DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and Vipr1

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_035833.2	Gene:	Vipr1 / 22354	MGIID:	109272	Length:	459	Species:	Mus musculus

Alignment Length:	462	Identity:	135/462 - (29%)
Similarity:	213/462 - (46%)	Gaps:	80/462 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ESVELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQC---MDELQGIH-YDSSK 89
            |....|||.:..:|..|.|     |...:|::.|||.|..|.:.||.|   ......|| |:.|:
Mouse    44 EKQRQQCLEEAQLENETTG-----CSKMWDNLTCWPTTPWGQVVVLDCPLIFQLFSPIHGYNISR 103

  Fly    90 NATRFCHANGTW---EKYTNYDAC-----AHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSL 146
            |    |...| |   |....:.||     |.....:...||...|:..   |.|||:|||.||.:
Mouse   104 N----CTEEG-WSQLEPGPYHIACGLNDRASSMDEQQQTEFYDAVKTG---YTIGYSLSLASLLV 160

  Fly   147 ALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSVQISIRSGVG--------SCIALITLF 203
            |:.:.:.|::|.|.||.||.:||.::|:.|.  .:.:.......:|..        ||.|.:..|
Mouse   161 AMAILSLFRKLHCTRNYIHMHLFMSFILRAT--AVFIKDMALFNNGETDHCSEASVSCKAAVVFF 223

  Fly   204 HFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPE 268
            .:..:.||||:|||||||:.|:..:|..:...|..|..||||.|::|::.|.:.:   :.:.
Mouse   224 QYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYILIGWGVPSVFIMIWTIVR---IHFE--- 282

  Fly   269 KYEINCPWMQETHVD----WIYQGPVCAVLIINLTFLLRIMWVLITKLR--SANTVETRQYRKAA 327
              :..| |  :|.::    ||.:||:...:::|....:.|:.:|:.|||  .....::..|.:.|
Mouse   283 --DFGC-W--DTIINSSLWWIIKGPILISILVNFILFICIIRILVQKLRPPDIGKNDSSPYSRLA 342

  Fly   328 KALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHI 392
            |:.|:||||||:.|::....|  ......:..|...|:.|.|||.|::.|||||.||:..||...
Mouse   343 KSTLLLIPLFGVHYVMFAFFP--DNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKW 405

  Fly   393 STWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTTLVGQHAPL 457
            ..|      .|.....:::||....|||                   :.||.:|..:::.:.:|
Mouse   406 RRW------HLQGVLGWSSKSQHPWGGS-------------------NGVSCSTQVSMLTRVSP- 444

  Fly   458 SLHRGSN 464
            |..|.|:
Mouse   445 SARRSSS 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	21/71 (30%)
		7tmB1_DH_R	126..394	CDD:320391	90/281 (32%)
		TM helix 1	129..153	CDD:320391	10/23 (43%)
		TM helix 2	162..183	CDD:320391	7/20 (35%)
		TM helix 3	197..219	CDD:320391	9/21 (43%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	6/26 (23%)
		TM helix 6	327..349	CDD:320391	10/21 (48%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
Vipr1	NP_035833.2	HormR	59..130	CDD:214468	24/80 (30%)
Vipr1	NP_035833.2	7tm_2	140..386	CDD:278432	80/263 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810