Protein Alignment Dh44-R1 and calcrl2

DIOPT Version :10

• Sequence 1: NP_610960.1
• Gene: Dh44-R1 / 36601
• FlyBaseID: FBgn0033932
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_073795602.1
• Gene: calcrl2 / 100537117
• ZFINID: ZDB-GENE-120228-3
• Length: 492
• Species: Danio rerio
• Alignment Length: 499
• Identity: 142/499 - (28%)
• Similarity: 242/499 - (48%)
• Gaps: 69/499 - (13%)

  Fly     1 MSDHNHIDSVNASGSDPLLDLHNLDGIGESVELQCLVQ-EHIEASTYGNDSG-HCLTQFDSILCW 63
            |.....:..:.||.||..:....:    .|.:.:|.:: .|....|   |.| :|...:|..|||
Zfish    33 MMSAEEVTDIPASSSDFKVTREEI----LSAQFECFLKIMHDPPRT---DPGPYCNRTWDGWLCW 90

  Fly    64 PRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEK-------YTNYDACAHLPAPESVPE 121
            ..:|.|| ||..|....  :.:|||:..|:.|.|:|.|.:       ::||..|:.....:
Zfish    91 GDSAPGT-AVQLCPSYF--LDFDSSEKVTKVCDADGHWFRHPESNRLWSNYTECSAYTKEK---- 148

  Fly   122 FEVIVELPTIIYY---IGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSAL-----F 178
                :::..::||   :|:.||::||.:::.:|:|||.|.|.|.|:|.|:|.::|:::.     |
Zfish   149 ----LKVTYVMYYLAMVGHVLSIISLMISISIFSYFKCLSCQRITLHKNMFTSFILNSFATIGWF 209

  Fly   179 WILLLSVQISIRSGVGSCIALITLFHFFTLTNFFWMLVEGLYLY-MLVVKTFSGDNLRFNIYASI 242
            :.::...|....|....|..|.::.|:...:|:||||.||:||: :::|..|.|:. :...|..:
Zfish   210 YFVIGEQQTRTDSSQVGCKLLASIMHYTFCSNYFWMLCEGIYLHTLIIVAVFVGEQ-QLGWYYIL 273

  Fly   243 GWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWV 307
            |||.|.:..|..|||:..         |..:..|.:.|.:.:|..||:.|.|::||.|||.|:.|
Zfish   274 GWGFPVIPAVMHAVARLF---------YHNDRCWARNTDLLYITHGPIYAALLVNLFFLLNIVRV 329

  Fly   308 LITKLRSANTVETRQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFS 372
            ||||||..:..|:..|.||.:|.::|:||.|..:::|...|: ..:...::.:...:.:..||..
Zfish   330 LITKLRVTHRTESNVYMKAVRATIILVPLLGAQFILVPLEPN-GRISRAIYELFMNIFVHFQGLL 393

  Fly   373 VSLFYCFLNSEVRNALRHHI----STWRDTRTIQLNQNRRYTTKSFSKGGGSPRAESMRPLTSYY 433
            |::.:||.|.||::|||..:    |.|:..|.:..:.:..|.|       .|...|:.|...:.
Zfish   394 VAVIFCFCNGEVQSALRRKLAQYRSQWKRRRLVTTDSHCNYHT-------NSSITETSRVTINL- 450

  Fly   434 GRGKRESCVSS-----ATTTTLVGQHAPLSLHRGSNNALHTMPT 472
                 |.|.|:     |.|.||.||.......|..::...|:.|
Zfish   451 -----EPCNSTEQKTHADTHTLNGQSNGTRYDRQESDNCETLQT 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	22/66 (33%)
		7tmB1_DH_R	126..394	CDD:320391	89/280 (32%)
		TM helix 1	128..153	CDD:320391	8/27 (30%)
		TM helix 2	162..184	CDD:320391	6/26 (23%)
		TM helix 3	197..224	CDD:320391	11/27 (41%)
		TM helix 4	236..256	CDD:320391	6/19 (32%)
		TM helix 5	279..308	CDD:320391	12/28 (43%)
		TM helix 6	322..349	CDD:320391	9/26 (35%)
		TM helix 7	356..381	CDD:320391	5/24 (21%)
calcrl2	XP_073795602.1	None