DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and adcyap1r1a

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001013462.1	Gene:	adcyap1r1a / 541315	ZFINID:	ZDB-GENE-050315-1	Length:	479	Species:	Danio rerio

Alignment Length:	465	Identity:	130/465 - (27%)
Similarity:	210/465 - (45%)	Gaps:	97/465 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ELQCLVQEHIEASTYGNDSG-HCLTQFDSILCWPRTARGTLAVLQC------MDELQGIHYDSSK 89
            |.:||  |.|......:|.. .|..::|::.||...:.|.:..:.|      |...:|:. ..|:
Zfish    36 EERCL--ERIALHDPKDDQKFECPWEWDNLTCWQAASVGDVVEVNCPELFEFMSPEEGLG-KISR 97

  Fly    90 NATRFCHANGTWEKYTNY-DACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAY 153
            |.|.|    |..|.|.:| |||.   ..|:..:.::.......:|.:||:.|||||:.|:::...
Zfish    98 NCTEF----GWSEPYPHYVDACM---TDENTTKPDMYYASVKALYTVGYSTSLVSLTTAMVILCR 155

  Fly   154 FKELRCLRNTIHANLFFTYIMSALFWILLLSVQISIRSGV--------------GSCIALITLFH 204
            |::|.|.||.||.|||.::|:.|        :.:.|:.||              ..|.|::..||
Zfish   156 FRKLHCTRNFIHMNLFVSFILRA--------ISVFIKDGVLYAEEDSDHCFVHTVGCKAVMVFFH 212

  Fly   205 FFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEK 269
            :..::|:||:.:|||||:.|:|:||..:...|..|..||||.|.:.|..|||   |.:.:.....
Zfish   213 YCVMSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTICVTIWAV---LRLHFDDSGC 274

  Fly   270 YEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRS-------------------A 315
            :::|    ..|.:.|:.:|||.|.::||....:.|:.:|:.||:|                   :
Zfish   275 WDMN----DNTALWWVIKGPVVASIMINFVLFIGIIIILVQKLQSPDIGGNESSIYLSCAQKCFS 335

  Fly   316 NTVETRQYR-----------KAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQ 369
            ...:..|:.           :.|::.|:|||||||.|.|....|.:......:  |....|.|.|
Zfish   336 EPTQAVQHSCRMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPEDFSKRERL--VFELGLGSFQ 398

  Fly   370 GFSVSLFYCFLNSEVRNALRHHISTWRDTR--TIQLNQNRRYTTKSFSKGGG------------- 419
            ||.|::.|||||.|.::.::....:|...|  .:.|.|.|..:..|....||
Zfish   399 GFVVAVLYCFLNGEAQSEIKRKWRSWTVNRYFAVDLKQQRHPSLASSGVNGGTQLSILSKSSSQI 463

  Fly   420 ---SPRAESM 426
               ||.||::
Zfish   464 RMSSPLAETV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	19/66 (29%)
		7tmB1_DH_R	126..394	CDD:320391	92/311 (30%)
		TM helix 1	129..153	CDD:320391	9/23 (39%)
		TM helix 2	162..183	CDD:320391	8/20 (40%)
		TM helix 3	197..219	CDD:320391	7/21 (33%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	8/22 (36%)
		TM helix 6	327..349	CDD:320391	11/21 (52%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
adcyap1r1a	NP_001013462.1	HRM	56..118	CDD:280888	19/69 (28%)
adcyap1r1a	NP_001013462.1	7tm_2	128..402	CDD:278432	85/290 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910