Protein Alignment Shrm and shroom2a

DIOPT Version :9

• Sequence 1: NP_001097307.1
• Gene: Shrm / 36592
• FlyBaseID: FBgn0085408
• Length: 1576
• Species: Drosophila melanogaster
• Sequence 2: XP_017212121.1
• Gene: shroom2a / 386817
• ZFINID: ZDB-GENE-050208-128
• Length: 1717
• Species: Danio rerio
• Alignment Length: 1839
• Identity: 385/1839 - (20%)
• Similarity: 610/1839 - (33%)
• Gaps: 553/1839 - (30%)

  Fly     3 MRNHKENGNGSEMGESTKSLAKMEPENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSSA---- 63
            ||.::..|....|.......|....|.:::....|....:.:....|:|.||..:..:...
Zfish   154 MRKNRFKGRNEPMSRPHSWHATKFNETHSEAKTQSTPSPVWQTRYDASSFSSELSTGWDQTNLRR 218

  Fly    64 -----SVAGSVQDDLPH---------------HNSSSSQLGQQHGSSLDQCGLTQAGLEEY---- 104
                 |..||: |.|.|               :|:|...||.....|......|.:|..:|
Zfish   219 VSDQFSSLGSM-DSLEHSSHPYPPGRLSPNKSNNNSIEHLGSGKRDSAYSSFSTSSGTPDYTLSK 282

  Fly   105 NNRSS--------SYYDQTAFHHQKQPSYAQSE--------GYHSYVSSSDSTSATPFLDKL--- 150
            :|.:|        :.:|.:|.|...:.|...||        ||..::||: .....|..::|
Zfish   283 SNTASTENMLYKINQWDSSARHSNGRHSQNLSEGVRQDERPGYLHHLSST-GNHEIPRAEELPGN 346

  Fly   151 RQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAH-------SHSNSHGHSH 208
            |..|.........|...|:.   .|.::.:|.|....:|.|.:.:..|       :.....|||.
Zfish   347 RHSSSGRVNIGPVWHVPDMK---KNMISSTPPPTPPTRSDSFAATKVHEKGLITGTSEGLGGHSQ 408

  Fly   209 -----------GHAHSASSSS-----------------SSNNNSNGSATNNNNNNSSESTSSTET 245
                       |..|.::..|                 |.|::||...::::::...:.|||.:|
Zfish   409 VKPQAKPQQKPGETHESTQRSNQVIEICLEGRRDYNLQSKNDSSNSCISSDSHHQYIQRTSSDKT 473

  Fly   246 LKWLGSMSDISEASHATGYSAISESVSSSQRIVHS---SRVPTPKRHHSESVLYLH-NNEEQGDS 306
            ...  |.:||.::..:.|::.......|.:...|:   :.:..|...:..|:..|| ||..|.:|
Zfish   474 YSL--STTDIRDSHPSYGHAPYHAQQYSDEGTFHAQTRTAMKPPFSGYFSSMQELHTNNHMQLNS 536

  Fly   307 S-----PTASNSSQMMISEE--ANG----------EESPPSVQPLRIQHRHSPS----------- 343
            .     |.||.|..:.::..  :.|          :....||..:....|...|
Zfish   537 QNQTGRPAASLSVNLGVNSHHISQGLTQASLMRADDSKASSVSEMSHNGRDRMSIGSQGGNKERY 601

  Fly   344 YPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMG---QSHSM 405
            :||          |.|....::.....:.:.||..:|..|:.|.::..| |...|.|   |.|..
Zfish   602 FPP----------QSQHHDNKERSASFKQNENQHYVSAPSNPLNMSDST-KHNELRGCQKQHHVH 655

  Fly   406 GDLQQKN---PHQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALS 467
            |..:...   |.:.|...||||..|....|.....:::...|.||.   .|....|:.|.::...
Zfish   656 GSDELSGSYPPSKQPEHRRSAGHLHHKEYSQQPFPTKSESKICPQK---TPMLYSLAQGHNDTDD 717

  Fly   468 CSTPNMGEQSPTNSIDS-----YRSNHRL-------------------------FPVSTYTEPVH 502
            ||.......:...::||     .|.|.|.                         .||.|..|...
Zfish   718 CSNQIKSGSAQHEALDSLSSKQVRRNDRFATTLRNEIQMRRAHLQKSQSAATLESPVETVEESAL 782

  Fly   503 SNTS-------------QYVQHPKP------QFSSGLHKSAKLPVITPAGATVQPTW-----HSV 543
            ..|:             .|..|.|.      |.:|...|..: ||:.....|..||.     .||
Zfish   783 WKTTGTASPSSDGCFSISYKDHLKEAQARVLQATSFRRKDLE-PVLFEHPGTEGPTRKDVPPSSV 846

  Fly   544 AE--------------RINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQ 594
            :|              ||...:|.. .|....::.||.|.|.:.......:.:|.  :::|.||:
Zfish   847 SEVTPSKPTSGSNHVLRIGGRKRIS-AEKKVTSFSEPDKIHEVGADERSTMPENV--AHLENQQR 908

  Fly   595 -------------------QQKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSAST 640
                               |..|:.:|.:|....|.|                     .|:.|..
Zfish   909 FFETTGKPVFPKPMPKQNLQISEDPRLSKPGGMHYSA---------------------NSDMAGR 952

  Fly   641 RDCSSPTPPPPPRRSGSLLPN-----LLRRSSSASDYAEFRELHQAQGQVKGPSIR-NISNAEKI 699
            .:..|.||.......|...||     .|........:||:......|.:...|.:. ...:|:.|
Zfish   953 NNGESSTPIEHHINEGLDGPNSVNHQALLEQQRLGTFAEYEAKWNTQRKTTEPRVSGRYHSADNI 1017

  Fly   700 SFNDCGMPPPPPPPRGRLAVPT------RRTSSATEYA---PMRDKLLLQQAAALAHQQHHPQQH 755
            .  |.|        :.|.:.||      |.:.||..|.   |.::|   :.|.....::...||.
Zfish  1018 L--DTG--------KERRSNPTCVHERSRSSPSADFYGQKLPPQEK---KSADCFKSEKSPCQQD 1069

  Fly   756 RHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRN 820
            :::...:..|....:|.:.......|.....||:   ...::|..||..||.....||.|.::..
Zfish  1070 KNSTSQNFYPSVSLEHSHWFYTPSRLNEKGYSEI---LCKEKPETPPEEPEKKTVDPPSSHHKPA 1131

  Fly   821 C-FAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENV 884
            . |...|||      ..|:|:...|...|:|.                             ||..
Zfish  1132 LHFPVHSTR------SEPSALSKNKSSFLLPH-----------------------------LEKY 1161

  Fly   885 ASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLT 949
            ..|...||||              ||:   |:.:..|:...|  ..:..:||
Zfish  1162 KCPEGTPPPL--------------SNI---QEVQPGSQGGAL--APISPVNN------------- 1194

  Fly   950 SNEDLVAHTKPSYGVTGKLPNNLPDVL--PLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTGN 1012
                     :.|..|:..:|...|:..  |:|.:...|..:.|..|
Zfish  1195 ---------QSSAPVSAPIPWKSPEYSKGPVGEEEQHQELVPPPFP------------------- 1231

  Fly  1013 SPTVAPPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQ 1077
                 |||         .||           |.|.|          .|:..|.|||....
Zfish  1232 -----PPP---------PPV-----------VLPTQ----------QTAGPTQPTMDGQR----- 1256

  Fly  1078 AAHDLETTLEEVLPTATPTPTPTPTPTPPRLS--PASSHSDCSLSTSSLECTINPIATPIPKPEA 1140
                                :|:|...|.||:  |..|.|....:...:: .|....|.:.|...
Zfish  1257 --------------------SPSPQFAPQRLTDKPPVSVSSQDEAPGRMD-QIKDENTSVKKVPI 1300

  Fly  1141 HIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDA-------SLLGG 1198
            .|..:|..:...:...|..|.:..:|.|.               |:.|||...       ||...
Zfish  1301 KIVHSESDTEKESRQYLDLPSETPVNSQG---------------LVGAHLQSLGNPDQSYSLFCT 1350

  Fly  1199 YT-----TPLITSP---------------TASFANEPLMT-PPLPPSPP----PPLEPEEEEEQE 1238
            ||     .|.:..|               ..|:....|.| |||..|..    .|...|:::.:|
Zfish  1351 YTRQKDQVPGLRDPDMGPLKDQGPQSNINPVSYVEPGLQTGPPLDQSTNGVSLHPSHSEDDKRKE 1415

  Fly  1239 -ENDVHDKQPEIEEL--QLMQRSELVLMVNPKPSTTDMACQTDELEDRDTDLEAAREEHQTRTTL 1300
             ..|:.||...:.::  |...::.:.||....|       |.|:|          .||.|.|...
Zfish  1416 LARDIMDKDKSLADILDQSKMKTTMDLMEGIFP-------QGDQL----------LEEAQQRRKA 1463

  Fly  1301 QPRQRQPIELDYEQMSRELVKLLPPGDKIADILTPKICKPTSQYVSN--LYNPDVPLRLAKRDVG 1363
            ||:...|         |..|:.......:|          .:..|||  .|:...|    |.::
Zfish  1464 QPKPLSP---------RNSVEKKEEDSLVA----------AAALVSNSTYYSTSAP----KAEL- 1504

  Fly  1364 TSTLMRMKSITSSAEIRVVSVELQLAEPSEEPTNL-IKQKMDELIKHLNQKIVSLKREQQTISEE 1427
               |::||.:...      |||....|..||.... :..|..|||:.|::|:..||..|:::.|:
Zfish  1505 ---LIKMKDMQDQ------SVEHNSEEELEEDNESDLACKKHELIESLSKKLQVLKEAQESLQED 1560

  Fly  1428 CSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQ-----Q 1487
            ...|:.||:::.|.:....:|:|..|||..|..:..:.:||||||.|||:.|::|.:.:     :
Zfish  1561 VQDNNALGEEVEAIVQGVCKPNELDKFRMFVGDLDKVVNLLLSLSGRLARVENALNSLEEDASLE 1625

  Fly  1488 ERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARD 1552
            ||..|..||.||..|.|:|:.||.:::||...:..:||..|..:..|||::|:.||:.||.:.|.
Zfish  1626 ERRTLTEKRKLLIRQHEDAKELKENLDRRERVVYDILASYLPEESMADYEHFVKMKSALIIEQRK 1690

  Fly  1553 LAVRIKGSEEQLSSLSDAL 1571
            |..:||..:|||..|.|:|
Zfish  1691 LEDKIKLGDEQLKCLMDSL 1709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	81/259 (31%)
shroom2a	XP_017212121.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004714
OrthoInspector	1	1.000	-	-		otm25110
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9829
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.030