DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and Gcgr

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_017169752.1	Gene:	Gcgr / 14527	MGIID:	99572	Length:	497	Species:	Mus musculus

Alignment Length:	414	Identity:	118/414 - (28%)
Similarity:	195/414 - (47%)	Gaps:	74/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 GIHYDSSKNATRF--CHANGTW------EKYTNYDACAHLPAPESVPEFEVIVE--------LPT 130
            |.:..::|:...|  |..:|.|      :.:.|...|       .:.:.|:.|:        ...
Mouse    98 GTYLGTTKHRLVFKRCGPDGQWVRGPRGQPWRNASQC-------QLDDEEIEVQKGVAKMYSSQQ 155

  Fly   131 IIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSA-----LFWILL-------- 182
            ::|.:||:|||.:|.|||::....::|.|.||.||.|||.::::.|     :.|:|.
Mouse   156 VMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIG 220

  Fly   183 --LSVQISIRSG-VGSCIALITLFHFFTLTNFFWMLVEGLYLY-MLVVKTFSGDNLRFNIYASIG 243
              |||.:.:..| :..|.....:..:..:.|:.|:||||:||| :|.:.||| :...|::|..||
Mouse   221 DDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFS-ERSFFSLYLGIG 284

  Fly   244 WGGPALFVVTWAVAKSLTVTYSTPEKYE-INCPWMQETHVD--WIYQGPVCAVLIINLTFLLRIM 305
            ||.|.|||:.|.|.|.|         :| :.| |....::.  ||.:.||...|:||....:.|:
Mouse   285 WGAPLLFVIPWVVVKCL---------FENVQC-WTSNDNMGFWWILRIPVFLALLINFFIFVHII 339

  Fly   306 WVLITKLRSANTVETRQYR-KAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAV----- 364
            .:|:.||| |:.:....|: :.|::.|.||||.|: :.||.|..::.    |....||:.
Mouse   340 HLLVAKLR-AHQMHYADYKFRLARSTLTLIPLLGV-HEVVFAFVTDE----HAQGTLRSTKLFFD 398

  Fly   365 --LLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLNQNRRYTTKSFSKGG---GSPRAE 424
              |.|.||..|::.|||||.||:..|......|::.:.:|..:.........:..|   |.| .|
Mouse   399 LFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDP-CE 462

  Fly   425 SMRPLTSYYGRGKRESCVSSATTT 448
            .::.:::  |......||.|..|:
Mouse   463 KLQLMSA--GSSSGTGCVPSMETS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	8/37 (22%)
		7tmB1_DH_R	126..394	CDD:320391	98/303 (32%)
		TM helix 1	129..153	CDD:320391	10/23 (43%)
		TM helix 2	162..183	CDD:320391	9/35 (26%)
		TM helix 3	197..219	CDD:320391	5/21 (24%)
		TM helix 4	238..254	CDD:320391	9/15 (60%)
		TM helix 5	279..302	CDD:320391	7/24 (29%)
		TM helix 6	327..349	CDD:320391	10/21 (48%)
		TM helix 7	356..381	CDD:320391	11/31 (35%)
Gcgr	XP_017169752.1	7tmB1_GCGR	149..429	CDD:320395	97/296 (33%)
		TM helix 1	154..178	CDD:320395	10/23 (43%)
		TM helix 2	187..208	CDD:320395	7/20 (35%)
		TM helix 3	238..260	CDD:320395	5/21 (24%)
		TM helix 4	279..295	CDD:320395	9/15 (60%)
		TM helix 5	313..336	CDD:320395	7/22 (32%)
		TM helix 6	358..383	CDD:320395	10/25 (40%)
		TM helix 7	392..417	CDD:320395	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810