DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tfb1 and AT3G61420

DIOPT Version :9

Sequence 1:	NP_001246321.1	Gene:	Tfb1 / 36598	FlyBaseID:	FBgn0033929	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_191701.4	Gene:	AT3G61420 / 825315	AraportID:	AT3G61420	Length:	579	Species:	Arabidopsis thaliana

Alignment Length:	637	Identity:	156/637 - (24%)
Similarity:	276/637 - (43%)	Gaps:	143/637 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VRYK---KGDGT-----------LYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQ- 64
            |:||   |..||           |:|.|       :.:..:.:..:..:||:||.:.||..|..
plant     5 VKYKSFVKDPGTLGSLELSEVMLLFVPN-------DPKSDLKLKVQTHNIKSQKYTKEGSNKPPW 62

  Fly    65 LQVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDK-------------DLED 116
            |.:....|.:..|.|.|       ..|....::.:.:.|...:.:.:|             :.|.
plant    63 LNLTSKQGRSHIFEFEN-------YPDMHACRDFITKALAKCEEEPNKLVVLTPAEQLSMAEFEL 120

  Fly   117 KNRILVENPNLLQLYKDLVITKVLTSDEFWATHAK---DHALKKMGRSQEIGVSGAFLADIKPQT 178
            :.::|.||..|.:|:|..|.:||||.||||:|..|   ..:::|  ..|::|:....::.|||.|
plant   121 RFKLLRENSELQKLHKQFVESKVLTEDEFWSTRKKLLGKDSIRK--SKQQMGLKSMMVSGIKPST 183

  Fly   179 DG-CNGLKYNLTSDVIHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTA----- 237
            || .|.:.:||||::|..||...|||::.....||.||:|.:||||:|::.|.:..:.||
plant   184 DGRTNRVTFNLTSEIIFQIFAEKPAVRQAFINYVPKKMTEKDFWTKYFRAEYLYSTKNTAVAAAE 248

  Fly   238 GTKD----IFTECGKIDDQALKAAVQQGAGDPLLDLKKFEDVP----LEEGFGSVAGDRNVVNSG 294
            ..:|    :|.:..:|  .|.:|..:....||.||:...|...    ::.|. ...|..:::...
plant   249 AAEDEELAVFLKPDEI--LAQEARQKMRRVDPTLDMDADEGDDYTHLMDHGI-QRDGTNDIIEPQ 310

  Fly   295 N-IVHQNMIKRFNQHSIMVLK-TCANVTSAPS-------TMTNGTNNANGPVSQSAYTNGMNGKG 350
            | .:.:::::..|:|:.:||: .|.||.|..:       |.....:.|:|.:::.|....:....
plant   311 NDQLKRSLLQDLNRHAAVVLEGRCINVQSEDTRIVAEALTRAKQVSKADGEITKDANQERLERMS 375

  Fly   351 QATATATKSSSDQVDKDEPQS---KKQRLMEKIHYVD------LGDPILEGDDSANGEKAKSKHF 406
            :||        :..|...||:   ....:.:...|.:      |.:|        .|.||..::.
plant   376 RAT--------EMEDLQAPQNFPLAPLSIKDPRDYFESQQGNILSEP--------RGAKASKRNV 424

  Fly   407 ELSKVERYLNGPVQNSM----YDNHNDPMSLEEVQYKLVRNSESWLNRNVQRTFICSKAAVNALG 467
            .    |.|  |.::.|:    ....:||:...||.:::.    |.|.|.:       ..|.|.||
plant   425 H----EAY--GLLKESILVIRMTGLSDPLIKPEVSFEVF----SSLTRTI-------STAKNILG 472

  Fly   468 ELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEELETKLQRMHETL 532
            : :|        ||....:| |...:.|:.|.:.|:.||::||||.:|.|:..|.||:.::.:.:
plant   473 K-NP--------QESFLDRL-PKSTKDEVIHHWTSIQELVRHFWSSYPITTTYLSTKVGKLKDAM 527

  Fly   533 QRF-----KMAKLVPFENRAMHELS----PLRSSLT---QHLNQLLRTANSK 572
            ...     .|.:.|..:.|  |::|    |::.:|.   ||....|:...:|
plant   528 SNTYSLLDAMKQSVQSDLR--HQVSLLVRPMQQALDAAFQHYESDLQRRTAK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tfb1	NP_001246321.1	PH_TFIIH	10..104	CDD:270049	22/103 (21%)
		BSD	104..157	CDD:128990	19/68 (28%)
		BSD	181..234	CDD:281847	22/52 (42%)
AT3G61420	NP_191701.4	PH-like	6..95	CDD:302622	21/102 (21%)
		BSD	119..161	CDD:128990	18/41 (44%)
		BSD	188..238	CDD:128990	22/49 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	56	1.000	Domainoid score	I4061
eggNOG	1	0.900	-	-		E1_KOG2074
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3885
Inparanoid	1	1.050	127	1.000	Inparanoid score	I1914
OMA	1	1.010	-	-		QHG55753
OrthoDB	1	1.010	-	-		D946128at2759
OrthoFinder	1	1.000	-	-		FOG0004248
OrthoInspector	1	1.000	-	-		otm2984
orthoMCL	1	0.900	-	-		OOG6_103656
Panther	1	1.100	-	-	O	PTHR12856
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840