DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and seb-3

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_510496.1	Gene:	seb-3 / 181598	WormBaseID:	WBGene00007664	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	398	Identity:	109/398 - (27%)
Similarity:	191/398 - (47%)	Gaps:	61/398 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQC----------MDELQGIHYDSSK 89
            |...:.:|.|:|  :.|.|...||..|||.....|......|          .:|::. .|..|:
Worm    12 CQELKKLENSSY--NPGGCSVDFDKSLCWASAHIGQQMTRDCPFTFCTAIPGCEEIKD-RYMVSR 73

  Fly    90 NATRFCHANGTWEKYTNYDACAHLPAPESVPEFEVIVE---------LPTIIYYIGYTLSLVSLS 145
            |    |::.|.|:. :||..|..:     |.|:...::         |..::..:..|||.||:.
Worm    74 N----CNSMGVWQD-SNYTMCIKV-----VEEYAQCLQGFCRVCPDVLRDLVISVSLTLSFVSVI 128

  Fly   146 L---ALIVFAYFKELRCLRNTIHANL----FFTYIMSALFWILLLSVQI----------SIRSGV 193
            |   |:::|:.|..::|.|.:||.||    .|.:.:.|: |.::.:..:          .:....
Worm   129 LLVAAIVLFSIFDSIQCRRLSIHKNLATAFVFRFAVLAI-WTIVQTTNVFQDCTRLTPLPLWDYE 192

  Fly   194 GSCIALITLFHFFTLTNFFWMLVEGLYLY-MLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVA 257
            ..|.|::....:|.:.:..|||:||.:|| ...|......:..:::|.:.|||.|.:.|..||
Worm   193 WICKAILWFVIYFNVASVMWMLIEGAFLYSRFTVFAMRHSDAPWSLYLACGWGVPFVVVTAWA-- 255

  Fly   258 KSLTVTYSTPEKYEINC--PWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVET 320
              |...|.:.::....|  |:.|..|: ||..|.:.:.||:||.|||.|:.:|:.|||:.|:.|:
Worm   256 --LVHQYISSQQTNSFCWLPYAQGLHL-WILAGTMGSALIMNLIFLLMIVVILVQKLRTENSAES 317

  Fly   321 RQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVR 385
            ::..:..||.|:|:||.||:.:.:...|...   ..::.:..|:|..:||..:::.|||||||::
Worm   318 KKIWRTIKATLLLVPLLGISNIPLFYEPEHP---SSVYMLGSAILQHSQGIFIAVLYCFLNSEIQ 379

  Fly   386 NALRHHIS 393
            .||:..:|
Worm   380 GALKRQLS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	18/69 (26%)
		7tmB1_DH_R	126..394	CDD:320391	84/297 (28%)
		TM helix 1	129..153	CDD:320391	8/26 (31%)
		TM helix 2	162..183	CDD:320391	7/24 (29%)
		TM helix 3	197..219	CDD:320391	6/21 (29%)
		TM helix 4	238..254	CDD:320391	6/15 (40%)
		TM helix 5	279..302	CDD:320391	9/22 (41%)
		TM helix 6	327..349	CDD:320391	8/21 (38%)
		TM helix 7	356..381	CDD:320391	7/24 (29%)
seb-3	NP_510496.1	HRM	27..90	CDD:280888	17/68 (25%)
seb-3	NP_510496.1	7tm_4	125..367	CDD:304433	70/250 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5470
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002345
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.750