DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arc2 and Arc

DIOPT Version :9

Sequence 1:	NP_610956.1	Gene:	Arc2 / 36597	FlyBaseID:	FBgn0033928	Length:	193	Species:	Drosophila melanogaster
Sequence 2:	NP_001263613.1	Gene:	Arc / 11838	MGIID:	88067	Length:	396	Species:	Mus musculus

Alignment Length:	184	Identity:	48/184 - (26%)
Similarity:	80/184 - (43%)	Gaps:	13/184 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EQFRIFIETIKSLGPIKEEPPSKGSFSNCTVRFSGQRDHDAVDEFINAVETYKEVEGISDKDALK 71
            ||..:..:..:|.||.::..||.|.   .|..|...|      ||::.:|.|....|.|::..|.
Mouse   185 EQESVEAQQYQSWGPGEDGQPSPGV---DTQIFEDPR------EFLSHLEEYLRQVGGSEEYWLS 240

  Fly    72 GLPLLFKSIAVVWWKGVRRDAKTWSDALQLLRDHFSPTKPSYQIYMEIFETKQSYDEVIDSFICK 136
            .:.......|..||:..:...|.|.:..:....:...|.....|..|: |..|...|.:|.|:.:
Mouse   241 QIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQREL-ELPQKQGEPLDQFLWR 304

  Fly   137 QRALLAKLPEGRHDEETELDFIYGLMQPKYRESIPRHEV-KTFRELLDRGRTVE 189
            :|.|...|.....:||. :.::.|.:|||.:..: ||.: ||..:|:.||..|:
Mouse   305 KRDLYQTLYVDAEEEEI-IQYVVGTLQPKLKRFL-RHPLPKTLEQLIQRGMEVQ 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arc2	NP_610956.1	None
Arc	NP_001263613.1	Interaction with SH3GL1 or SH3GL3. /evidence=ECO:0000250\|UniProtKB:Q63053	89..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..207		6/21 (29%)
		Interaction with DNM2. /evidence=ECO:0000250\|UniProtKB:Q63053	195..214		7/21 (33%)
		Arc_C	278..360	CDD:375599	25/82 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..396		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910