DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and Sctr

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001012322.2	Gene:	Sctr / 319229	MGIID:	2441720	Length:	464	Species:	Mus musculus

Alignment Length:	408	Identity:	123/408 - (30%)
Similarity:	196/408 - (48%)	Gaps:	37/408 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRF--CHANGTWEKYT 105
            |.:|....| |...:|::.|||.:|......:.|...|:..   |.:|.:.|  |..:|..|.:.
Mouse    71 APSYTVHQG-CERFWDNMSCWPSSALAQTVEVPCPKFLRMF---SGRNGSLFRNCTKDGWSETFP 131

  Fly   106 NYD-AC-AHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANL 168
            ..| || .::....:......:::| .::|.:||:.||..|.:||.:...|:.|.|.||.||.:|
Mouse   132 RPDLACGVNMNGSFNERRHAYLLKL-KVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHL 195

  Fly   169 FFTYIMSALFWILLLSVQI---------SIRSGVGSCIALITLFHFFTLTNFFWMLVEGLYLYML 224
            |.::|:.||...:..:|..         :.|:|   |..::..|.:..:.|:.|:|||||||:.|
Mouse   196 FVSFILRALSNFIKDAVLFPADDVTYCDAHRAG---CKLVMIFFQYCIMANYAWLLVEGLYLHTL 257

  Fly   225 VVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGP 289
            :..:|..:......:...|||.||:||..|||.:.....:..   ::||    ....:.|:.:||
Mouse   258 LAISFFSERKCLQAFVLFGWGSPAIFVALWAVTRHFLEDFGC---WDIN----SNASIWWVIRGP 315

  Fly   290 VCAVLIINLTFLLRIMWVLITKLRSANT--VETRQYRKAAKALLVLIPLFGITYLVVLAGPSESG 352
            |...::||..|.:.|:.:|:.|||:..|  .||..|::.||:.|:|||||||.|:|....| |..
Mouse   316 VILSIVINFIFFINILRILMRKLRTQETRGNETHHYKRLAKSTLLLIPLFGIHYIVFAFSP-EGA 379

  Fly   353 LMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLNQNRRYTTKSFSKG 417
            :...:|..|  .|.|.||..|::.|||||.||:..::   ..||.....:........:.|||..
Mouse   380 MEVQLFFEL--ALGSFQGLVVAVLYCFLNGEVQLEVQ---KKWRQWHLQEFPLRPVALSNSFSNA 439

  Fly   418 GGSPRAESMRPLTSYYGR 435
            ...| ..|.:..||...|
Mouse   440 TNGP-THSTKAGTSEQSR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	17/63 (27%)
		7tmB1_DH_R	126..394	CDD:320391	93/278 (33%)
		TM helix 1	129..153	CDD:320391	8/23 (35%)
		TM helix 2	162..183	CDD:320391	8/20 (40%)
		TM helix 3	197..219	CDD:320391	6/21 (29%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	7/22 (32%)
		TM helix 6	327..349	CDD:320391	12/21 (57%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
Sctr	NP_001012322.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810