DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and calcrl

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_012825895.1	Gene:	calcrl / 549647	XenbaseID:	XB-GENE-5736126	Length:	481	Species:	Xenopus tropicalis

Alignment Length:	415	Identity:	130/415 - (31%)
Similarity:	204/415 - (49%)	Gaps:	49/415 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SVELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRF 94
            :.:.:| .|:.::....|.:...|...:|..|||...:.|.::..:|.|..|  .:|.|:..|:.
Frog    62 TAQYEC-YQKIMQEPANGKEGHFCNRTWDGWLCWGDVSAGVISEQRCPDYFQ--DFDPSEKVTKE 123

  Fly    95 CHANGTW-------EKYTNYDACAHLPAPESVPEFEVIVELPTIIYY---IGYTLSLVSLSLALI 149
            |..||.|       ..:|||..|......:        |:....:||   ||:.||:.||.::|.
Frog   124 CGKNGHWFRHPDSNRTWTNYTRCNTFTHEK--------VKTALNLYYLTIIGHGLSIASLLISLG 180

  Fly   150 VFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSV----QISIRSGVGSCIALITLFHFFTL-T 209
            :|.|||.|.|.|.|:|.||||:::.:::..|:.||.    |..:.:...|| .:....|.:.: .
Frog   181 IFFYFKNLSCQRITLHKNLFFSFVCNSIITIISLSAVANNQALVATNPVSC-KISQFIHLYLMGC 244

  Fly   210 NFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINC 274
            |:||||.||:||:.|:|.....:......|..:|||.|.:.....|||:||        .|..||
Frog   245 NYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYLLGWGFPLIPACIHAVARSL--------YYNDNC 301

  Fly   275 PWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPLFGI 339
            ....|||:.:|..||:||.|::||.|||.|:.||||||:..:..|:..|.||.:|.|:|:||.||
Frog   302 WISSETHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGI 366

  Fly   340 TYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLN 404
            .: |:.....|..:...::..:..:|:..||..|:..:||.|.||:..|:.|   |...: ||..
Frog   367 EF-VLFPWKPEGRIAEEIYDYVMHILMHYQGLLVATIFCFFNGEVQAVLKRH---WNQYK-IQFG 426

  Fly   405 ---------QNRRYTTKSFSKGGGS 420
                     ::..||..|.|:..|:
Frog   427 SSFAHSEGLRSASYTVSSISEIQGT 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	20/66 (30%)
		7tmB1_DH_R	126..394	CDD:320391	99/275 (36%)
		TM helix 1	129..153	CDD:320391	10/26 (38%)
		TM helix 2	162..183	CDD:320391	7/20 (35%)
		TM helix 3	197..219	CDD:320391	7/22 (32%)
		TM helix 4	238..254	CDD:320391	5/15 (33%)
		TM helix 5	279..302	CDD:320391	12/22 (55%)
		TM helix 6	327..349	CDD:320391	8/21 (38%)
		TM helix 7	356..381	CDD:320391	6/24 (25%)
calcrl	XP_012825895.1	HRM	81..149	CDD:367186	20/69 (29%)
		7tmB1_calcitonin_R	157..429	CDD:341343	101/285 (35%)
		TM helix 1	159..184	CDD:341343	10/24 (42%)
		TM helix 2	193..215	CDD:341343	7/21 (33%)
		TM helix 3	232..259	CDD:341343	10/26 (38%)
		TM helix 4	271..291	CDD:341343	5/19 (26%)
		TM helix 5	306..335	CDD:341343	15/28 (54%)
		TM helix 6	349..376	CDD:341343	11/27 (41%)
		TM helix 7	382..407	CDD:341343	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940