Protein Alignment Dh44-R1 and ADCYAP1R1

DIOPT Version :10

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001186564.1
• Gene: ADCYAP1R1 / 117
• HGNCID: 242
• Length: 496
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 131/554 - (23%)
• Similarity: 229/554 - (41%)
• Gaps: 141/554 - (25%)

  Fly    17 PLLDLHNLDGIGESVELQCL--VQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDE 79
            |:....:.|.|.:..:..||  :|...|...:.:.|..|...:|:|.||.....|.:.::.|.:.
Human    16 PMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPEL 80

  Fly    80 LQGIHYD-------------SSKNA---------TRFCHANGTWEKYTNY-DACAHLPAPESVPE 121
            .:..:.|             ...|:         :|.|..:|..|.:.:| |||..........:
Human    81 FRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGD 145

  Fly   122 FEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALF-----WIL 181
            .:........:|.:||:.|||:|:.|:::...|::|.|.||.||.|||.::::.|:.     ||
Human   146 QDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWI- 209

  Fly   182 LLSVQISIRSGVGS--CIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGW 244
            |.:.|.|....:.:  |.|::..||:..::|:||:.:|||||:.|:|:||..:...|..|..|||
Human   210 LYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGW 274

  Fly   245 GGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLI 309
            |.|.:.|..||   :|.:.:.....:::|    ..|.:.|:.:|||...:::|....:.|:.:|:
Human   275 GTPTVCVTVWA---TLRLYFDDTGCWDMN----DSTALWWVIKGPVVGSIMVNFVLFIGIIVILV 332

  Fly   310 TKLRS----------------------------------ANTVETRQYRKAAKALLVLIPLFGIT 340
            .||:|                                  .:|:..|    .|::.|:|||||||.
Human   333 QKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLR----LARSTLLLIPLFGIH 393

  Fly   341 YLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQLNQ 405
            |.|....|........:  |....|.|.|||.|::.|||||.||:..::....:|:      :|
Human   394 YTVFAFSPENVSKRERL--VFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWK------VN- 449

  Fly   406 NRRYTTKSFSKGGGSPRAESMRPLTSYYGRGKRESCVSSATTTTLVGQHAPLSLHRGSNNALHTM 470
              ||....|.                                                    |..
Human   450 --RYFAVDFK----------------------------------------------------HRH 460

  Fly   471 PTLAANAMSSGSTLSVMPRAISPLMRQGLEENSV 504
            |:||::.::.|:.||::.::.|.:...||..:::
Human   461 PSLASSGVNGGTQLSILSKSSSQIRMSGLPADNL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	17/82 (21%)
		7tmB1_DH_R	126..394	CDD:320391	91/308 (30%)
		TM helix 1	128..153	CDD:320391	8/24 (33%)
		TM helix 2	162..184	CDD:320391	10/26 (38%)
		TM helix 3	197..224	CDD:320391	11/26 (42%)
		TM helix 4	236..256	CDD:320391	9/19 (47%)
		TM helix 5	279..308	CDD:320391	7/28 (25%)
		TM helix 6	322..349	CDD:320391	11/26 (42%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
ADCYAP1R1	NP_001186564.1	HRM	52..137	CDD:397086	17/84 (20%)
		7tmB1_PACAP-R1	150..445	CDD:320653	91/308 (30%)
		TM helix 1	152..177	CDD:320653	8/24 (33%)
		TM helix 2	186..208	CDD:320653	7/21 (33%)
		TM helix 3	227..254	CDD:320653	11/26 (42%)
		TM helix 4	266..286	CDD:320653	10/22 (45%)
		TM helix 5	302..331	CDD:320653	7/28 (25%)
		TM helix 6	347..402	CDD:320653	13/58 (22%)
		TM helix 7	407..432	CDD:320653	10/26 (38%)