DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and Gipr

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_036846.1	Gene:	Gipr / 25024	RGDID:	2689	Length:	455	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	127/438 - (28%)
Similarity:	201/438 - (45%)	Gaps:	83/438 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEKYTNYDACAHLPAPE 117
            |...||...||..||..|.|.:.|...|......::....|.|.::|.|..:.::..|.:   ||
  Rat    58 CNGSFDMYACWNYTAANTTARVSCPWYLPWYRQVAAGFVFRQCGSDGQWGSWRDHTQCEN---PE 119

  Fly   118 SVPEFE---VIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSA--- 176
            ....|:   :|:|...::|.:||:|||.:|.|||::.:.|:.|.|.||.||.|||.::::.|
  Rat   120 KNGAFQDQKLILERLQVVYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRAGAI 184

  Fly   177 -------------------LFWILLLSVQISIRSGVGSCIALITLFHFFTLTNFFWMLVEGLYLY 222
                               ..|          ...:.:|.....|..:....|:.|:||||:||:
  Rat   185 LTRDQLLPPLGPYTGNQTPTLW----------NQALAACRTAQILTQYCVGANYTWLLVEGVYLH 239

  Fly   223 MLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQ 287
            .|:|.....:...|..|..:|||.|||||:.|.:.:.|.......|:.|:...|       ||.:
  Rat   240 HLLVVVRRSEKGHFRCYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIW-------WIIR 297

  Fly   288 GPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYR------KAAKALLVLIPLFGITYLVVLA 346
            .|:...::||....:||:.:|::|||      |||.|      :.|::.|.|:||.|: :.||.|
  Rat   298 TPILITILINFLIFIRILGILVSKLR------TRQMRCPDYRLRLARSTLTLMPLLGV-HEVVFA 355

  Fly   347 GPSESGLMGHM-FAVL--RAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLNQNRR 408
            ..:|....|.: ||.|  ...|.|.|||.||:.|||:|.||::.:|      |...::|....|.
  Rat   356 PVTEEQAEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIR------RLRLSLQEQCPRP 414

  Fly   409 YTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTTLVGQHAP 456
            :.       |.:|||.   ||:|    ..:|:.:.:|..:.::  |.|
  Rat   415 HL-------GQAPRAV---PLSS----APQEAAIRNALPSGML--HVP 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	16/58 (28%)
		7tmB1_DH_R	126..394	CDD:320391	93/298 (31%)
		TM helix 1	129..153	CDD:320391	10/23 (43%)
		TM helix 2	162..183	CDD:320391	8/42 (19%)
		TM helix 3	197..219	CDD:320391	6/21 (29%)
		TM helix 4	238..254	CDD:320391	9/15 (60%)
		TM helix 5	279..302	CDD:320391	5/22 (23%)
		TM helix 6	327..349	CDD:320391	9/21 (43%)
		TM helix 7	356..381	CDD:320391	13/27 (48%)
Gipr	NP_036846.1	HRM	55..118	CDD:280888	16/62 (26%)
Gipr	NP_036846.1	7tm_2	131..385	CDD:278432	84/277 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810