Protein Alignment Dh44-R1 and Glp1r

DIOPT Version :10

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_067307.2
• Gene: Glp1r / 14652
• MGIID: 99571
• Length: 463
• Species: Mus musculus
• Alignment Length: 438
• Identity: 129/438 - (29%)
• Similarity: 191/438 - (43%)
• Gaps: 95/438 - (21%)

  Fly    53 CLTQFDSILCWPRTARGTLAVLQC-------MDELQGIHYDSSKNATRFCHANGTWEKYTNYDAC 110
            |...||...|||....|:...:.|       ...|||..|       |||.|.|.|....|
Mouse    62 CNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVY-------RFCTAEGLWLHKDN---- 115

  Fly   111 AHLP------------APESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNT 163
            :.||            ...:.|| |.::.| .|||.:||.||..:|.:|..:...|:.|.|.||.
Mouse   116 SSLPWRDLSECEESKRGERNFPE-EQLLSL-YIIYTVGYALSFSALVIASAILVGFRHLHCTRNY 178

  Fly   164 IHANLFFTYIMSALF--------------------WILLLSVQISIRSGVGSCIALITLFHFFTL 208
            ||.|||.::|:.||.                    |..|||.|.|:     .|..:..|..:...
Mouse   179 IHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSL-----GCRLVFLLMQYCVA 238

  Fly   209 TNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEIN 273
            .|::|:||||:|||.|:..:...:...|.:|.|||||.|.|||:.|.:.|.|         ||..
Mouse   239 ANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYL---------YEDE 294

  Fly   274 CPWMQETHVDW--IYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPL 336
            ..|.:.:::::  |.:.|:...:.:|....:|::.::::||::....:|....:.||:.|.||||
Mouse   295 GCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPL 359

  Fly   337 FGITYLVVLAGPSESGLMGHMFAVLRAVLLST-------QGFSVSLFYCFLNSEVRNALRHHIST 394
            .| |:.|:.|...:.    |....||.:.|.|       ||..|::.|||:|:||:...|   ..
Mouse   360 LG-THEVIFAFVMDE----HARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQMEFR---KC 416

  Fly   395 WRDTRTIQLNQNR-------RYTTKSFSKG---GGSPRAESMRPLTSY 432
            |...|...||..|       :..|.|.|.|   |.|..|.:.:  :||
Mouse   417 WERWRLEHLNIQRDCSMKPLKCPTSSVSSGATVGSSVYAATCQ--SSY 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	19/65 (29%)
		7tmB1_DH_R	126..394	CDD:320391	91/296 (31%)
		TM helix 1	128..153	CDD:320391	10/24 (42%)
		TM helix 2	162..184	CDD:320391	11/41 (27%)
		TM helix 3	197..224	CDD:320391	10/26 (38%)
		TM helix 4	236..256	CDD:320391	12/19 (63%)
		TM helix 5	279..308	CDD:320391	4/30 (13%)
		TM helix 6	322..349	CDD:320391	11/26 (42%)
		TM helix 7	356..381	CDD:320391	11/31 (35%)
Glp1r	NP_067307.2	HRM	59..128	CDD:397086	21/76 (28%)
		7tmB1_GLP1R	141..419	CDD:341342	92/300 (31%)
		TM helix 1	143..168	CDD:341342	10/25 (40%)
		TM helix 2	177..199	CDD:341342	9/21 (43%)
		TM helix 3	227..254	CDD:341342	10/26 (38%)
		TM helix 4	266..286	CDD:341342	12/19 (63%)
		TM helix 5	302..331	CDD:341342	4/28 (14%)
		TM helix 6	345..372	CDD:341342	11/27 (41%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220	352..355		0/2 (0%)
		TM helix 7	381..406	CDD:341342	8/24 (33%)