DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and VIPR1

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_004615.2	Gene:	VIPR1 / 7433	HGNCID:	12694	Length:	457	Species:	Homo sapiens

Alignment Length:	417	Identity:	132/417 - (31%)
Similarity:	196/417 - (47%)	Gaps:	70/417 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQC------MDELQGIHYDSSKNAT 92
            |||.:..:|..|.|     |...:|::.|||.|.||.:.||.|      ...:||      :|.:
Human    49 QCLEEAQLENETIG-----CSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQG------RNVS 102

  Fly    93 RFCHANGTWEKYTNYDACAHL-PAPESV-----PEFEVIVELPTII-------YYIGYTLSLVSL 144
            |.|...| |         .|| |.|..:     .:...:.|..|:.       |.|||.|||.:|
Human   103 RSCTDEG-W---------THLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATL 157

  Fly   145 SLALIVFAYFKELRCLRNTIHANLFFTYIM-SALFWILLLSVQISIRS-----GVGSCIALITLF 203
            .:|..:.:.|::|.|.||.||.:||.::|: :|..:|..|::..|..|     |...|.|.:..|
Human   158 LVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFF 222

  Fly   204 HFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPE 268
            .:..:.||||:||||||||.|:..:|..:...|..|..||||.|:.|.:.|.:|:.....|...:
Human   223 QYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWD 287

  Fly   269 KYEINCP-WMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLR--SANTVETRQYRKAAKAL 330
              .||.. |       ||.:||:...:::|....:.|:.:|:.|||  .....::..|.:.|::.
Human   288 --TINSSLW-------WIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARST 343

  Fly   331 LVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTW 395
            |:||||||:.|::....|  ......:..|...|:.|.|||.|::.|||||.||:..||.....|
Human   344 LLLIPLFGVHYIMFAFFP--DNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRW 406

  Fly   396 RDTRTIQ--LNQNRRYTTKSFSKGGGS 420
            .    :|  |..|.:|...|    |||
Human   407 H----LQGVLGWNPKYRHPS----GGS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	18/65 (28%)
		7tmB1_DH_R	126..394	CDD:320391	95/283 (34%)
		TM helix 1	129..153	CDD:320391	10/30 (33%)
		TM helix 2	162..183	CDD:320391	8/21 (38%)
		TM helix 3	197..219	CDD:320391	9/21 (43%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	5/22 (23%)
		TM helix 6	327..349	CDD:320391	9/21 (43%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
VIPR1	NP_004615.2	HormR	59..128	CDD:214468	24/89 (27%)
VIPR1	NP_004615.2	7tm_2	139..384	CDD:278432	83/255 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810