DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and gcgr

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_004916426.1	Gene:	gcgr / 100487356	XenbaseID:	XB-GENE-5918476	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	436	Identity:	119/436 - (27%)
Similarity:	190/436 - (43%)	Gaps:	90/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CLTQFDSILCWPRTARGTLAVLQC-------MDELQGIHYDSSKNATRFCHANGTW-----EKYT 105
            |...||...|||.....|...:.|       :....|:.|       :.|..:|.|     ::..
Frog    54 CNRTFDRYCCWPDALPNTTVSVPCPWFLPWHLKVQHGLVY-------KHCEPDGQWAERDAQECE 111

  Fly   106 NYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFF 170
            |.|       .:...::..|.:...|:|.:||::||.:|.||..:...|.:|.|:||.||.|||.
Frog   112 NDD-------KQIEDKYFKIYDNFKIMYTVGYSVSLGTLILAFAILVGFSKLHCMRNYIHINLFA 169

  Fly   171 TYIMSALFWILLLSVQISIRSG-----------------VGSCIALITLFHFFTLTNFFWMLVEG 218
            ::|:.|:. :|:|...:..|..                 ||..:|.: |..:..:.|::|::|||
Frog   170 SFILRAVS-VLVLDTMLKTRYNENEKFEDTHLWLSSEALVGCRVAAV-LMQYGIIANYYWLMVEG 232

  Fly   219 LYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQETHVD 283
            :|||.|:|.....:...|.:|..||||.||||::.|     :.|.|:    ||....|....::.
Frog   233 IYLYNLLVLAVFSERSYFALYLCIGWGAPALFIIPW-----VAVRYT----YENTLCWSTNNNMG 288

  Fly   284 --WIYQGPVCAVLIINLTFLLRIMWVLITKLRSANTVETRQYR-KAAKALLVLIPLFGITYLVVL 345
              ||.:..|...::||....:||:.:|::|:| |:.:....|: :.||:.|.||||.||..:...
Frog   289 FWWIIRSSVLLAIVINFVIFVRIIQILVSKMR-AHQMRYTDYKFRLAKSTLTLIPLLGIHEVAFA 352

  Fly   346 AGPSESGLMGHMFAVLRAVLL-------STQGFSVSLFYCFLNSEVRNALRHHISTWRDTRTIQL 403
            ..|.|:     :...||.|.|       |.||..|::.|||:|.||::.|......|:..:.|:.
Frog   353 FLPEET-----VHGTLRLVKLFFDLFISSFQGMLVAVLYCFVNKEVQSELLKKWKRWKLGKDIKG 412

  Fly   404 NQNRRYT----------------TKSFSKGGGSPRAESMRPLTSYY 433
            .....||                ...:.||.|.||...    :.||
Frog   413 EYKHTYTQTPRVGASTVYENHKLVGCWHKGTGKPRHNG----SMYY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/70 (21%)
		7tmB1_DH_R	126..394	CDD:320391	92/294 (31%)
		TM helix 1	129..153	CDD:320391	9/23 (39%)
		TM helix 2	162..183	CDD:320391	9/20 (45%)
		TM helix 3	197..219	CDD:320391	6/21 (29%)
		TM helix 4	238..254	CDD:320391	9/15 (60%)
		TM helix 5	279..302	CDD:320391	5/24 (21%)
		TM helix 6	327..349	CDD:320391	9/21 (43%)
		TM helix 7	356..381	CDD:320391	11/31 (35%)
gcgr	XP_004916426.1	HRM	51..113	CDD:367186	13/65 (20%)
		7tmB1_GCGR	123..403	CDD:320395	93/296 (31%)
		TM helix 1	127..152	CDD:320395	9/24 (38%)
		TM helix 2	161..183	CDD:320395	10/22 (45%)
		TM helix 3	211..238	CDD:320395	10/27 (37%)
		TM helix 4	250..270	CDD:320395	11/24 (46%)
		TM helix 5	286..315	CDD:320395	7/28 (25%)
		TM helix 6	331..356	CDD:320395	9/24 (38%)
		TM helix 7	365..390	CDD:320395	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000