DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tfb1 and gtf2h1

DIOPT Version :9

Sequence 1:	NP_001246321.1	Gene:	Tfb1 / 36598	FlyBaseID:	FBgn0033929	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_012809948.1	Gene:	gtf2h1 / 448768	XenbaseID:	XB-GENE-975300	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	591	Identity:	270/591 - (45%)
Similarity:	374/591 - (63%)	Gaps:	58/591 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQL 65
            |.||||:|||.:.:||:||.||.||:|.|||||..|.:|..|:||.|||||.|||||:||.||||
Frog    10 MATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQL 74

  Fly    66 QVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQL 130
            |:|||.|.|:.|||.|   .|..:.:||.||||||||||.||||.:|:||:|||:|.|:|.|.||
Frog    75 QLVLHVGETTNFHFSN---DATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQL 136

  Fly   131 YKDLVITKVLTSDEFWATHAKDHALKK--MGRSQEIGVSGAFLADIKPQTDGCNGLKYNLTSDVI 193
            |||||:::|::::||||.....::|..  :...|::|:|.|||||::|||||||||:||||||:|
Frog   137 YKDLVVSQVISAEEFWANRLSLNSLDSSVLASKQDVGISAAFLADVRPQTDGCNGLRYNLTSDII 201

  Fly   194 HCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAV 258
            ..||:||||||.|:.||||..|:|.:||.:||||||||||||..|.||:|.||.|:|::.||:.|
Frog   202 ESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMV 266

  Fly   259 QQGAGDPLLDLKKFEDVPLEEGFG-----SVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCAN 318
            .||..:|:|||...||..||||:|     |.:..:::..:.|..   :|||||.||.|||.....
Frog   267 SQGVKNPMLDLMALEDKCLEEGYGISSAPSTSSTKSIKENSNAA---IIKRFNHHSAMVLAAGLR 328

  Fly   319 VTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIHYV 383
            ...|.|...:.|::.:|                        :|...|...|..||.:|.|.|.|.
Frog   329 KDEAQSDQCSETSSTDG------------------------NSRDSDFFLPPVKKVKLQEAIEYE 369

  Fly   384 DLGDPILEGDDSANGEKAKSKHFELSKVERYLNG--PVQNSMYDNHNDPM-SLEEVQYKLVRNSE 445
            ||        |.:||  .|.....|.|.:||.:|  |:|:..|.:..|.: |:..::.::    |
Frog   370 DL--------DQSNG--MKPLVLNLKKSDRYYHGPTPIQSQQYASSQDILSSIHSIKQQM----E 420

  Fly   446 SWLNRNVQRTFICSKAAVNALGELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHF 510
            ::..|..|  .:.|.||.:....|:|||::|:|..:|:..||||||.|.||:|||:::.|||:||
Frog   421 NYTPRLTQ--VLSSGAASSTTAALTPGGALMQGVTQQAINQLVPNDIQSELKHLYVAVGELLRHF 483

  Fly   511 WSCFPPTSEELETKLQRMHETLQRFKMAKLVPFENRAMHELSPLRSSLTQHLNQLLRTANSKFAT 575
            |||||..:..||.|:.:|...|:||::.||.||:.:...:.  |.::||.||.::|:||.:||.|
Frog   484 WSCFPVNTPFLEEKVMKMKSNLERFQVTKLRPFQEKLRKQY--LGTNLTGHLEEMLQTAYTKFHT 546

  Fly   576 WKERKL 581
            |:.|::
Frog   547 WQSRRM 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tfb1	NP_001246321.1	PH_TFIIH	10..104	CDD:270049	57/93 (61%)
		BSD	104..157	CDD:128990	28/52 (54%)
		BSD	181..234	CDD:281847	37/52 (71%)
gtf2h1	XP_012809948.1	PH_TFIIH	19..111	CDD:270049	58/94 (62%)
		BSD	110..163	CDD:128990	28/52 (54%)
		BSD	190..240	CDD:128990	34/49 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3053
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3885
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355210at33208
OrthoFinder	1	1.000	-	-		FOG0004248
OrthoInspector	1	1.000	-	-		oto103186
Panther	1	1.100	-	-	LDO	PTHR12856
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1500
SonicParanoid	1	1.000	-	-		X4051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190