Protein Alignment Shrm and SHROOM4

DIOPT Version :10

• Sequence 1: NP_001097307.1
• Gene: Shrm / 36592
• FlyBaseID: FBgn0085408
• Length: 1576
• Species: Drosophila melanogaster
• Sequence 2: XP_054183410.1
• Gene: SHROOM4 / 57477
• HGNCID: 29215
• Length: 1536
• Species: Homo sapiens
• Alignment Length: 1634
• Identity: 346/1634 - (21%)
• Similarity: 536/1634 - (32%)
• Gaps: 555/1634 - (33%)

  Fly   242 STETLKWLGSMSDISEASHATGYS---AISESVSSSQR-IVHSSRVPTPKRHHSESVLYLHNNEE 302
            |||....:|||..:.:...||..|   .|.:::..:|| ..:||.  :...:.|:..|.|...|.
Human   149 STEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDSAYSSF--SASSNASDCALSLRPEEP 211

  Fly   303 -------QGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHRH-SPSYPPVHTSMVLHHFQQQ 359
                   || ..||.:.|.:..::|.:.|..        |....| :||            .|..
Human   212 ASTDCIMQG-PGPTKAPSGRPNVAETSGGSR--------RTNGGHLTPS------------SQMS 255

  Fly   360 QQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSA- 423
            .:.|:.||                     :.|.:..|               .|.|.|:...|.
Human   256 SRPQEGYQ---------------------SGPAKAVR---------------GPPQPPVRRDSLQ 284

  Fly   424 --------GQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTN 480
                    |:|.::|..|.....:..:::.|..||..|::.....|..:..|....|.....|..
Human   285 ASRAQLLNGEQRRASEPVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPE 349

  Fly   481 SIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAE 545
            | ....|.|.|...||                         |:...|......::|..  :.:.|
Human   350 S-SQQGSEHLLMQAST-------------------------KAVGSPKACDRASSVDS--NPLNE 386

  Fly   546 RINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLLRPHSQSY 610
            ...:..::..|.||..  :.|| .||.|.|                        :|||..|.|
Human   387 ASAELAKASFGRPPHL--IGPT-GHRHSAP------------------------EQLLASHLQ-- 422

  Fly   611 QACHVE---RKSLPNNLSPIMVG-------------------LPTG------SNSASTRDC---- 643
               ||.   |.|....|.|:..|                   .|||      |....||..
Human   423 ---HVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRS 484

  Fly   644 -----SSPTPPP------PPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAE 697
                 .|.:.||      .|...|.|.||  |.|.:||:.|  .:...|.|.:...:....|..:
Human   485 LVLGHQSQSSPPHGEADGHPSEKGFLDPN--RTSRAASELA--NQQPSASGSLVQQATDCSSTTK 545

  Fly   698 KISFNDCGMPPPPPP-------------PRGRLAVPTRRTSS--ATEYAPMRDKLLLQQAAALAH 747
            ..|..:.|......|             .||| ::..||.|.  ||.   :|::  :|:..|...
Human   546 AASGTEAGEEGDSEPKECSRMGGRRSGGTRGR-SIQNRRKSERFATN---LRNE--IQRRKAQLQ 604

  Fly   748 QQHHP-QQHRHAQPPHVPPERPPKHPNLRVPSPEL------PPPPQSELDISYTFDEPLP-PPPP 804
            :...| .|....:.|....:.||:.|.|...:..|      ||.|:.:|     |::.:. ....
Human   605 KSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKL-----FNKSMMLRARS 664

  Fly   805 PEVLQPRPPP-----------SPNRRNCFAGAST--RRTTYEAPPPTAIVAAKVPPLVPKKPTSL 856
            .|.|...|..           ||.:|   .|.|:  ..|.::||.|::....|.
Human   665 SECLSQAPESHESRTGLEGRISPGQR---PGQSSLGLNTWWKAPDPSSSDPEKA----------- 715

  Fly   857 QHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDN--VIASNLESNQQKRS 919
             |.|....||..|..|.| ..||:   ||:.:..|        |...||  :.||..::.:.
Human   716 -HAHCGVRGGHWRWSPEH-NSQPL---VAAAMEGP--------SNPGDNKELKASTAQAGED--- 764

  Fly   920 NSKASYLP----RQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGV 980
               |..||    |:..|:.:.:.....:..||..||:......||       :..|...:.....
Human   765 ---AILLPFADRRKFFEESSKSLSTSHLPGLTTHSNKTFTQRPKP-------IDQNFQPMSSSCR 819

  Fly   981 KLHQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRY--------STPVLGQGY 1037
            :|.:.|..|            .|.|           |..||:...|.|        .||...:.:
Human   820 ELRRHPMDQ------------SYHS-----------ADQPYHATDQSYHSMSPLQSETPTYSECF 861

  Fly  1038 GKSS-------KPV--TPQQYTRSQSYDVKHTSAVT--------------------MPTM----- 1068
            ....       ||:  ....|.|:.||......|:.                    ||..
Human   862 ASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEICPALLKRNMMPNCYNCRC 926

  Fly  1069 -------------SQSHVDLKQAA-------HDLETTLEE----------------------VLP 1091
                         :..|..|:.::       ...:.|::|                      :.|
Human   927 HHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFPGDKWNPITGNRKTSQSGSEALKP 991

  Fly  1092 TATP-----TPTPTPTPTPP---RLS--------PASSHSDCSLSTSSLECTINPIATPIPKPEA 1140
            :.||     |.|...||..|   |||        .|.|.:..|.:|....|..|| |..:....|
Human   992 SWTPEDECSTSTFCCTPGVPASLRLSLRDRQGREMAHSKTSFSWATPFHPCLENP-ALDLSSYRA 1055

  Fly  1141 -----------H-IFRAEVISTTLNTNPLTTPPKPAMNRQ-----------------ESLRENIE 1176
                       | :.::|..|.....:.|.:.|.|..:|.                 :..||...
Human  1056 ISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFS 1120

  Fly  1177 KITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPPLPPSPPPP------------- 1228
            |..:.||.|:.|.                  ..:|.         ||.||||
Human  1121 KGDETQSDLLGAR------------------KKAFP---------PPRPPPPNWEKYRLFRAAQQ 1158

  Fly  1229 ------------LEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTDELE 1281
                        .:.|||||:||.:..:::.|.||....:..||........::...|...:|:.
Human  1159 QKQQQQQQQQQQKQQEEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVL 1223

  Fly  1282 DRDT-----DLEAAREEHQT-------------------RTTL--QPRQRQPI------------ 1308
            ::..     .||.:|:..|:                   |..|  ||.|.||.
Human  1224 EQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTS 1288

  Fly  1309 -ELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQYVSNLYNPDVPLRLAKRDVGTSTLMRMKS 1372
             :...|...:|.....||..      .|.|  |||  .|..||    :.:||.::    |.::|.
Human  1289 GQEATESAKQEFQHFSPPSG------APGI--PTS--YSAYYN----ISVAKAEL----LNKLKD 1335

  Fly  1373 ITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQD 1437
            ....|||       .|.|  ||..:.:.||..:||:.:::|:..|:..|:.:.|:.:||..||::
Human  1336 QPEMAEI-------GLGE--EEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEE 1391

  Fly  1438 LFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLET----RQQERGALESKRDL 1498
            :.|.|....:.:|..|:...|..:..:.:||||||.|||:.|::|.:    ..||:..|..|:..
Human  1392 VEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQ 1456

  Fly  1499 LYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQ 1563
            |..|:.:|:.||..::||...:.|::::.|..|...||.:|:.||:.||.:.|:|..:||..|||
Human  1457 LTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQ 1521

  Fly  1564 LSSLSDALV 1572
            |..|.::|:
Human  1522 LKCLRESLL 1530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1571	CDD:462561	80/256 (31%)
SHROOM4	XP_054183410.1	PDZ_shroom2_3_4-like	9..90	CDD:467232
		ASD2	1286..1529	CDD:462561	81/269 (30%)