DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and vipr1a

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_002660843.2	Gene:	vipr1a / 100334247	ZFINID:	ZDB-GENE-070912-506	Length:	440	Species:	Danio rerio

Alignment Length:	426	Identity:	123/426 - (28%)
Similarity:	210/426 - (49%)	Gaps:	41/426 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SDPLLDLHNLDGIGESVELQ-CLVQEHIEA------STYGNDSGHCLTQFDSILCWPRTARGTLA 72
            |..:|.|:....:|..:.:| |.|...:||      |...|.:..|..::| :.|||....|.:.
Zfish     4 SKQMLILYLTCSLGPMLSVQMCEVMWELEAEKRECLSKLENITSGCTGEWD-LACWPSARIGEVV 67

  Fly    73 VLQCMDELQGIHYDSSKNATRFCHANGTWEKYTN----YDACAHLPAPESVPEFEVIVELPTII- 132
            .:.|.:....:. |...|.::.|.|:| |.:..:    |: |.:.|   ::.|...:.|..:.:
Zfish    68 TIPCPNYFSHVS-DQIGNISKSCTADG-WTEINSVVVAYN-CGYDP---NITEDGNMGEFLSSVR 126

  Fly   133 --YYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFFTYIMSALFWILLLSVQISIRS---- 191
              |.||:|:||:||.:|:|:..:|::|.|.||.||.:||.::|:.|:..|:...|...:..
Zfish   127 TGYTIGHTVSLISLIIAIIILCFFRKLHCTRNYIHIHLFMSFILKAVAVIMKDVVLYEVEEPDDC 191

  Fly   192 --GVGSCIALITLFHFFTLTNFFWMLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTW 254
              |...|.|.:..|.:..:.:|||:|||||||:.|:..:|..:...|..|..||||.|.:|:..|
Zfish   192 HYGSVGCKAAMVFFQYGVMASFFWLLVEGLYLHALLAVSFFSERKYFWWYILIGWGVPGVFITIW 256

  Fly   255 AVAKSLTVTYSTPEKYEINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIMWVLITKL--RSANT 317
            ::.|:..        ::|.|....:..:.||.:.|....:::|....:.|:.:|..|:  |....
Zfish   257 SITKAYL--------HDIGCWDFIDDDLWWIIKTPTLITILMNFILFICIIRILRQKISCRDIGR 313

  Fly   318 VETRQYRKAAKALLVLIPLFGITYLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNS 382
            .|:.||.:.||:.|:|||||||.|::....|..  :..::..|...:|.|.|||.|::.|||||.
Zfish   314 NESHQYSRLAKSTLLLIPLFGINYIIFAFMPHH--IQSYIRLVFDLILGSFQGFCVAVLYCFLNG 376

  Fly   383 EVRNALRHHISTWRDTRTIQLNQNRRYTTKSFSKGG 418
            ||::.::.....|...|.  |..:.:|...|.:..|
Zfish   377 EVQSEIKRKWRRWHMQRF--LGADTKYHQPSTASNG 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	15/63 (24%)
		7tmB1_DH_R	126..394	CDD:320391	89/278 (32%)
		TM helix 1	129..153	CDD:320391	10/26 (38%)
		TM helix 2	162..183	CDD:320391	8/20 (40%)
		TM helix 3	197..219	CDD:320391	8/21 (38%)
		TM helix 4	238..254	CDD:320391	7/15 (47%)
		TM helix 5	279..302	CDD:320391	4/22 (18%)
		TM helix 6	327..349	CDD:320391	11/21 (52%)
		TM helix 7	356..381	CDD:320391	10/24 (42%)
vipr1a	XP_002660843.2	HRM	46..>96	CDD:280888	13/52 (25%)
vipr1a	XP_002660843.2	7tm_2	122..367	CDD:278432	80/254 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810