DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and gipr

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_005157796.1	Gene:	gipr / 101885360	ZFINID:	ZDB-GENE-050516-4	Length:	514	Species:	Danio rerio

Alignment Length:	497	Identity:	141/497 - (28%)
Similarity:	220/497 - (44%)	Gaps:	93/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QCLVQEHIEASTYGNDSG-HCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKN--ATRFC 95
            :|:    ::.|:....|| .|.:.||...||......|...:.|...|.  .:|..:|  .:|.|
Zfish    39 ECI----LKISSQPTPSGLFCKSMFDMYACWTDGVPNTTVKVPCPWYLP--WHDQVRNGFVSREC 97

  Fly    96 HANGTW------EKYTNYDACAHLPAPESVPEFEVIV-ELPTIIYYIGYTLSLVSLSLALIVFAY 153
            ..:|.|      ..:.::..|......:...|.:::| ....::|.:||:|||.|||||||:...
Zfish    98 GPDGQWLTVNHSSTWRDHSQCNADGRQQIAQENQMMVLAYFRVMYTVGYSLSLASLSLALIILLI 162

  Fly   154 FKELRCLRNTIHANLFFTYIMSALFWI--------------------LLLSVQISIRSGVGSCIA 198
            |::|||.||.||.|||.::|:.|:..:                    ::||.|:     :..|..
Zfish   163 FRKLRCTRNYIHTNLFASFILRAVSILTRDALLMKDAPEFRDNKDVSIVLSDQV-----MSGCRV 222

  Fly   199 LITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVT 263
            ...|..:....|::|:|||||||:.|:|.....:|....:|..||||.|.||||.|.:.:.|
Zfish   223 AQVLMQYCVGANYYWLLVEGLYLHNLLVLMVFSENSYICVYFFIGWGTPVLFVVPWIIVRYL--- 284

  Fly   264 YSTPEKYEIN---CPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYR- 324
            |.....:|||   ..|       ||.:.|:...:::|....:||:.:||:||: |:.:....|:
Zfish   285 YENTRCWEINENMAYW-------WIIRTPILLAILVNFFIFIRIILILISKLK-AHQMRYTDYKF 341

  Fly   325 KAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLL-------STQGFSVSLFYCFLNS 382
            :.||:.|.||||.|| :.||.|..:|....|    |||.|.|       |.|||.|::.|||:|.
Zfish   342 RLAKSTLTLIPLLGI-HEVVFAVMTEEQTEG----VLRNVNLFFELFFNSFQGFLVAILYCFVNK 401

  Fly   383 EVRNALRHHISTWRDTRTIQLNQNRRYTTKSFSKGGGSPRAE-----------------SMRPLT 430
            ||::.::.....|:  ..|.:..::|.|..:....|..|:..                 |..|..
Zfish   402 EVQSEIKKKWQRWK--LGISILDDQRNTGSNTQPVGTGPQCHHDPACSPECPLDSGSQLSSDPTP 464

  Fly   431 S---YYGRGKRES---CVSSATTTTLVGQHAPLSLHRGSNNA 466
            |   :|..|.::.   |..||....:.|...|.....|...|
Zfish   465 SIQHHYHPGAKKGKAYCYISARKQVVNGLDVPALPQCGGEGA 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/67 (22%)
		7tmB1_DH_R	126..394	CDD:320391	103/299 (34%)
		TM helix 1	129..153	CDD:320391	13/23 (57%)
		TM helix 2	162..183	CDD:320391	8/40 (20%)
		TM helix 3	197..219	CDD:320391	6/21 (29%)
		TM helix 4	238..254	CDD:320391	10/15 (67%)
		TM helix 5	279..302	CDD:320391	4/22 (18%)
		TM helix 6	327..349	CDD:320391	12/21 (57%)
		TM helix 7	356..381	CDD:320391	13/31 (42%)
gipr	XP_005157796.1	HRM	52..121	CDD:280888	16/70 (23%)
gipr	XP_005157796.1	7tm_2	139..392	CDD:278432	95/273 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810