DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and mthl13

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_788325.2	Gene:	mthl13 / 246395	FlyBaseID:	FBgn0050018	Length:	440	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	84/416 - (20%)
Similarity:	146/416 - (35%)	Gaps:	130/416 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CLVQEHI------------EAST---YGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGI- 83
            |..:||:            :.||   |.|:....:|.|     |.            :||:.|:
  Fly    65 CSFKEHLFRTKLDLNIRLDDNSTEALYFNNQTLLITSF-----WD------------IDEMMGLR 112

  Fly    84 --HYDSSKNATRFCHAN---GTWEKYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLV- 142
              .|...||.|.:.|::   .|.|:|..|             ..::..:.|..|:.|.:..|.:
  Fly   113 RDEYTLYKNGTIYIHSDQSIQTKEEYCFY-------------PHQIYSDFPETIWIISHKFSSIE 164

  Fly   143 ----------SLSLALIVFA---YFKELRCLRNTIHANLFFTYIMSALFWIL---LLSVQISIRS 191
                      |:...:|:|.   :.||||        |.|...:||.:|.:.   |:.:...:|.
  Fly   165 SPGAFELASGSIICYIIIFGIYLFVKELR--------NDFGKCVMSCVFCLFLDYLIWLMDELRL 221

  Fly   192 GVGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNL-RFNIYASIGWGGPALFVVTWA 255
            ....|.....:..||...|..|..:....::..:....|.:|. :|..|::..:|..|:
  Fly   222 LDDFCSLTGYIMFFFDFANSVWFSIISYCIWKKITSVVSQENRDQFVFYSTFAYGISAI------ 280

  Fly   256 VAKSLTVTYSTPEKYEINC---PWM-----QETHVD------WIY----QGPVCAVLIINLTFLL 302
               .|.:..|..:.:|.:.   .|:     ....||      |:|    ...:||:.||  .|:|
  Fly   281 ---PLGIIISINQFWEEDLRKWNWLPLVGFSRCSVDDCKRSSWVYYFVPYAIMCAINII--MFVL 340

  Fly   303 RIMWVLITKLRSANTVETRQYRKAAKALLVLIPLFGI-TYLVVLAGPSESGLMGHMFAVLRAVLL 366
            .|..::.|| |:.:.:..|..|...   .|.:..... .||:.|   ..||:||..:.::..:|:
  Fly   341 TIKHIMKTK-RNLHNLTKRPDRNET---CVTVNFLNFELYLLFL---RISGIMGVAWILIIFLLI 398

  Fly   367 STQ----------------GFSVSLF 376
            ...                ||.:.||
  Fly   399 EVNSTFWDIFGIIIQQIHYGFGIILF 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/65 (23%)
		7tmB1_DH_R	126..394	CDD:320391	62/304 (20%)
		TM helix 1	129..153	CDD:320391	7/37 (19%)
		TM helix 2	162..183	CDD:320391	5/23 (22%)
		TM helix 3	197..219	CDD:320391	4/21 (19%)
		TM helix 4	238..254	CDD:320391	3/15 (20%)
		TM helix 5	279..302	CDD:320391	9/32 (28%)
		TM helix 6	327..349	CDD:320391	4/22 (18%)
		TM helix 7	356..381	CDD:320391	5/37 (14%)
mthl13	NP_788325.2	Mth_Ecto	<49..158	CDD:299804	25/122 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840