DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shrm and shroom2b

DIOPT Version :9

Sequence 1:	NP_001097307.1	Gene:	Shrm / 36592	FlyBaseID:	FBgn0085408	Length:	1576	Species:	Drosophila melanogaster
Sequence 2:	XP_005172997.2	Gene:	shroom2b / 556551	ZFINID:	ZDB-GENE-130819-2	Length:	1431	Species:	Danio rerio

Alignment Length:	1559	Identity:	313/1559 - (20%)
Similarity:	532/1559 - (34%)	Gaps:	481/1559 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 SVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEK 394
            |::..|.:.|:..|..|       |.:...:..:....:.|:...|.:...|..:..:..|||::
Zfish    29 SMRKNRFKGRNESSCRP-------HSWHSAKSSESSNPNDSKSEPNPAPDPTWQTKCDPGSPTKE 86

  Fly   395 PRSLMGQSH---------SMGDLQQKNP------HQNPMLGR-SAGQQH---KSSISVTISSSEA 440
            ..|..||::         |:.:::...|      .:.|:..: :.|..|   :|:||.......|
Zfish    87 FTSCWGQTNLRQASCQFSSVRNMESVEPSSHAFSKEQPLTSKPNGGADHEVLESAISKPALPGNA 151

  Fly   441 VVTIAPQ--PPAGKPSK-----------------LQLSLGKSEALSCSTPNMGEQSPTNSIDSYR 486
            ....|..  |....|::                 ||:.:|....:|   |::.|||.:....:.|
Zfish   152 FSGTADHGAPRGANPTEGVFYRGDLTVPSDCHRYLQIPIGNGGRVS---PSVEEQSSSRLSSTAR 213

  Fly   487 SNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSG------LHKSAKLPVITPAGATV----QPTWH 541
            ||||  ||....|   :..|.....|.|...|.      :|:.: |..:.|.|.||    :|...
Zfish   214 SNHR--PVWHIPE---NKMSSSEAPPAPPLRSDSFTATRVHEKS-LVGLFPEGHTVYPLQRPPCR 272

  Fly   542 SVAERINDFERSQLGEPPKFAYLE-------------PTKTHRLSNPALKALQKNAVQSYVERQQ 593
            :|..::.|. |.....|||..|||             |||...||:..::..| |...|..:.|:
Zfish   273 AVDRQLEDV-RHSYNSPPKKDYLEPYLPVEDYPNQLNPTKLFSLSSTDVRQGQ-NPFASEFQHQR 335

  Fly   594 QQQKE------EQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSP------ 646
            |...:      ........|||..:.:...:.||||:|        ..|...|.....|
Zfish   336 QHSDDSPFSVYNNSTCSSKSQSVGSYYRSLQDLPNNVS--------NQNKTRTSTVFDPNHDGQA 392

  Fly   647 -------TPPPPPRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDC 704
                   |...|...|.|....:..:||.             .|:.:|.:.|:...::|:.
Zfish   393 HFRYYCITAQQPYLESSSHCRMVDEQSSE-------------MGKAQGATDRSFVGSQKVI---- 440

  Fly   705 GMPPPPPPPRGRLAVPTRRTS-----------SATEYAPMRDKLLLQQAAALAHQQ---HHPQQH 755
                ....|:..|::|..:.|           ||...:|:.:.|:.:.::.....|   ..||..
Zfish   441 ----KAKHPQLYLSLPENKRSNGYNKQSISPASAQAVSPISNNLISKHSSVERETQKKKDKPQPS 501

  Fly   756 RHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLP----------PPPPPEVLQP 810
            ||.          |.|              |:|.:..||:....|          |...|.:...
Zfish   502 RHI----------PNH--------------QTEQNSMYTYQHDNPWISKQDLKICPHKTPLLHSL 542

  Fly   811 RPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHA 875
            .........|....|| :..::|:..                         |:.|...|:...:|
Zfish   543 AQESKKMAENSITTAS-KGGSHESSD-------------------------ASSGKLGRRSDRYA 581

  Fly   876 TPQPILENVASPVAPPPPLLPRARSTA---------HDNVIASNLESNQQKRSNSKASYLPRQSL 931
            |      .:...:......|.::||.|         .|:.|   .:||:...|:|..|:
Zfish   582 T------TLRKEIQKKRAQLQKSRSAATLTCSTEVEEDSDI---WKSNETSTSSSDGSF------ 631

  Fly   932 EKLNNTDPDH------GIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDV--------LPLGVKL 982
               .||..||      .:.:.|....:||  ....:..|:.:||.....|        .|:..|:
Zfish   632 ---TNTYKDHLKEAQAKVLQATSFMRKDL--ELPGNEVVSAQLPKRPGQVTRIGGRKRFPMDKKI 691

  Fly   983 HQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKS--SKPVT 1045
            |...  :|...|       ..|..:...|:.           ..||.   ..:|.||:  .||:.
Zfish   692 HSFS--EPDKIN-------EVGVEDKAGGSF-----------ADRYK---FFEGSGKAVVQKPIP 733

  Fly  1046 PQ-------QYTRSQSYDVKHTSAVTMPTMSQSHVDL----------------------KQAA-- 1079
            .|       .::..::.:.:....|.:.....||.||                      ||..
Zfish   734 KQSLLGPTVDHSERKTGEAESIPRVLLKQSKSSHSDLNADEQQRLGTFAEYEATWNLQKKQVERR 798

  Fly  1080 -----HDLETTLEEVL------------PTATPT-----------PTPTPTPTPP--------RL 1108
                 |..|..|:..|            ..::|:           |...|..:||        .:
Zfish   799 NTGRYHSAENILDSGLEESNSALCVHERSRSSPSADFYGQKLPLPPRKLPLDSPPEAKDQQEAHI 863

  Fly  1109 SPAS---------SHSDCSLSTSSLECTINPIA------------TPI--------------PKP 1138
            |.||         |.|..|::.|.|:.::.|:.            .||              ||.
Zfish   864 SSASEKEHNALNISKSQESITMSILDNSVEPLGYNQKSRSDTKQPAPITSQHLQVPMSEQLLPKN 928

  Fly  1139 EAHIFRAEVISTT------LNTNPLTTPPKPAMNRQESLRENI-EKITQLQSVLMSAHLCDASLL 1196
            ...|.:.:.:.||      |.....|..|:|.   ||.||.|. |.:.......:..|..:..|
Zfish   929 NGLIPQHKELETTCPIMASLEVRIQTFSPEPT---QERLRLNTSEPLDGDMHAQVDEHKSERML- 989

  Fly  1197 GGYTTPLITSPTASFANEPLMTPPLPP---------------SPPPPLEPEEEEEQEENDVHDKQ 1246
                :|:..:...|         |:||               ||.|...|:...::...:|:.|.
Zfish   990 ----SPIPHNSAGS---------PIPPKQKADLTVTSASRTRSPSPQFFPQRLTDEPPANVYKKD 1041

  Fly  1247 P---EIEELQLMQRS---ELVLMVNPKP---------STTDMACQTDELEDRDTDLEAAREEHQT 1296
            |   ::||.....|.   ::|...|...         |.:....||.:|:    .||::.:.|..
Zfish  1042 PCSSKVEEPNTPGRKVPIQIVCTENGSERDIRNYLLHSESSEEPQTGQLK----TLESSEQCHAP 1102

  Fly  1297 RTTLQPRQRQPI------------------ELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQ 1343
            ......:..:||                  :|..|:::|:   ::.....:.|||..:..|.|..
Zfish  1103 FIAYSNQIEEPILDPFKPMRSNGVSEHSEDDLKREELARD---IMGKDRSLVDILDQRKMKTTMD 1164

  Fly  1344 YVSNLYNPDVPL---------RLAKRDVGTSTLMRM-KSITSS----------------AEIRVV 1382
            .:..::.....:         ..:|:....:...|| :|::||                ||:.:.
Zfish  1165 LMEGIFPQGEQILEGAQQRRKAASKQTSPKNAQQRMEESLSSSVSLVSSSSYYSTSAPKAELLIK 1229

  Fly  1383 SVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKVR 1447
            ..::|..:..:|.|..:..|..||:..|::|:..|:..::::.|:...|:.||:::.|.:....|
Zfish  1230 MKDMQEQDSEDELTTDLSSKKQELMDSLSKKLQVLREARESLQEDVQDNNALGEEVEATVQSVCR 1294

  Fly  1448 PSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLE-----TRQQERGALESKRDLLYEQMEEAQ 1507
            .:|..|||..|..:..:.|||||||.|||:.|::|:     |...|:..|..||.||..|.|:|:
Zfish  1295 ANELEKFRMFVGDLDKVVSLLLSLSGRLARVENALDNLEEGTSADEKQTLTEKRRLLIGQHEDAK 1359

  Fly  1508 RLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 1571
            .||.:::||...:..:|......:..|||.:|:.||:.||.:.|.|..:||..||||..|.::|
Zfish  1360 ELKENLDRRERVVYEILTGYFREEQLADYRHFVKMKSALIIEQRKLEDKIKLGEEQLKCLKESL 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	77/282 (27%)
shroom2b	XP_005172997.2	ASD1	594..721	CDD:312273	31/163 (19%)
shroom2b	XP_005172997.2	ASD2	1138..1422	CDD:312272	78/286 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6135
eggNOG	1	0.900	-	-		E1_28N8R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004714
OrthoInspector	1	1.000	-	-		otm25110
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.000