DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R1 and ghrhr2

DIOPT Version :9

Sequence 1:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001106975.1	Gene:	ghrhr2 / 100002189	ZFINID:	ZDB-GENE-121214-194	Length:	411	Species:	Danio rerio

Alignment Length:	385	Identity:	132/385 - (34%)
Similarity:	200/385 - (51%)	Gaps:	39/385 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ELQCLVQEHIEASTYGNDSGHCLTQFDSILCWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCH 96
            |.:|||:..: .:..|.::| ||.::|.:.|||..:.|....:.|...|:     |.:..:|.|.
Zfish    36 EAECLVKMSL-LNINGTNAG-CLVEWDGVNCWPAVSVGERVSVSCPPLLK-----SHELISRTCT 93

  Fly    97 ANGTWEKYT--NYDACAHLPAPES-----VPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYF 154
            :.| |...:  .|.||....:.|.     :.|:...|:|   ||.:||.:||.||.:|:.:|..|
Zfish    94 SKG-WSNMSVPYYIACFQDNSTEEEEIGHISEYFARVKL---IYTVGYGMSLSSLCIAVFIFCIF 154

  Fly   155 KELRCLRNTIHANLFFTYIMSALFWIL---LLSVQISIRSGVGS---CIALITLFHFFTLTNFFW 213
            ::|.|.|..||.|||.|:|:.||...:   :|....::.....|   |.|.:|.|.:..|:||:|
Zfish   155 RKLLCTRIYIHLNLFSTFILRALAVFVKDAVLFADETVNHCTVSTVLCKASVTFFQYCVLSNFYW 219

  Fly   214 MLVEGLYLYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTPEKYEINCPWMQ 278
            :|||||||..|:..||:.....|..|..:|||.|::.|..|...|     ||    |:....|..
Zfish   220 LLVEGLYLQTLLTFTFAHKRTFFWCYTLVGWGTPSVTVTIWTFLK-----YS----YDDYGCWDD 275

  Fly   279 -ETHVDWIYQGPVCAVLIINLTFLLRIMWVLI--TKLRSANTVETRQYRKAAKALLVLIPLFGIT 340
             ::...||.:.|:...:::|....:.|..::|  ||...:|..:.|.||:.||:.|:||||||:.
Zfish   276 LDSGFWWIIKIPILLSVLVNFLMFINISRIIIVKTKTPDSNGGDKRFYRRLAKSTLLLIPLFGVH 340

  Fly   341 YLVVLAGPSESGLMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEVRNALRHHISTWRDTRT 400
            |:|....|...||...:|..|  ||.|.|||.|:|.||||||||:|.:|..|..:: :||
Zfish   341 YIVFALFPEHVGLEARLFFEL--VLGSFQGFIVALLYCFLNSEVQNEIRKEIEKYK-SRT 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	17/61 (28%)
		7tmB1_DH_R	126..394	CDD:320391	105/276 (38%)
		TM helix 1	129..153	CDD:320391	10/23 (43%)
		TM helix 2	162..183	CDD:320391	9/23 (39%)
		TM helix 3	197..219	CDD:320391	10/21 (48%)
		TM helix 4	238..254	CDD:320391	6/15 (40%)
		TM helix 5	279..302	CDD:320391	4/22 (18%)
		TM helix 6	327..349	CDD:320391	11/21 (52%)
		TM helix 7	356..381	CDD:320391	13/24 (54%)
ghrhr2	NP_001106975.1	HRM	54..111	CDD:280888	18/63 (29%)
ghrhr2	NP_001106975.1	7tm_2	128..371	CDD:278432	92/256 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910