DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arc1 and Arc

DIOPT Version :9

Sequence 1:	NP_610955.1	Gene:	Arc1 / 36595	FlyBaseID:	FBgn0033926	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001263613.1	Gene:	Arc / 11838	MGIID:	88067	Length:	396	Species:	Mus musculus

Alignment Length:	212	Identity:	49/212 - (23%)
Similarity:	82/212 - (38%)	Gaps:	35/212 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RELIEAVRAAAVGAAGSAAAAGGADASRGKGNFSACTHSFGGTRDHDVVEEFIGNIETYKDVEGI 77
            :|.:||.:..:.|.......:.|.|           |..|...|      ||:.::|.|....|.
Mouse   186 QESVEAQQYQSWGPGEDGQPSPGVD-----------TQIFEDPR------EFLSHLEEYLRQVGG 233

  Fly    78 SDENALKGISLLFYGMASTWWQGVRKEATTWKEAIALIREHF------SPTKPAYQIYMEFFQNK 136
            |:|..|..|.....|.|..||:..:.....|.|    .::.|      :.::.|.|..:|.   .
Mouse   234 SEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVE----FKKEFLQYSEGTLSREAIQRELEL---P 291

  Fly   137 QDDHDPIDTFVIQKRALLAQLPSGRHDEETELDLLFGLLNIKYRKHISRHSVHTFKDLLEQGRII 201
            |...:|:|.|:.:||.|...|.....:||. :..:.|.|..|.::.:......|.:.|:::|..:
Mouse   292 QKQGEPLDQFLWRKRDLYQTLYVDAEEEEI-IQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEV 355

  Fly   202 EHNNQEDEEQLATAKNT 218
                |:..||.|....|
Mouse   356 ----QDGLEQAAEPSGT 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arc1	NP_610955.1	None
Arc	NP_001263613.1	Interaction with SH3GL1 or SH3GL3. /evidence=ECO:0000250\|UniProtKB:Q63053	89..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..207		4/20 (20%)
		Interaction with DNM2. /evidence=ECO:0000250\|UniProtKB:Q63053	195..214		4/29 (14%)
		Arc_C	278..360	CDD:375599	20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..396		5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910