DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and GIPR

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_011525011.1	Gene:	GIPR / 2696	HGNCID:	4271	Length:	508	Species:	Homo sapiens

Alignment Length:	463	Identity:	124/463 - (26%)
Similarity:	199/463 - (42%)	Gaps:	99/463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEKYTNYDACAHLPAPE 117
            |...||..:||...|....|...|...|...|:.::....|.|.::|.|..:.::..|.:....|
Human    61 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNE 125

  Fly   118 SVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILL 182
            :..:..:|:|...::|.:||:|||.:|.|||::.:.|:.|.|.||.||.|||.::::.|.  .:|
Human   126 AFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAA--AIL 188

  Fly   183 LSVQISIRSG--------------VGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDN 233
            ...::..|.|              :.:|.....:..:....|:.|:||||:||:.|:|.....:.
Human   189 SRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEE 253

  Fly   234 LRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLI--- 295
            ..|..|..:|||.|||||:.|.:.:.|.......|:.|:...|       ||.:.|:...::
Human   254 GHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIW-------WIIRTPILMTILVGS 311

  Fly   296 ---------------------------------------INLTFLLRIMWVLITKLRSANTVETR 321
                                                   ||....:||:.:|::|||: ..:..|
Human   312 VPPPPGRPQGFPILGSGLPPPPAPSEWDRGWLSPYLSPQINFLIFIRILGILLSKLRT-RQMRCR 375

  Fly   322 QYR-KAAKALLVLIPLFGITYLVVLAGPSESGLMGHM-FAVL--RAVLLSTQGFSVSLFYCFLNS 382
            .|| :.|::.|.|:||.|: :.||.|..:|....|.: ||.|  ...|.|.|||.||:.|||:|.
Human   376 DYRLRLARSTLTLVPLLGV-HEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINK 439

  Fly   383 EVRNALR---HHISTWRDTRTIQLNQNRRY-------------------TTKSFSKGG-GSPRAE 424
            ||::.:|   ||....|     .|.:.:|.                   |::..|.|. ..|..|
Human   440 EVQSEIRRGWHHCRLRR-----SLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNE 499

  Fly   425 SMRPLTSY 432
            :.|.|.||
Human   500 ASRELESY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/58 (26%)
		7tmB1_DH_R	126..394	CDD:320391	95/330 (29%)
		TM helix 1	129..153	CDD:320391	10/23 (43%)
		TM helix 2	162..183	CDD:320391	7/20 (35%)
		TM helix 3	197..219	CDD:320391	5/21 (24%)
		TM helix 4	238..254	CDD:320391	9/15 (60%)
		TM helix 5	279..302	CDD:320391	5/64 (8%)
		TM helix 6	327..349	CDD:320391	9/21 (43%)
		TM helix 7	356..381	CDD:320391	13/27 (48%)
GIPR	XP_011525011.1	HRM	58..121	CDD:280888	15/59 (25%)
GIPR	XP_011525011.1	7tm_2	134..430	CDD:278432	84/306 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810