DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and PTH1R

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_011532269.1	Gene:	PTH1R / 5745	HGNCID:	9608	Length:	606	Species:	Homo sapiens

Alignment Length:	503	Identity:	153/503 - (30%)
Similarity:	230/503 - (45%)	Gaps:	86/503 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QEHIEASTYGNDSGH-CLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTW 101
            :|..||.|.....|. ||.::|.|||||..|.|.:..:.|.|.:...::..  :|.|.|..||:|
Human   105 EEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKG--HAYRRCDRNGSW 167

  Fly   102 E-------KYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRC 159
            |       .:.||..|......|: .|.||...| .:||.:||::||.||::|:::.|||:.|.|
Human   168 ELVPGHNRTWANYSECVKFLTNET-REREVFDRL-GMIYTVGYSVSLASLTVAVLILAYFRRLHC 230

  Fly   160 LRNTIHANLFFTYIMSALFWILLLSVQIS---------------------------IRSGVGSCI 197
            .||.||.:||.::::.|:...:..:|..|                           ..:|...|.
Human   231 TRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCR 295

  Fly   198 ALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTW-AVAKSLT 261
            ..:|.|.:|..||::|:|||||||:.|:...|..:......:...|||.||:||..| :|..:|.
Human   296 VAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLA 360

  Fly   262 VTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANT--VETR-QY 323
            .|         .|..:...:..||.|.|:.|.:::|....:.|:.||.||||..|.  .:|| ||
Human   361 NT---------GCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQY 416

  Fly   324 RKAAKALLVLIPLFGITYLVVLAGP--SESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRN 386
            ||..|:.|||:||||:.|:|.:|.|  ..||.:..:......:..|.|||.|::.|||.|.||:.
Human   417 RKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQA 481

  Fly   387 ALRHHISTWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTTLV 451
            .::...|.|  |..:...:..|..:.|:|.|          |:.|:             |:.|.|
Human   482 EIKKSWSRW--TLALDFKRKARSGSSSYSYG----------PMVSH-------------TSVTNV 521

  Fly   452 GQHA----PLS---LHRGSNNALHTMPTLAANAMSSGSTLSVMPRAIS 492
            |...    |||   |...:.|....:|..|.....:..||...|.|::
Human   522 GPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMA 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	22/67 (33%)
		7tmB1_DH_R	126..394	CDD:320391	98/300 (33%)
		TM helix 1	129..153	CDD:320391	9/23 (39%)
		TM helix 2	162..183	CDD:320391	6/20 (30%)
		TM helix 3	197..219	CDD:320391	9/21 (43%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	6/22 (27%)
		TM helix 6	327..349	CDD:320391	12/23 (52%)
		TM helix 7	356..381	CDD:320391	8/24 (33%)
PTH1R	XP_011532269.1	HRM	118..186	CDD:280888	23/69 (33%)
PTH1R	XP_011532269.1	7tm_2	197..468	CDD:278432	91/280 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910