DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R1 and calcrl2

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_003201298.3	Gene:	calcrl2 / 100537117	ZFINID:	ZDB-GENE-120228-3	Length:	493	Species:	Danio rerio

Alignment Length:	499	Identity:	142/499 - (28%)
Similarity:	242/499 - (48%)	Gaps:	69/499 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDHNHIDSVNASGSDPLLDLHNLDGIGESVELQCLVQ-EHIEASTYGNDSG-HCLTQFDSILCW 63
            |.....:..:.||.||..:....:    .|.:.:|.:: .|....|   |.| :|...:|..|||
Zfish    34 MMSAEEVTDIPASSSDFKVTREEI----LSAQFECFLKIMHDPPRT---DPGPYCNRTWDGWLCW 91

  Fly    64 PRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEK-------YTNYDACAHLPAPESVPE 121
            ..:|.|| ||..|....  :.:|||:..|:.|.|:|.|.:       ::||..|:.....:
Zfish    92 GDSAPGT-AVQLCPSYF--LDFDSSEKVTKVCDADGHWFRHPESNRLWSNYTECSAYTKEK---- 149

  Fly   122 FEVIVELPTIIYY---IGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSAL-----F 178
                :::..::||   :|:.||::||.:::.:|:|||.|.|.|.|:|.|:|.::|:::.     |
Zfish   150 ----LKVTYVMYYLAMVGHVLSIISLMISISIFSYFKCLSCQRITLHKNMFTSFILNSFATIGWF 210

  Fly   179 WILLLSVQISIRSGVGSCIALITLFHFFTLTNFFWMLVEGLYLY-MLVVKTFSGDNLRFNIYASI 242
            :.::...|....|....|..|.::.|:...:|:||||.||:||: :::|..|.|:. :...|..:
Zfish   211 YFVIGEQQTRTDSSQVGCKLLASIMHYTFCSNYFWMLCEGIYLHTLIIVAVFVGEQ-QLGWYYIL 274

  Fly   243 GWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWV 307
            |||.|.:..|..|||:..         |..:..|.:.|.:.:|..||:.|.|::||.|||.|:.|
Zfish   275 GWGFPVIPAVMHAVARLF---------YHNDRCWARNTDLLYITHGPIYAALLVNLFFLLNIVRV 330

  Fly   308 LITKLRSANTVETRQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFS 372
            ||||||..:..|:..|.||.:|.::|:||.|..:::|...|: ..:...::.:...:.:..||..
Zfish   331 LITKLRVTHRTESNVYMKAVRATIILVPLLGAQFILVPLEPN-GRISRAIYELFMNIFVHFQGLL 394

  Fly   373 VSLFYCFLNSEVRNALRHHI----STWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYY 433
            |::.:||.|.||::|||..:    |.|:..|.:..:.:..|.|       .|...|:.|...:.
Zfish   395 VAVIFCFCNGEVQSALRRKLAQYRSQWKRRRLVTTDSHCNYHT-------NSSITETSRVTINL- 451

  Fly   434 GRGKRESCVSS-----ATTTTLVGQHAPLSLHRGSNNALHTMPT 472
                 |.|.|:     |.|.||.||.......|..::...|:.|
Zfish   452 -----EPCNSTEQKTHADTHTLNGQSNGTRYDRQESDNCETLQT 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	22/66 (33%)
		7tmB1_DH_R	126..394	CDD:320391	89/280 (32%)
		TM helix 1	129..153	CDD:320391	8/26 (31%)
		TM helix 2	162..183	CDD:320391	6/25 (24%)
		TM helix 3	197..219	CDD:320391	8/21 (38%)
		TM helix 4	238..254	CDD:320391	6/15 (40%)
		TM helix 5	279..302	CDD:320391	9/22 (41%)
		TM helix 6	327..349	CDD:320391	6/21 (29%)
		TM helix 7	356..381	CDD:320391	5/24 (21%)
calcrl2	XP_003201298.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910