DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shrm and shroom4

DIOPT Version :9

Sequence 1:	NP_001097307.1	Gene:	Shrm / 36592	FlyBaseID:	FBgn0085408	Length:	1576	Species:	Drosophila melanogaster
Sequence 2:	XP_005172390.1	Gene:	shroom4 / 559035	ZFINID:	ZDB-GENE-041111-246	Length:	1634	Species:	Danio rerio

Alignment Length:	1814	Identity:	352/1814 - (19%)
Similarity:	589/1814 - (32%)	Gaps:	584/1814 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GNGSEMG------------ESTKSLAKMEPENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSS 62
            |:.||:.            :.:.|:..||...|........|:|...|....|::..::.:|||:
Zfish   142 GDNSELSMQWGHISRHYSTDRSSSIGSMESLENPPNQGYYDSQLSPIDPVIFNNKRDSAYSSFSA 206

  Fly    63 ASVAGSVQDDL-PHHNSSSSQLGQQHGSSLDQCGLTQAGLEE----YNNRSSSYYDQTAFHHQKQ 122
            :|........: |...:|...|.|..|||   |.....|...    :.|:............:.:
Zfish   207 SSNTSDYTVPVKPEETNSMDSLLQGLGSS---CRYPDRGQHSAPTGHGNQLEEQEHSKVLSGRSE 268

  Fly   123 PSYAQSEGYHSYVSSSDSTSATPFLDKLRQESDLLSR-------------------QSHHWSEND 168
            |....|    ||  |.:..:..|....:|:||...:|                   ......::.
Zfish   269 PKVRPS----SY--SCEEENCAPPQPPMRKESFRATRGQATDKRCVSAPVGIPNVSSCTDEDQSQ 327

  Fly   169 LSSVCSNSVAPSPI-------------PLLARQSHSHSHSHAHSHSNSHGHSHGHAHSASSSSSS 220
            :..|.:..|..:.|             |.....|.|.....|..|...|...:..:.:|:||..|
Zfish   328 IQDVLTGRVYLNGIQDSEPERKGCSIQPYYTLNSDSGGDGKATDHEKEHLEDYSKSVAAASSPPS 392

  Fly   221 NNNSN-------------GSATNNNN---------------NNSSESTSSTETLKWLGSMSDISE 257
            ..|.:             .||.|.::               :......|::.|.:|..|...:|:
Zfish   393 QRNRDENFDTKLRPEHDLQSAMNRHSAPEKLLAAQLCMMDVSADKSDHSASPTCQWSQSPLYLSD 457

  Fly   258 ASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQG-----DSSPTASNSSQMM 317
            :|..|.......|..|:...|.:|.|..| |...||:   ......|     ..||..:..||
Zfish   458 SSQNTEQGKWGTSRCSTPGSVATSEVEDP-RLEEESI---DGQNPWGHPISLSGSPIGNGFSQ-- 516

  Fly   318 ISEEANGEE-------SPPSVQPLRIQHRHSPS--YPPVHTSMVLHHFQQQQQQQQDYQHPSRHH 373
             :.|.||.|       .|.  ||.:.|.|.|.|  ......:.:.:..|:::.|.|..::|....
Zfish   517 -NSENNGGEVMLDDGLGPK--QPQKRQFRCSKSRRRSERFATNLRNEIQRKKAQLQKSRNPCGEE 578

  Fly   374 TNQSTLSTQSSLLELASPTE----KPRSLMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVT 434
            |.:..:...::  |:.:|.|    ||:.|...:.:...:|...|....:...:..:::.|:..|.
Zfish   579 TVEEEVGDFNT--EVVAPPEYRQHKPQILPKPATNTVPIQISKPATQKVFDATQTEEYSSARVVC 641

  Fly   435 ISSSEAVVTIAPQ-------------PPAGKP--------SKLQLSLGKSEA------------- 465
            ..:|: ..|..||             .|||||        .||:|....||:
Zfish   642 FQTSQ-TQTQVPQHVRQVCVHVVEEVAPAGKPRRWRWTPERKLELENESSESKRNETIGQMWSGK 705

  Fly   466 -------LSCSTPNMGEQSPTNSIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKS 523
                   .|.|:..:| :|....|..:....|.|          ..||:.:.......|:...:|
Zfish   706 MESTRSRTSSSSGRLG-RSDDCDILPFADRRRFF----------EETSRKLSQSVTNLSNLTSRS 759

  Fly   524 AKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKFAYLEPTKTHRLSNP----ALKALQKNA 584
            .:|...........|..|.:|        :.||. .:|:|.:....:.|.|.    :.:..|:..
Zfish   760 QRLDKPGRMNHPSSPEPHEIA--------AHLGR-RRFSYQDVPYINSLDNGRQFISNQQDQEKT 815

  Fly   585 VQSYVERQQQQQKE-----EQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCS 644
            .|..:||:|::::|     ||:.||...:..:....||::....|
Zfish   816 RQRLIEREQEREREQERLKEQEKLREQEREKERLRKERENEQQRL-------------------- 860

  Fly   645 SPTPPPPPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPP 709
                                     .|:.|.:.|.|.:.:.:  |:|...::|
Zfish   861 -------------------------KDWEERQRLLQREQEWE--SVRESVHSE------------ 886

  Fly   710 PPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPPHVPPERPPKHPNL 774
                        ..|||.|                :.|...|....:  ||
Zfish   887 ------------HNTSSDT----------------VPHSLSHDVYRK--QP-------------- 907

  Fly   775 RVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPP--PSPNRRNCFAGASTRRTTYEAPPP 837
              |||::|    |.|.:|    |||.......|.:|...  |...:.|.:.|       |:..||
Zfish   908 --PSPQIP----SSLQMS----EPLYSSTTTNVQKPCSAFHPVTTQHNRYDG-------YQVNPP 955

  Fly   838 TAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTA 902
                                            ..|.:.||
Zfish   956 --------------------------------YNPRNYTP------------------------- 963

  Fly   903 HDNVIASNLESNQQKRSNSKASYLPRQ-SLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTG 966
                              .:|.|:..| ...|:|.        ..:||..:
Zfish   964 ------------------DEAQYVREQEKTRKINR--------NFSLTERD-------------- 988

  Fly   967 KLPNNLPDVLPLGVKLHQQPKLQPGSPNGDANVT--LRYGSNNNLTGNSPTVAPPPYYGGGQRYS 1029
             .|.:..|.           |...|     |||.  :|.|.|:..:|.:.           :...
Zfish   989 -YPRSRRDF-----------KTVDG-----ANVPGFVRTGGNSITSGRNE-----------EHLF 1025

  Fly  1030 TPVLGQGYGKSSKPVTPQQY-TRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPTA 1093
            ||:..:...:::..|..|.| ..|.|..|....:.|:..:.::.|           ::.|:....
Zfish  1026 TPLRNRAMSENNLCVETQHYQNHSSSSGVSRMRSSTLSDLDENTV-----------SVGEIKKKK 1079

  Fly  1094 TPTPTPTPTPTPPRLSP-----ASSHSDCSLSTSSLECTINPIATPIPKPEAHIFRAEVISTTLN 1153
            .|   |.|.|.||:...     ||.||..| |||...   :|.|:| |:|:..         |..
Zfish  1080 GP---PPPRPPPPKWDQFHKRRASHHSLFS-STSHYS---SPTASP-PRPQPQ---------TCT 1127

  Fly  1154 TNPLTTPPKPAMNRQESL----RENIEKITQLQSVLMSAHLCDASLLGGYTTPLIT----SPTA- 1209
            :.|   |....|:||.|.    |:..|          |.|.|........::|..|    .|.|
Zfish  1128 SRP---PSVSEMSRQRSYSLPPRDMSE----------SLHCCRQEYSVAPSSPAFTRRAFKPVAL 1179

  Fly  1210 ------------SFANEPLMTPPLPPSPPP---------PLEPEEEEEQEENDVH------DKQP 1247
                        ....||....|:.|:..|         |..|:...|.:.:..|      .:.|
Zfish  1180 PPREMDYNTRREVHQPEPCTRIPIHPAAAPEEPRATHLKPTFPDHGVEWDRSSPHYPTHGTSRTP 1244

  Fly  1248 EIE--------------------ELQLMQ--------RSELVLMVNPKPSTTDMACQTDELEDRD 1284
            |:.                    :||..|        :::::....|:.....:....||:.:.:
Zfish  1245 EVPSNSFSAGPLCPESYFSMNNFQLQPQQAGFPITAHKTQIIPSQGPEDGDLPLETDIDEICENE 1309

  Fly  1285 TDLEAAREEHQTRTTLQ--PRQRQPIELDYEQMSRELVKLL-----PPGDKIADILTPKICKPTS 1342
               :|.|:|...|..:|  .|....:|.|.:....|.....     |.|..:..||..:......
Zfish  1310 ---QAERKETVDRMEMQGFARPVMVLETDIDHTPEEAAPSAISIRGPRGSLVDSILEDEYGVSRK 1371

  Fly  1343 QYVSNLYNPDVPLRLA------KRDVGTSTLMRMKSITSSA---------EIRVVSVEL-----Q 1387
            :.:..|:...|...::      ...:...||.|...:.::|         :|...:.:|     :
Zfish  1372 ELLGELFPHSVNAEMSGDGWRGGYPISGGTLERPSRLNTTAPQVSRSTCYDISADNPQLLAKLRE 1436

  Fly  1388 LAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKVRPSEAS 1452
            ::|..||...|..:|  :|::.|.:|:..|:..|:.:.|:..||.:||.::.:.:....:|:|..
Zfish  1437 ISERKEEDEELNYKK--QLMESLRKKLTVLREAQRGLQEDIRANAQLGDEVESLVLAICKPNEVD 1499

  Fly  1453 KFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQERGALESKRDLLYEQMEEAQRLKSD 1512
            |:|..:..:..:||||||||.||.:.||:|     ||..|||..|..|:..|..||.|||.||..
Zfish  1500 KYRMFIGDLDKVTSLLLSLSGRLIRVESALDCVDPETGHQERLQLLEKKKQLLVQMGEAQELKEH 1564

  Fly  1513 IERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 1571
            ::||..::..:|...|:.:...||.:|:.|||.|:.:.|.|..:|:..||||..|.::|
Zfish  1565 VDRREQAVCRVLGCCLTPEQMRDYGHFVKMKAALLVEQRQLDDKIRLGEEQLRGLRESL 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	79/281 (28%)
shroom4	XP_005172390.1	PDZ_signaling	12..91	CDD:238492
shroom4	XP_005172390.1	ASD2	1372..1622	CDD:285850	74/251 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592777
Domainoid	1	1.000	112	1.000	Domainoid score	I6135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25110
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030