DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dh44-R1 and Glp1r

DIOPT Version :10

Sequence 1:NP_610960.1 Gene:Dh44-R1 / 36601 FlyBaseID:FBgn0033932 Length:504 Species:Drosophila melanogaster
Sequence 2:NP_036860.2 Gene:Glp1r / 25051 RGDID:2703 Length:463 Species:Rattus norvegicus


Alignment Length:446 Identity:133/446 - (29%)
Similarity:192/446 - (43%) Gaps:102/446 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 CLTQFDSILCWPRTARGTLAVLQC-------MDELQGIHYDSSKNATRFCHANGTWEKYTNYDAC 110
            |...||...|||....|:...:.|       ...|||..|       |||.|.|.|....|    
  Rat    62 CNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVY-------RFCTAEGIWLHKDN---- 115

  Fly   111 AHLP------------APESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNT 163
            :.||            ...:.|| |.::.| .|||.:||.||..:|.:|..:...|:.|.|.||.
  Rat   116 SSLPWRDLSECEESKQGERNSPE-EQLLSL-YIIYTVGYALSFSALVIASAILVSFRHLHCTRNY 178

  Fly   164 IHANLFFTYIMSALF--------------------WILLLSVQISIRSGVGSCIALITLFHFFTL 208
            ||.|||.::|:.||.                    |..|||.|.|:     .|..:..|..:...
  Rat   179 IHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSL-----GCRLVFLLMQYCVA 238

  Fly   209 TNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEIN 273
            .|::|:||||:|||.|:..:...:...|.:|.|||||.|.|||:.|.:.|.|         ||..
  Rat   239 ANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYL---------YEDE 294

  Fly   274 CPWMQETHVDW--IYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPL 336
            ..|.:.:::::  |.:.|:...:.:|....:|::.::|.||::....:|....:.||:.|.||||
  Rat   295 GCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPL 359

  Fly   337 FGITYLVVLAGPSESGLMGHMFAVLRAVLLST-------QGFSVSLFYCFLNSEVRNALRHHIST 394
            .| |:.|:.|...:.    |....||.|.|.|       |||.|::.|||:|:||:...|   .:
  Rat   360 LG-THEVIFAFVMDE----HARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFR---KS 416

  Fly   395 WRDTRTIQLNQNR-------RYTTKSFSKGG--GSPRAESMRPLTSYYGRGKRESC 441
            |...|..:||..|       :..|.|.|.|.  ||          |.|....:.||
  Rat   417 WERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGS----------SVYAATCQNSC 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dh44-R1NP_610960.1 HRM 52..112 CDD:397086 19/65 (29%)
7tmB1_DH_R 126..394 CDD:320391 94/296 (32%)
TM helix 1 128..153 CDD:320391 10/24 (42%)
TM helix 2 162..184 CDD:320391 11/41 (27%)
TM helix 3 197..224 CDD:320391 10/26 (38%)
TM helix 4 236..256 CDD:320391 12/19 (63%)
TM helix 5 279..308 CDD:320391 4/30 (13%)
TM helix 6 322..349 CDD:320391 11/26 (42%)
TM helix 7 356..381 CDD:320391 13/31 (42%)
Glp1rNP_036860.2 HRM 59..128 CDD:397086 21/76 (28%)
7tmB1_GLP1R 141..419 CDD:341342 95/300 (32%)
TM helix 1 143..168 CDD:341342 10/25 (40%)
TM helix 2 177..199 CDD:341342 9/21 (43%)
TM helix 3 227..254 CDD:341342 10/26 (38%)
TM helix 4 266..286 CDD:341342 12/19 (63%)
TM helix 5 302..331 CDD:341342 4/28 (14%)
TM helix 6 345..372 CDD:341342 11/27 (41%)
Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220 352..355 0/2 (0%)
TM helix 7 381..406 CDD:341342 10/24 (42%)

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