   .||.:||::||:||:...|:...|::|.|.||.||.|||.::|:.|:..:
Human   141 DESKITFYILVK---AIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVL 202

  Fly   181 LLLSVQISI----------RSGVGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLR 235
            :...|..|.          .|.||..::|:.| .:..:.||||:|||||||:.|:|........
Human   203 VKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFL-QYCIMANFFWLLVEGLYLHTLLVAMLPPRRC- 265

  Fly   236 FNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTF 300
            |..|..||||.|.:.:..|..|:.........:..:.:.||       |:.:.|:...:|:|...
Human   266 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPW-------WVIRIPILISIIVNFVL 323

  Fly   301 LLRIMWVLITKLRSANT--VETRQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRA 363
            .:.|:.:|:.||.|.:.  .:..||::.||:.|:||||||:.|:|....|..   :...:.:|..
Human   324 FISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPIS---ISSKYQILFE 385

  Fly   364 VLL-STQGFSVSLFYCFLNSEVRNALRHHISTWRD-TRTIQLNQNRRYTTKSFSKGGGSPRAESM 426
            :.| |.||..|::.||||||||:..|:.   .||. ..|...:::.|....|||:.|.....:
Human   386 LCLGSFQGLVVAVLYCFLNSEVQCELKR---KWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ-- 445

  Fly   427 RPLTSYYGRGKRESCVSSATTTTL 450
                  :.||.|........|:.:
Human   446 ------FHRGSRAQSFLQTETSVI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/59 (25%)
		7tmB1_DH_R	126..394	CDD:320391	91/280 (33%)
		TM helix 1	129..153	CDD:320391	9/23 (39%)
		TM helix 2	162..183	CDD:320391	8/20 (40%)
		TM helix 3	197..219	CDD:320391	9/21 (43%)
		TM helix 4	238..254	CDD:320391	6/15 (40%)
		TM helix 5	279..302	CDD:320391	4/22 (18%)
		TM helix 6	327..349	CDD:320391	11/21 (52%)
		TM helix 7	356..381	CDD:320391	9/25 (36%)
VIPR2	XP_005249618.1	HormR	77..143	CDD:214468	16/66 (24%)
VIPR2	XP_005249618.1	7tm_2	148..396	CDD:278432	81/262 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810