Protein Alignment Shrm and SHROOM4

DIOPT Version :9

• Sequence 1: NP_001097307.1
• Gene: Shrm / 36592
• FlyBaseID: FBgn0085408
• Length: 1576
• Species: Drosophila melanogaster
• Sequence 2: XP_016885171.1
• Gene: SHROOM4 / 57477
• HGNCID: 29215
• Length: 1531
• Species: Homo sapiens
• Alignment Length: 1633
• Identity: 347/1633 - (21%)
• Similarity: 536/1633 - (32%)
• Gaps: 558/1633 - (34%)

  Fly   242 STETLKWLGSMSDISEASHATGYS---AISESVSSSQR-IVHSSRVPTPKRHHSESVLYLHNNEE 302
            |||....:|||..:.:...||..|   .|.:::..:|| ..:||.  :...:.|:..|.|...|.
Human   149 STEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDSAYSSF--SASSNASDCALSLRPEEP 211

  Fly   303 -------QGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHRH-SPSYPPVHTSMVLHHFQQQ 359
                   || ..||.:.|.:..::|.:.|..        |....| :||            .|..
Human   212 ASTDCIMQG-PGPTKAPSGRPNVAETSGGSR--------RTNGGHLTPS------------SQMS 255

  Fly   360 QQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSA- 423
            .:.|:.||                     :.|.:..|               .|.|.|:...|.
Human   256 SRPQEGYQ---------------------SGPAKAVR---------------GPPQPPVRRDSLQ 284

  Fly   424 --------GQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTN 480
                    |:|.::|..|.....:..:::.|..||..|::.....|..:..|....|.....|..
Human   285 ASRAQLLNGEQRRASEPVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPE 349

  Fly   481 SIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAE 545
            | ....|.|.|...||                         |:...|......::|..  :.:.|
Human   350 S-SQQGSEHLLMQAST-------------------------KAVGSPKACDRASSVDS--NPLNE 386

  Fly   546 RINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLLRPHSQSY 610
            ...:..::..|.||..  :.|| .||.|.|                        :|||..|.|
Human   387 ASAELAKASFGRPPHL--IGPT-GHRHSAP------------------------EQLLASHLQ-- 422

  Fly   611 QACHVE---RKSLPNNLSPIMVG-------------------LPTG------SNSASTRDC---- 643
               ||.   |.|....|.|:..|                   .|||      |....||..
Human   423 ---HVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRS 484

  Fly   644 -----SSPTPPP------PPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAE 697
                 .|.:.||      .|...|.|.||  |.|.:||:.|  .:...|.|.:...:....|..:
Human   485 LVLGHQSQSSPPHGEADGHPSEKGFLDPN--RTSRAASELA--NQQPSASGSLVQQATDCSSTTK 545

  Fly   698 KISFNDCGMPPPPPP-------------PRGRLAVPTRRTSS--ATEYAPMRDKLLLQQAAALAH 747
            ..|..:.|......|             .||| ::..||.|.  ||.   :|::  :|:..|...
Human   546 AASGTEAGEEGDSEPKECSRMGGRRSGGTRGR-SIQNRRKSERFATN---LRNE--IQRRKAQLQ 604

  Fly   748 QQHHP-QQHRHAQPPHVPPERPPKHPNLRVPSPEL------PPPPQSELDISYTFDEPLP-PPPP 804
            :...| .|....:.|....:.||:.|.|...:..|      ||.|:.:|     |::.:. ....
Human   605 KSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKL-----FNKSMMLRARS 664

  Fly   805 PEVLQPRPPP-----------SPNRRNCFAGAST--RRTTYEAPPPTAIVAAKVPPLVPKKPTSL 856
            .|.|...|..           ||.:|   .|.|:  ..|.::||.|::....|.
Human   665 SECLSQAPESHESRTGLEGRISPGQR---PGQSSLGLNTWWKAPDPSSSDPEKA----------- 715

  Fly   857 QHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDN--VIASNLESNQQKRS 919
             |.|....||..|..|.| ..||:   ||:.:..|        |...||  :.||..::.:.
Human   716 -HAHCGVRGGHWRWSPEH-NSQPL---VAAAMEGP--------SNPGDNKELKASTAQAGED--- 764

  Fly   920 NSKASYLP----RQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGV 980
               |..||    |:..|:.:.:.....:..||..||:......||       :..|...:.....
Human   765 ---AILLPFADRRKFFEESSKSLSTSHLPGLTTHSNKTFTQRPKP-------IDQNFQPMSSSCR 819

  Fly   981 KLHQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRY--------STPVLGQGY 1037
            :|.:.|..|            .|.|           |..||:...|.|        .||...:.:
Human   820 ELRRHPMDQ------------SYHS-----------ADQPYHATDQSYHSMSPLQSETPTYSECF 861

  Fly  1038 GKSS-------KPV--TPQQYTRSQSYDVKHTSAVT--------------------MPTM----- 1068
            ....       ||:  ....|.|:.||......|:.                    ||..
Human   862 ASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEICPALLKRNMMPNCYNCRC 926

  Fly  1069 -------------SQSHVDLKQAA-------HDLETTLEE----------------------VLP 1091
                         :..|..|:.::       ...:.|::|                      :.|
Human   927 HHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFPGDKWNPITGNRKTSQSGSEALKP 991

  Fly  1092 TATP-----TPTPTPTPTPP---RLS--------PASSHSDCSLSTSSLECTINPIATPIPKPEA 1140
            :.||     |.|...||..|   |||        .|.|.:..|.:|....|..|| |..:....|
Human   992 SWTPEDECSTSTFCCTPGVPASLRLSLRDRQGREMAHSKTSFSWATPFHPCLENP-ALDLSSYRA 1055

  Fly  1141 -----------H-IFRAEVISTTLNTNPLTTPPKPAMNRQ-----------------ESLRENIE 1176
                       | :.::|..|.....:.|.:.|.|..:|.                 :..||...
Human  1056 ISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFS 1120

  Fly  1177 KITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPPLPPSPPPP------------- 1228
            |..:.||.|:.|.                  ..:|.         ||.||||
Human  1121 KGDETQSDLLGAR------------------KKAFP---------PPRPPPPNWEKYRLFRAAQQ 1158

  Fly  1229 -----------LEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTDELED 1282
                       .|.|||||:||.:..:::.|.||    :..||........::...|...:|:.:
Human  1159 QKQQQQQQKQQEEEEEEEEEEEEEEEEEEEEAEE----EEEELPPQYFSSETSGSCALNPEEVLE 1219

  Fly  1283 RDT-----DLEAAREEHQT-------------------RTTL--QPRQRQPI------------- 1308
            :..     .||.:|:..|:                   |..|  ||.|.||.
Human  1220 QPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSG 1284

  Fly  1309 ELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQYVSNLYNPDVPLRLAKRDVGTSTLMRMKSI 1373
            :...|...:|.....||..      .|.|  |||  .|..||    :.:||.::    |.::|..
Human  1285 QEATESAKQEFQHFSPPSG------APGI--PTS--YSAYYN----ISVAKAEL----LNKLKDQ 1331

  Fly  1374 TSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDL 1438
            ...|||       .|.|  ||..:.:.||..:||:.:::|:..|:..|:.:.|:.:||..||:::
Human  1332 PEMAEI-------GLGE--EEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEEV 1387

  Fly  1439 FAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLET----RQQERGALESKRDLL 1499
            .|.|....:.:|..|:...|..:..:.:||||||.|||:.|::|.:    ..||:..|..|:..|
Human  1388 EANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQL 1452

  Fly  1500 YEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQL 1564
            ..|:.:|:.||..::||...:.|::::.|..|...||.:|:.||:.||.:.|:|..:||..||||
Human  1453 TGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQL 1517

  Fly  1565 SSLSDALV 1572
            ..|.::|:
Human  1518 KCLRESLL 1525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	80/255 (31%)
SHROOM4	XP_016885171.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157083
Domainoid	1	1.000	110	1.000	Domainoid score	I6298
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41129
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.030