Protein Alignment Shrm and shroom4

DIOPT Version :10

• Sequence 1: NP_001097307.1
• Gene: Shrm / 36592
• FlyBaseID: FBgn0085408
• Length: 1576
• Species: Drosophila melanogaster
• Sequence 2: NP_001072744.1
• Gene: shroom4 / 780201
• XenbaseID: XB-GENE-5949019
• Length: 1721
• Species: Xenopus tropicalis
• Alignment Length: 1840
• Identity: 374/1840 - (20%)
• Similarity: 605/1840 - (32%)
• Gaps: 569/1840 - (30%)

  Fly    59 SFSSASVAGSVQDDLP-------HHNSS--SSQLGQQHGSSLDQCGLTQAGLEEYNNRSSSYYDQ 114
            :||.:..:|....:||       .|.|:  ||.:|..  .||||.|             .:||:.
 Frog   124 AFSLSWHSGCENSELPMQWNPLSRHCSTDKSSSIGSM--ESLDQPG-------------HNYYEG 173

  Fly   115 TAFHHQKQPSYAQSEGYHSYVSSSDSTSATPF-----------LD-------------------- 148
            |.  ....||..|::...:|.|.|.|::|:.:           :|
 Frog   174 TL--SPIDPSMYQNKRDSAYSSFSASSNASDYTLSARAEESSQMDCVADSSKPCDGRYLHTGQGA 236

  Fly   149 -KLRQESDLLSRQSHH-------WSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAHSHSNSHG 205
             :::||:..||...|.       :..|.||.:.|     .|.|.:.|.|...|.:..
 Frog   237 IEIQQETSSLSPSEHQQRPSSFPFDANHLSFIKS-----PPQPPIRRDSLRASKNQI-------- 288

  Fly   206 HSHGHAHSASSSSSSNNNSNGSATNNNNNNSSESTS----------------STETLKWLGSMSD 254
             .||....||:...|...|...::.|..:.:|:::.                |::....|.|.:|
 Frog   289 -CHGERRRASAPGDSLQISGMWSSENQQHKNSDTSQCKCGIEFCTVHLKNGLSSDQYYMLSSQTD 352

  Fly   255 ISEASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQMMIS 319
              ..:.:|...|:|:....|......||.|...|:..:::     |:|..:||   .:|:|.:.:
 Frog   353 --GGNQSTDQLALSDREMPSCCTEMQSRWPRDGRNIKQTI-----NKEMENSS---YHSAQTVKT 407

  Fly   320 EEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTN-------QS 377
            .:.:..:.|..:      |..|.|.|              |.:|::....::.|..       |.
 Frog   408 VKDSLSKHPSCL------HMKSSSLP--------------QSEQEEVSVQTKFHRKEWRNTLLQE 452

  Fly   378 TLSTQSSLLELASPTEKPRSLMGQSH--------SMGDLQQ---KNPHQNPMLGRSAGQQHKSSI 431
            ....|:|.....|..|...::...|.        ..||..|   ||..|:         ||.:::
 Frog   453 NFQCQTSECNGISSQELKCNINRDSEIYQVDTLTDTGDFSQLSGKNKEQS---------QHITTL 508

  Fly   432 SVTISS----SEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQS--------PTNSIDS 484
            ..::|.    .|:...:.|:...|           ....|||:..:.|:|        ||....|
 Frog   509 ERSVSEPNEVRESFPVLLPKHSVG-----------GMRSSCSSETLLEESHEQEESQGPTKKPGS 562

  Fly   485 YRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAERIND 549
              |.||...:...::...:|....:|..|.|.......|..|....|.....:||
 Frog   563 --SRHRSAQMRRRSDRFATNLRNEIQRRKAQLQKNKGSSVLLCGEEPVEEREEPT---------- 615

  Fly   550 FERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLL----------- 603
              .||  .||:  .:.|....:..:..|:..:.||.|.:.....|..::.:|.|
 Frog   616 --ESQ--SPPR--PMPPPPPPKNKSRLLELKRANAEQFHKGTDHQHLEQNKQSLPSNRDTDKDNQ 674

  Fly   604 RPHSQSYQACHVERKSLPNNLSPIMVG-LPTGSNSASTRDCSSPTPPPPPRRSGSLLPNLLRRSS 667
            :....|..|  ||..:..|:.|.|... |...||.:...|        |.::....:.:.|...|
 Frog   675 KTEENSLNA--VENVTRANDKSLISKSRLQNESNKSFVYD--------PRQKDHQRVSSELNNES 729

  Fly   668 ---SASDYAE--------FRELHQAQGQVKGPSIRNI--SNAEKISFNDCGMPPPPPPP------ 713
               ||.:..|        |:..|....:.:.|.:.|:  |:|..:.:|:.....|.|..
 Frog   730 TMPSAENCREEWRTREPDFQRQHSKCLEQREPELGNVAESSATTVRWNEVSRASPNPDVKVSHEM 794

  Fly   714 -RGRLAVPTRRTSSATE-----------------------------------YA----------- 731
             |...::......|.||                                   |:
 Frog   795 WRASSSLSINSVGSQTENFRGIGVESHSHYSGHKSLDADASFNGLLSSKEQLYSDGSSNDDWRIS 859

  Fly   732 ------PM---RDKLLLQQAAALAHQQHHPQQ--HRHA----QPPHVPPERPPKHPNLRVP---- 777
                  ||   |:.:..:...:..|......|  .||:    :.|||.          ::|
 Frog   860 CLDNEEPMQRGREMMFSEPGRSSDHTSLFAAQWRSRHSSSDFEDPHVQ----------QMPNGGR 914

  Fly   778 ---SPE---LPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNR----RNCFAGASTRRTTY 832
               |||   ||.|..|:           ..||...|:.......|||    .|.....:.||..:
 Frog   915 WKWSPEHKLLPHPQLSK-----------GSPPDVSVVHAEGASLPNRVASEENVLMPFADRRRFF 968

  Fly   833 EAPPPTAIVAAKVPPL--VPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLL 895
            |.       ::|||.:  :|     ||.|        |.|            |...|..|.|||.
 Frog   969 EN-------SSKVPNVSHIP-----LQIK--------SNK------------NNYCPSFPDPPLS 1001

  Fly   896 PRARSTAHDNVIASNLESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVA---H 957
            .:..|....:.:......:...|.:|...|         ::...:|.:..|...|.....|   |
 Frog  1002 QKVVSALRRHSVDHTYHPSSPNRQDSALPY---------SDYCVNHTVDPLLCCSQGGHAAEYIH 1057

  Fly   958 TKPSYG--VTGKLPNNLPDVLPLGVK------------LHQQPKLQPGSPNGD-----ANVTLRY 1003
            ....||  |.........||.|..||            ||........|..||     .:.||..
 Frog  1058 HPTGYGCRVHESCHCCSSDVCPALVKRNMPMSHLSCHFLHHHHHHHQWSRCGDYLCPAQHSTLEE 1122

  Fly  1004 GSNNNLTGN-----SPTVAPPPYYGGGQRYSTP------------VLGQGYGK---------SSK 1042
            |:  :|.|:     .|.:...|.....|:...|            ....|:.:         :|:
 Frog  1123 GT--SLHGDPWHLQKPVLQEVPLKEWTQQLKIPNRKCSQSGSDLCHSNSGFHRAGPFRPCCDNSE 1185

  Fly  1043 PVTPQQYTRSQSYDVKHTSAVTMPTMSQSH--------------------VDLKQAAHDLETT-- 1085
            ...||.|....|||:....:: .|.:|..|                    :|........||:
 Frog  1186 QDFPQCYRTVSSYDLSCEHSI-RPELSSHHDEPSDQNLGRGRAYSVSQLNLDCLALRDKKETSLS 1249

  Fly  1086 -LEEVLPTATPTPTPTPTPTPPRL--------------SPASSHSDCSLSTS---SLECTINPIA 1132
             |||.:|:|.......|.|.||..              |..|.|.:.|:.:.   |:| .:...:
 Frog  1250 KLEEHMPSALAKKQKPPRPPPPNWDKYKERRASHQLTNSILSRHRENSVGSGHSISME-AVRQRS 1313

  Fly  1133 TPIPKPEAHIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLG 1197
            ..:|....      ::....|.:|.:....|          .|...:.:.|.|..||
 Frog  1314 QSLPMERI------LLKANENYHPSSECEHP----------QIRDCSPVPSDLRPAH-------- 1354

  Fly  1198 GYTTPLITSPTASFA-----NEPL---MTPPLPPSPP-----PPLEPEEEEEQEENDVHD--KQP 1247
              ..|..::.|.|..     .||.   ...|...|||     .|.:|......:..|.:.  :..
 Frog  1355 --QEPDTSADTVSTTFEHARQEPFSDCRNSPRDASPPRTDHLVPSDPVTSSHHQTTDFYSPLEGG 1417

  Fly  1248 EIEELQLMQRSELVLMVNPKPSTTDMACQTDELEDRDTDLEAAREEHQTRTTLQPRQRQPIEL-- 1310
            .|||                ||.:    ..:|.||   .:...:..|...:...|.:..|..|
 Frog  1418 SIEE----------------PSNS----VAEESED---GVIPPKSTHDHISPDIPEREHPANLLD 1459

  Fly  1311 -------DYE---QMSRELVKLLPPGDKIADILTPKIC---KPTSQYVSNLYNPDVPLRLAKRDV 1362
                   .||   ...||....:|...:...|..|.:|   .|||  .:..||...    ||.::
 Frog  1460 GFDSGYRHYEDEWSTDRESEISIPERYEFQPISPPPVCGAVSPTS--CAAYYNTSA----AKAEL 1518

  Fly  1363 GTSTLMRMKSITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEE 1427
                |.:||.:....|      |:...|..||...|..:|: :||:.:::|:..|...||.:.|:
 Frog  1519 ----LNKMKELPGLQE------EVGDQEEVEEEDELSLKKV-QLIESISRKVSVLHEAQQGLQED 1572

  Fly  1428 CSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQQERGA- 1491
            .:||..||.::...|....:|:|..||||.:..:..:.:||||||.|||:.||.|.:...|...
 Frog  1573 INANTTLGCEMADLLKNLCKPNEYEKFRTFIGDLEKVVNLLLSLSGRLARVESVLSSEDPEPSVD 1637

  Fly  1492 -----LESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADAR 1551
                 ||.|:.|. ||:|:|:.|::.:.||...:...:::.|:.:...||.:::.|.:.||.:.|
 Frog  1638 EKLNLLEKKKQLT-EQLEDAKELRAHVTRREHMVLESVSRYLNEEQLQDYHHYVKMTSALIVEQR 1701

  Fly  1552 DLAVRIKGSEEQLSSLSDAL 1571
            :|..:|:..||||..|.::|
 Frog  1702 ELEDKIRLGEEQLRCLRESL 1721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1571	CDD:462561	78/261 (30%)
shroom4	NP_001072744.1	PDZ_shroom2_3_4-like	11..92	CDD:467232
		ASD2	1438..1721	CDD:462561	85/300 (28%)