|
Fly 14 EMGESTKSLAKMEP------ENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSSASVAGSVQDD 72
:.||..:|....|| |::| .::.:.|.::..| .|.|.|...:.|:.|...::.:.
Human 612 QAGEDKRSSRLSEPWEGDFQEDHN----ANLWRRLEREGLG-QSLSGNFGKTKSAFSSLQNIPES 671
Fly 73 LPHHNSSSSQLGQQHG--SSLDQCGL-TQAGLEEYNNRSSSYYDQTAFHHQKQPSYAQSEGYHSY 134
|..|:|.....|.|.| .....|.: |:| |:...::: .....|..:|.||.:.||....
Human 672 LRRHSSLELGRGTQEGYPGGRPTCAVNTKA--EDPGRKAA---PDLGSHLDRQVSYPRPEGRTGA 731
Fly 135 VSSSDSTSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAH- 198
.:|.:||..:| ...|:| ||.|:.|...
Human 732 SASFNSTDPSP------------------------------EEPPAP-------SHPHTSSLGRR 759
Fly 199 -----SHSNSHGHSHGHAHSA----------SSSSSSNNNSNGSATNNN-NNNSSESTSSTETLK 247
|.|...|..:|..|.: ....|...:..||...:| ..:.:.|||||
Human 760 GPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSST---- 820
Fly 248 WLGSMSDISEASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASN 312
|.:|..|......:|..:|.:.:.: :|.....|.| |:....|....
Human 821 ---SGNDFEETKAHIRFSESAEPLGNGE------------QHFKNGELKL----EEASRQPCGQQ 866
Fly 313 SSQMMISEEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQS 377
.|. ..|:...|.:. |..:.||.|.. ||...:.:::.:...|..:.:|
Human 867 LSG-GASDSGRGPQR-PDARLLRSQST----------------FQLSSEPEREPEWRDRPGSPES 913
Fly 378 TL-------STQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTI 435
.| :.::|:.:..| |.|...|....||:...| :...:.:...||..|.:
Human 914 PLLDAPFSRAYRNSIKDAQS-----RVLGATSFRRRDLELGAP-----VASRSWRPRPSSAHVGL 968
Fly 436 SSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQS-PTNSIDSYRSNHRLFPVS---T 496
.|.||..:.:|..|..:.| .||..|:.: |........:..||.|.. :
Human 969 RSPEASASASPHTPRERHS--------------VTPAEGDLARPVPPAARRGARRRLTPEQKKRS 1019
Fly 497 YTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKF 561
|:||...|....|:..:|..........:.|. .|||:|...|||..
Human 1020 YSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPE------------SSVADRRRLFERDG------- 1065
Fly 562 AYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQK--------EEQQLLRPHSQSYQACHVERK 618
:...|..||.|.||..|::|:..|::|:..::. :|...||..:||..
Human 1066 ---KACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAY------- 1120
Fly 619 SLPNNLSPIMVGLPTGSNSASTRDCSSPTPPP-PPRRSGSLLPNLLRRSSSA-----SDYAEFRE 677
|.|....| .||..||....||...|. .|||..:|||..:..:..| |.:|..|.
Human 1121 -----LQPGPAAL-EGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRR 1179
Fly 678 LHQ---------AQGQVKG----------PSI------RNISNAEKISFNDCGMPPPPPPPRGRL 717
|.: |.|..:| ||. :::|..:.:..:|. |
Human 1180 LGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLERSDV------------L 1232
Fly 718 AVPTR---RTSSATEYAPMRDKLLLQQAAAL----------------------AHQQHHPQQHRH 757
|.|.. |:|.|| |..|..:||.|.:.. ..::..|..| |
Human 1233 AGPVHVRSRSSPAT--ADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFH-H 1294
Fly 758 AQP------------PHVPPERP----PKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPE 806
..| ..||.|.| .:....|.|.|. ||...::..::.|...||.|
Human 1295 LTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPR-PPLAGTQGLVTDTRAAPLTP----- 1353
Fly 807 VLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANG------- 864
:..|.|...|: ..|.....|.| .||.|..|..: |.:||
Human 1354 IGTPLPSAIPS-GYCSQDGQTGR----------------QPLPPYTPAMM---HRSNGHTLTQPP 1398
Fly 865 ------GGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNSKA 923
|.| |.|...:...:.|:.|..|||.....|.:...|::.. ||:....:|.|
Human 1399 GPRGCEGDG----PEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPE---ESSAPDFANLK- 1455
Fly 924 SYLPRQSLEKLNNT-DPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVKLHQQPK 987
.|..:|||..|.:| ||| .||
Human 1456 HYQKQQSLPSLCSTSDPD-----------------------------------TPL--------- 1476
Fly 988 LQPGSPNGDANVTLRYGSNNNLTGNSPTV---APPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQY 1049
|:|:....::||. |.:| :|||: :.|...| :
Human 1477 ---GAPSTPGRISLRI---------SESVLRDSPPPH----EDYEDEV----------------F 1509
Fly 1050 TRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPTATPTPTPTPTPTPPRLS----- 1109
.|. .|..|.:.||. |.|| |.|.|.|:...|..|
Human 1510 VRD-----PHPKATSSPTF-------------------EPLP---PPPPPPPSQETPVYSMDDFP 1547
Fly 1110 PASSHSDCSLSTSSLECTINPIATPIPKPE------------------AHIFRAEVISTTLNTN- 1155
|...|:.|.....|.: |.. |:|. ||:..::.:::.|.|:
Human 1548 PPPPHTVCEAQLDSED----PEG---PRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSI 1605
Fly 1156 ----PLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPL 1216
..:|||. .||.|...|..|||...|: .|.|.:::|:
Human 1606 KGSEAESTPPS----------------------FMSVHAQLAGSLGGQPAPI---QTQSLSHDPV 1645
Fly 1217 MTPPLPPSPPPPLEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTDELE 1281
|....||.: |:|.|..:. |
Human 1646 -------SGTQGLEKK-------------------------------VSPDPQKSS--------E 1664
Fly 1282 DRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELVKLLPPGDKIADILTP-KICKPTSQYV 1345
|..|:..|....||.:: :||||.| ...|.|...:
Human 1665 DIRTEALAKEIVHQDKS------------------------------LADILDPDSRLKTTMDLM 1699
Fly 1346 SNLYNPDVPLRLAKRDVGTSTLMRMKSITSSA-------EIRVVSVEL------QLAEPSEEPTN 1397
..|:..||.| |.:..|....:.| :::||. :...||:.: .::.|..|..|
Human 1700 EGLFPRDVNL-LKENSVKRKAIQR--TVSSSGCEGKRNEDKEAVSMLVNCPAYYSVSAPKAELLN 1761
Fly 1398 LIK----------------QKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKV 1446
.|| :|..|||..|..|:.:|:..:.::..:...|:.||:::.|.::|..
Human 1762 KIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELC 1826
Fly 1447 RPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQERGALESKRDLLYEQMEEA 1506
:|:|..|:|..:..:..:.:||||||.|||:.|:.| :...:||.:|..||.:|..|.|:|
Human 1827 KPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDA 1891
Fly 1507 QRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 1571
:.||.:::||...:.|:||..||.:...||.:|:.||:.|:.:.|.|..:||..:||:..|.::|
Human 1892 RELKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESL 1956
Fly 1572 1571
Human 1957 1956
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