Protein Alignment Dh44-R1 and Adcyap1r1

DIOPT Version :9

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001257508.1
• Gene: Adcyap1r1 / 24167
• RGDID: 2038
• Length: 523
• Species: Rattus norvegicus
• Alignment Length: 575
• Identity: 139/575 - (24%)
• Similarity: 232/575 - (40%)
• Gaps: 164/575 - (28%)

  Fly    21 LHNLDGIGESVELQCL--VQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQC------- 76
            :|: |.|.:..:..||  :|...:.......|..|...:|:|.||.....|.:.::.|
  Rat    20 MHS-DCIFKKEQAMCLERIQRANDLMGLNESSPGCPGMWDNITCWKPAQVGEMVLVSCPEVFRIF 83

  Fly    77 ------MDELQGIHYDSSKNAT---------RFCHANGTWEKYTNY-DACAHLP-APESVPEFEV 124
                  |.|..|....:..|:.         |.|..:|..|.:.:| |||.... .|||..:...
  Rat    84 NPDQVWMTETIGDSGFADSNSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYY 148

  Fly   125 IVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALF-----WILLLS 184
            .:.:.. :|.:||:.||.:|:.|:::...|::|.|.||.||.|||.::::.|:.     || |.:
  Rat   149 YLSVKA-LYTVGYSTSLATLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWI-LYA 211

  Fly   185 VQISIRSGVGS--CIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGP 247
            .|.|....|.:  |.|::..||:..::|:||:.:|||||:.|:|:||..:...|..|..||||.|
  Rat   212 EQDSSHCFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTP 276

  Fly   248 ALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKL 312
            .:.|..|||   |.:.:.....:::|    ..|.:.|:.:|||...:::|....:.|:.:|:.||
  Rat   277 TVCVTVWAV---LRLYFDDAGCWDMN----DSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQKL 334

  Fly   313 RSAN-----------------TVETRQ---------------------YRK-------------- 325
            :|.:                 ..:||:                     |.|
  Rat   335 QSPDMGGNESSIYLTNLRLRVPKKTREDPLPVPSDQHSPPFLSCVQKCYCKPQRAQQHSCKMSEL 399

  Fly   326 ------AAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEV 384
                  .|::.|:|||||||.|.|....|........:  |....|.|.|||.|::.|||||.||
  Rat   400 STITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERL--VFELGLGSFQGFVVAVLYCFLNGEV 462

  Fly   385 RNALRHHISTWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTT 449
            :..::....:|:      :|   ||.|..|.
  Rat   463 QAEIKRKWRSWK------VN---RYFTMDFK---------------------------------- 484

  Fly   450 LVGQHAPLSLHRGSNNALHTMPTLAANAMSSGSTLSVMPRAISPLMRQGLEENSV 504
                              |..|:||::.::.|:.||::.::.|.|....|..:::
  Rat   485 ------------------HRHPSLASSGVNGGTQLSILSKSSSQLRMSSLPADNL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	19/82 (23%)
		7tmB1_DH_R	126..394	CDD:320391	94/332 (28%)
		TM helix 1	129..153	CDD:320391	7/23 (30%)
		TM helix 2	162..183	CDD:320391	9/25 (36%)
		TM helix 3	197..219	CDD:320391	7/21 (33%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	6/22 (27%)
		TM helix 6	327..349	CDD:320391	11/21 (52%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
Adcyap1r1	NP_001257508.1	HRM	51..136	CDD:280888	19/84 (23%)
		Important for ligand binding and specificity. /evidence=ECO:0000250	124..138		5/13 (38%)
		7tm_2	149..451	CDD:278432	86/312 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810