DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arc1 and Arc

DIOPT Version :9

Sequence 1:	NP_610955.1	Gene:	Arc1 / 36595	FlyBaseID:	FBgn0033926	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_062234.2	Gene:	Arc / 54323	RGDID:	62037	Length:	396	Species:	Rattus norvegicus

Alignment Length:	216	Identity:	50/216 - (23%)
Similarity:	80/216 - (37%)	Gaps:	23/216 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AVGAAGSAAAAGGADASRGKGNFSACTHSFGGTRDHDVVEEFIGNIETYKDVEGISDENALKGIS 87
            :|||....:...|.|.....|   ..|..|...|      ||:.::|.|....|.|:|..|..|.
  Rat   188 SVGAQQYQSWVPGEDGQPSPG---VDTQIFEDPR------EFLSHLEEYLRQVGGSEEYWLSQIQ 243

  Fly    88 LLFYGMASTWWQGVRKEATTWKEAIALIREHFSPTKPAYQIYMEFFQNKQDDHDPIDTFVIQKRA 152
            ....|.|..||:..:.....|.|......::...|.....|..| ....|...:|:|.|:.:||.
  Rat   244 NHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRE-LDLPQKQGEPLDQFLWRKRD 307

  Fly   153 LLAQLPSGRHDEETELDLLFGLLNIKYRKHISRHSVHTFKDLLEQGRIIEHNNQ----------- 206
            |...|.....:||. :..:.|.|..|:::.:......|.:.|:::|..::...:
  Rat   308 LYQTLYVDAEEEEI-IQYVVGTLQPKFKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLP 371

  Fly   207 -EDEEQLATAKNTRGSKRTTR 226
             |||.:..|...|..|..:.|
  Rat   372 TEDETEALTPALTSESVASDR 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arc1	NP_610955.1	None
Arc	NP_062234.2	Interaction with SH3GL1 or SH3GL3. /evidence=ECO:0000269\|PubMed:17088211	89..100
		Interaction with DNM2. /evidence=ECO:0000269\|PubMed:17088211	195..214		4/21 (19%)
		Arc_C	278..360	CDD:407993	19/83 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..396		7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910