DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and SCTR

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_011509923.1	Gene:	SCTR / 6344	HGNCID:	10608	Length:	445	Species:	Homo sapiens

Alignment Length:	409	Identity:	124/409 - (30%)
Similarity:	200/409 - (48%)	Gaps:	54/409 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QCLVQEHIEASTYGNDSG------HCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNAT 92
            ||| ||.....|  .|.|      .|...:|:|.|||.:..|.:..::|...|:.:   :|:|.:
Human    44 QCL-QELSREQT--GDLGTEQPVPGCEGMWDNISCWPSSVPGRMVEVECPRFLRML---TSRNGS 102

  Fly    93 RF--CHANGTWEKYTNYDACAHLPAPESVPE--FEVIVELPTIIYYIGYTLSLVSLSLALIVFAY 153
            .|  |..:|..|.:...:....:...:|..|  ...:::| .::|.:||:.|||.|.:||.:...
Human   103 LFRNCTQDGWSETFPRPNLACGVNVNDSSNEKRHSYLLKL-KVMYTVGYSSSLVMLLVALGILCA 166

  Fly   154 FKELRCLRNTIHANLFFTYIMSALFWILLLSVQISI---------RSGVGSCIALITLFHFFTLT 209
            |:.|.|.||.||.:||.::|:.||...:..:|..|.         |:|   |..::.||.:..:.
Human   167 FRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAG---CKLVMVLFQYCIMA 228

  Fly   210 NFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINC 274
            |:.|:|||||||:.|:..:|..:......:.:.|||.||:||..||:|:...        .::.|
Human   229 NYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFL--------EDVGC 285

  Fly   275 PWMQ------ETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANT--VETRQYRKAAKALL 331
            |.::      ...:.||.:|||...::||....:.|:.:|:.|||:..|  .|...|::.|::.|
Human   286 PSLRCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLARSTL 350

  Fly   332 VLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWR 396
            :|||||||.|:|....| |..:...:|..|  .|.|.||..|::.|||||.||:..::.....|
Human   351 LLIPLFGIHYIVFAFSP-EDAMEIQLFFEL--ALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQW- 411

  Fly   397 DTRTIQLNQNRRYTTKSFS 415
                 .|.:...:...|||
Human   412 -----HLREFPLHPVASFS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/61 (25%)
		7tmB1_DH_R	126..394	CDD:320391	94/284 (33%)
		TM helix 1	129..153	CDD:320391	9/23 (39%)
		TM helix 2	162..183	CDD:320391	8/20 (40%)
		TM helix 3	197..219	CDD:320391	7/21 (33%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	7/22 (32%)
		TM helix 6	327..349	CDD:320391	11/21 (52%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
SCTR	XP_011509923.1	HRM	64..126	CDD:280888	15/64 (23%)
SCTR	XP_011509923.1	7tm_2	139..389	CDD:278432	86/264 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810