DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and Pth2r

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_644676.1	Gene:	Pth2r / 213527	MGIID:	2180917	Length:	546	Species:	Mus musculus

Alignment Length:	466	Identity:	142/466 - (30%)
Similarity:	223/466 - (47%)	Gaps:	64/466 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKN--ATRF 94
            ::||  :.:|.|.....: |:|..::|.|:||||...|.::.:.|...:    ||.:..  |.|.
Mouse    45 KMQC--ELNITAQLQEGE-GNCFPEWDGIICWPRGTVGKMSAVPCPPYV----YDFNHKGVAFRH 102

  Fly    95 CHANGTWEK-------YTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFA 152
            |..||||:.       :.||..| .|....::.:.|....| .|:|.:||::|..||::|:::..
Mouse   103 CTPNGTWDSIHGSNKTWANYSDC-FLQPDINIGKQEFFESL-YILYTVGYSISFGSLAVAILIIG 165

  Fly   153 YFKELRCLRNTIHANLFFTYIMSALFWIL---------------LLSVQISIRSGVG-------- 194
            ||:.|.|.||.||.:||.::::.|:...:               .|.:|..:::.:|
Mouse   166 YFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQ 230

  Fly   195 --SCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVA 257
              .|...:.:|.:|..||::|:|||||||:.|:..:|..|......:.|||||.||:|||.||||
Mouse   231 YVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFISIGWGFPAVFVVAWAVA 295

  Fly   258 KSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTV---E 319
            ::...        :..| |.......||||.|:.|.:.:|....|..:.||.||:...|.|   .
Mouse   296 RATLA--------DTRC-WELSAGDRWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDM 351

  Fly   320 TRQYRKAAKALLVLIPLFGITYLVVLAGP-SESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSE 383
            .:||||.||:.|||:.:||:.|:|.:..| |.|||...:.........|.|||.||:.||:.|.|
Mouse   352 RKQYRKLAKSTLVLVLVFGVHYIVFVCQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGE 416

  Fly   384 VRNALRHHISTWR---DTRTIQLNQNRRY----TTKSFSKGGGSPRAESMRPLTSYYGRGKRESC 441
            |:..::...:.|.   |.:.......:||    ||.:.|....|....|.| |....|:..:.:|
Mouse   417 VQAEVKKMWTRWNLSIDWKRAPPCGGQRYGSVLTTVTHSTSSQSQMGASTR-LVLISGKPTKNAC 480

  Fly   442 VSSATTTTLVG 452
            ....:..||.|
Mouse   481 RQIDSHVTLPG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	21/68 (31%)
		7tmB1_DH_R	126..394	CDD:320391	98/296 (33%)
		TM helix 1	129..153	CDD:320391	8/23 (35%)
		TM helix 2	162..183	CDD:320391	6/35 (17%)
		TM helix 3	197..219	CDD:320391	8/21 (38%)
		TM helix 4	238..254	CDD:320391	10/15 (67%)
		TM helix 5	279..302	CDD:320391	7/22 (32%)
		TM helix 6	327..349	CDD:320391	10/22 (45%)
		TM helix 7	356..381	CDD:320391	8/24 (33%)
Pth2r	NP_644676.1	HRM	63..125	CDD:280888	20/65 (31%)
		7tm_2	139..406	CDD:278432	91/276 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..546
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810