DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and calcrlb

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_001920035.3	Gene:	calcrlb / 567131	ZFINID:	ZDB-GENE-080924-1	Length:	466	Species:	Danio rerio

Alignment Length:	385	Identity:	120/385 - (31%)
Similarity:	190/385 - (49%)	Gaps:	36/385 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SVELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRF 94
            :.:.:|..:...:.:....|...|...:|..|||.....|..:...|.:...  .:|:|:.||:.
Zfish    47 TAQFECYQKIMKDTNHNKTDGSMCKRTWDGWLCWEYMEPGVTSAQHCPNYFD--DFDTSEVATKI 109

  Fly    95 CHANGTW-------EKYTNYDACAHLPAPESVPEFEVIVELPTIIYY---IGYTLSLVSLSLALI 149
            |..:|.|       ..::||..|    ..:|....:..:.|    ||   ||:.|||:||..:|.
Zfish   110 CTNSGHWFVHPESNRTWSNYTDC----RLKSNDHKKTALNL----YYLTLIGHGLSLISLFTSLG 166

  Fly   150 VFAYFKELRCLRNTIHANLFFTYIMSA----LFWILLLSVQISIRSGVGSCIALITLFHFFTLTN 210
            :|.|||.|.|.|.|:|.||||::::::    :|:..:.:.|....:...||...:.:.|:....|
Zfish   167 IFFYFKSLSCQRITLHKNLFFSFVLNSVITIIFFTCVANNQEVTEANPVSCKVSVFIHHYLLGCN 231

  Fly   211 FFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCP 275
            :||||.||:||:.|:|.....:......|..:|||.|.:.....|:::|.        .|..||.
Zfish   232 YFWMLCEGIYLHTLIVVAVFAEKQHLMWYYLLGWGFPLIPAFIHAISRSY--------YYNDNCW 288

  Fly   276 WMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPLFGIT 340
            ....|.:.:|..||:||.|::||.|||.|:.||||||:..:..|:..|.:|.:|.|:|:||.||.
Zfish   289 ISSNTSLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESSVYMRAVRATLILVPLLGIQ 353

  Fly   341 YLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRT 400
            ||::...| :..|...:|.....:|:..||..|:..:||.||||:..||.|   |...||
Zfish   354 YLLLPYKP-DGRLASEIFIHTTNILMHYQGLLVATIFCFFNSEVQGVLRRH---WNQYRT 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	17/66 (26%)
		7tmB1_DH_R	126..394	CDD:320391	97/274 (35%)
		TM helix 1	129..153	CDD:320391	11/26 (42%)
		TM helix 2	162..183	CDD:320391	7/24 (29%)
		TM helix 3	197..219	CDD:320391	7/21 (33%)
		TM helix 4	238..254	CDD:320391	5/15 (33%)
		TM helix 5	279..302	CDD:320391	10/22 (45%)
		TM helix 6	327..349	CDD:320391	9/21 (43%)
		TM helix 7	356..381	CDD:320391	7/24 (29%)
calcrlb	XP_001920035.3	HRM	67..132	CDD:280888	16/66 (24%)
calcrlb	XP_001920035.3	7tm_2	143..385	CDD:278432	87/254 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910