Protein Alignment Dh44-R1 and CRHR2

DIOPT Version :10

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001189404.1
• Gene: CRHR2 / 1395
• HGNCID: 2358
• Length: 438
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 147/384 - (38%)
• Similarity: 215/384 - (55%)
• Gaps: 19/384 - (4%)

  Fly    33 LQCLVQEHIEA-STYGNDSG---HCLTQFDSI-LCWPRTARGTLAVLQCMDELQGIHYDSSKNAT 92
            |..|::::... .|..|.||   :|.|..|.| .||||:|.|.|....|.:...|:.|::::||.
Human    43 LWALLEQYCHTIMTLTNLSGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAY 107

  Fly    93 RFCHANGTWEKYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKEL 157
            |.|..||||....||..|..: ..:...::::...:..::.|:|:.:|:.:|..|.::|...:.:
Human   108 RECLENGTWASKINYSQCEPI-LDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSI 171

  Fly   158 RCLRNTIHANLFFTYIMSALFWILLLSVQISI-RSGVGSCIALITLFHFFTLTNFFWMLVEGLYL 221
            |||||.||.||..|:|:..:.|.||..|...: .|....|..:.|:|::|.:||||||.|||.||
Human   172 RCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYL 236

  Fly   222 YMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETH---VD 283
            :..:|.|:|.:.||..::..|||..|...:|.||:.|..         ||....|..:..   ||
Human   237 HTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY---------YENEQCWFGKEPGDLVD 292

  Fly   284 WIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVLIPLFGITYLVVLAGP 348
            :|||||:..||:||..||..|:.:|:||||::.|.||.|||||.||.|||:||.||||::....|
Human   293 YIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNP 357

  Fly   349 SESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLNQNR 407
            .|..|...||....:.|.|.|||.||:||||.|.|||:|:|.....|:|..::::...|
Human   358 GEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMAR 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	25/60 (42%)
		7tmB1_DH_R	126..394	CDD:320391	113/271 (42%)
		TM helix 1	128..153	CDD:320391	6/24 (25%)
		TM helix 2	162..184	CDD:320391	10/21 (48%)
		TM helix 3	197..224	CDD:320391	14/26 (54%)
		TM helix 4	236..256	CDD:320391	6/19 (32%)
		TM helix 5	279..308	CDD:320391	14/31 (45%)
		TM helix 6	322..349	CDD:320391	16/26 (62%)
		TM helix 7	356..381	CDD:320391	13/24 (54%)
CRHR2	NP_001189404.1	HormR	63..134	CDD:214468	25/71 (35%)
		7tmB1_CRF-R2	140..403	CDD:320562	113/271 (42%)
		TM helix 1	142..167	CDD:320562	6/24 (25%)
		TM helix 2	176..198	CDD:320562	10/21 (48%)
		TM helix 3	212..239	CDD:320562	14/26 (54%)
		TM helix 4	251..271	CDD:320562	6/19 (32%)
		TM helix 5	288..317	CDD:320562	14/28 (50%)
		TM helix 6	331..358	CDD:320562	16/26 (62%)
		TM helix 7	365..390	CDD:320562	13/24 (54%)