DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and Vipr2

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_033537.1	Gene:	Vipr2 / 22355	MGIID:	107166	Length:	437	Species:	Mus musculus

Alignment Length:	462	Identity:	130/462 - (28%)
Similarity:	211/462 - (45%)	Gaps:	84/462 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SVELQCLVQEHIE-----------ASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGI 83
            |:..:|  :.|:|           .|:...:...|...:|:|.||.....|....:.|.......
Mouse    19 SIHPEC--RFHLEIQEEETKCAELLSSQTENQRACSGVWDNITCWRPADVGETVTVPCPKVFSNF 81

  Fly    84 HYDSSKNATRFCHANGTWEKYTNY-DACAHL-PAPESVPEFEVIVELPTIIYYIGYTLSLVSLSL 146
             |....|.::.|.::|..|.:.:: |||.:. |..||...|.::|:   .||.:||::||:||:.
Mouse    82 -YSRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKISFYILVK---AIYTLGYSVSLMSLTT 142

  Fly   147 ALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSVQIS----IR------SGVGSCIALIT 201
            ..|:...|::|.|.||.||.|||.::::.|:..::..||..|    :|      |.||..::|:
Mouse   143 GSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGLLRCHDQPASWVGCKLSLV- 206

  Fly   202 LFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAK-SL--TVT 263
            .|.:..:.||:|:|||||||:.|:|........ |..|..||||.|::.:..|...: ||  |..
Mouse   207 FFQYCIMANFYWLLVEGLYLHTLLVAILPPSRC-FLAYLLIGWGIPSVCIGAWTATRLSLEDTGC 270

  Fly   264 YSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANT--VETRQYRKA 326
            :.|.:.   :.||       |:.:.|:...:::|....:.|:.:|:.||.|.:.  .:..||::.
Mouse   271 WDTNDH---SIPW-------WVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRL 325

  Fly   327 AKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHH 391
            ||:.|:||||||:.|:|..|.|  .|:......:....:.|.||..|::.||||||||:..|:..
Mouse   326 AKSTLLLIPLFGVHYMVFAAFP--IGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRR 388

  Fly   392 ISTWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTTLVGQHAP 456
               ||.....|.. :|.|...|:|....                                |..:.
Mouse   389 ---WRGLCLTQAG-SRDYRLHSWSMSRN--------------------------------GSESA 417

  Fly   457 LSLHRGS 463
            |.:||||
Mouse   418 LQIHRGS 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/60 (25%)
		7tmB1_DH_R	126..394	CDD:320391	93/282 (33%)
		TM helix 1	129..153	CDD:320391	9/23 (39%)
		TM helix 2	162..183	CDD:320391	7/20 (35%)
		TM helix 3	197..219	CDD:320391	8/21 (38%)
		TM helix 4	238..254	CDD:320391	6/15 (40%)
		TM helix 5	279..302	CDD:320391	3/22 (14%)
		TM helix 6	327..349	CDD:320391	12/21 (57%)
		TM helix 7	356..381	CDD:320391	7/24 (29%)
Vipr2	NP_033537.1	HormR	47..117	CDD:214468	16/70 (23%)
Vipr2	NP_033537.1	7tm_2	122..370	CDD:278432	83/264 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810