DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dh44-R1 and Crhr2

DIOPT Version :9

Sequence 1:NP_610960.1 Gene:Dh44-R1 / 36601 FlyBaseID:FBgn0033932 Length:504 Species:Drosophila melanogaster
Sequence 2:NP_001275547.1 Gene:Crhr2 / 12922 MGIID:894312 Length:431 Species:Mus musculus


Alignment Length:395 Identity:151/395 - (38%)
Similarity:221/395 - (55%) Gaps:18/395 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 PLLDLHNLDGIGESVELQCLVQEHIEASTYGNDSG---HCLTQFDSI-LCWPRTARGTLAVLQCM 77
            |:|.:.......:...|..|::::...:|.||.||   :|.|..|.| .|||::|.|.|....|.
Mouse    21 PVLQVAQPGQAPQDQPLWTLLEQYCHRTTTGNFSGPYTYCNTTLDQIGTCWPQSAPGALVERPCP 85

  Fly    78 DELQGIHYDSSKNATRFCHANGTWEKYTNYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLV 142
            :...||.|::::||.|.|..||||....||..|..: ..:...::::...:..|:.|:|:.:|:|
Mouse    86 EYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPI-LDDKQRKYDLHYRIALIVNYLGHCVSVV 149

  Fly   143 SLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSVQISIRSGVGS-CIALITLFHFF 206
            :|..|.::|...:.:|||||.||.||..|:|:..:.|.||..:...:..|... |..:.|:|::|
Mouse   150 ALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYF 214

  Fly   207 TLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYE 271
            .:||||||.|||.||:..:|.|:|.::||..::..|||..|...::.|||.|..         ||
Mouse   215 VVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLY---------YE 270

  Fly   272 INCPWMQETH---VDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYRKAAKALLVL 333
            ....|..:..   ||:||||||..||:||..||..|:.:|:||||::.|.||.|||||.||.|||
Mouse   271 NEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVL 335

  Fly   334 IPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDT 398
            :||.||||::....|.|..|...:|....:.|.|.|||.||:||||.|.|||.|||.....|:|.
Mouse   336 LPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDH 400

  Fly   399 RTIQL 403
            ..:::
Mouse   401 HALRV 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dh44-R1NP_610960.1 HRM 52..112 CDD:397086 25/60 (42%)
7tmB1_DH_R 126..394 CDD:320391 115/271 (42%)
TM helix 1 129..153 CDD:320391 8/23 (35%)
TM helix 2 162..183 CDD:320391 9/20 (45%)
TM helix 3 197..219 CDD:320391 11/21 (52%)
TM helix 4 238..254 CDD:320391 4/15 (27%)
TM helix 5 279..302 CDD:320391 13/25 (52%)
TM helix 6 327..349 CDD:320391 11/21 (52%)
TM helix 7 356..381 CDD:320391 12/24 (50%)
Crhr2NP_001275547.1 HormR 56..127 CDD:214468 25/71 (35%)
7tm_2 133..375 CDD:278432 102/250 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I3230
eggNOG 1 0.900 - - E1_KOG4564
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55612
Inparanoid 1 1.050 267 1.000 Inparanoid score I3020
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46870
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002345
OrthoInspector 1 1.000 - - mtm8835
orthoMCL 1 0.900 - - OOG6_103932
Panther 1 1.100 - - LDO PTHR45620
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2715
SonicParanoid 1 1.000 - - X66
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.860

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