DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shrm and SHROOM2

DIOPT Version :9

Sequence 1:NP_001097307.1 Gene:Shrm / 36592 FlyBaseID:FBgn0085408 Length:1576 Species:Drosophila melanogaster
Sequence 2:NP_001640.1 Gene:SHROOM2 / 357 HGNCID:630 Length:1616 Species:Homo sapiens


Alignment Length:1741 Identity:360/1741 - (20%)
Similarity:576/1741 - (33%) Gaps:528/1741 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 LDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHS---HSHS-HAHSHSNSHGHS 207
            |...|||:..|.:.||                 ..:.|:.::...   ..|| ||...|:||...
Human    82 LSGFRQEAICLVKGSH-----------------KTLKLVVKRRSELGWRPHSWHATKFSDSHPEL 129

  Fly   208 HGHAHSASSSSSS-NNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHATGYSAISESV 271
            .....:::|...| :...:.|:::::.::|.|.|:...||....|:..:....|.:...::::|.
Human   130 AASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSN 194

  Fly   272 SSSQRI-VHSSR----------VPTPKR-------HHSESVLY---LHNNEEQGDSSPTASNSSQ 315
            ||...: .||.|          ..||..       ..:|::||   |.....||.....|:...|
Human   195 SSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQ 259

  Fly   316 MMISEEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQSTLS 380
                    |.|...|..|.|:.........|.:.:            :.....|.|.:.......
Human   260 --------GSEEKLSCFPPRVPGDSGKGPRPEYNA------------EPKLAAPGRSNFGPVWYV 304

  Fly   381 TQSSLLELASPTEKPRSLMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTISSSEAVVTI- 444
            ....... :||...|..|  :|.|....:.....|.|:...:|..||.::::......:....: 
Human   305 PDKKKAP-SSPPPPPPPL--RSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELT 366

  Fly   445 --------------------APQ--------PPA--GKPSKLQLSLGKSEALSCSTPNMGEQSPT 479
                                .||        ||:  |..|:||.||..|:.....:|:.|...|.
Human   367 DRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPL 431

  Fly   480 NSIDSYRSNHRLFPVSTYTEPVH--------------SNTSQYV----QHPKPQFSSGLHKSAKL 526
                 |..:..|...|...||..              |:..|.:    |.|:|.....| ::|:|
Human   432 -----YSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDL-QAAQL 490

  Fly   527 -----PVITPAGATVQPTWHSVAERINDFERSQLGEPPKFAYLEPTKTHRLSNP----------A 576
                 |..|..||            :.......:|:.|:         |.|..|          .
Human   491 WAGCWPSDTALGA------------LESLPPPTVGQSPR---------HHLPQPEGPPDARETGR 534

  Fly   577 LKALQKNAVQSYVERQQ-----QQQKEEQQLLR----PHSQSYQACHVERKSLPNNLSPIMVGLP 632
            ...|.|.|.......|:     :.:|..|:|..    ...:|.:.|..|        :|::..| 
Human   535 CYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQE--------TPLLHSL- 590

  Fly   633 TGSNSASTRDCSSP----TPPPP-------PRRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVK 686
              :.....|..|||    |.|||       |.|........||...         ::|:|:.|..
Human   591 --TQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEI---------QMHRAKLQKS 644

  Fly   687 GPSIRNISNAEKISFNDCGMPPPPPPPRGRLAVPTRRTSSATEYAPM----RDKLLLQQAAALAH 747
            ..::...:..|  :.:..|        |.|..:     ...|:..|:    :|.|...||..|..
Human   645 RSTVALTAAGE--AEDGTG--------RWRAGL-----GGGTQEGPLAGTYKDHLKEAQARVLRA 694

  Fly   748 QQHHPQQHRHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRP 812
            ...   :.|...|.  |.:..|:....|:..|:..|         :.::..|..||......|.|
Human   695 TSF---KRRDLDPN--PGDLYPESLEHRMGDPDTVP---------HFWEAGLAQPPSSTSGGPHP 745

  Fly   813 PPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATP 877
            |....|         ||.|.|                 :|..|.......|..|.:|....|..|
Human   746 PRIGGR---------RRFTAE-----------------QKLKSYSEPEKMNEVGLTRGYSPHQHP 784

  Fly   878 QPILENVAS---------PVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNSKASYLPRQSLEK 933
            :...:.|.:         ..:.|.|..|..:...|      .:..::.:|        ||.:...
Human   785 RTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALH------GIPRDKPER--------PRTAGRT 835

  Fly   934 LNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNL-------------------------- 972
            ...|:|    :..|.:..:.|.||:......|..||..|                          
Human   836 CEGTEP----WSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCH 896

  Fly   973 --PDVLPLGVKLHQQPKLQPG----SPNGD-----ANVTLRYGSNNNLTGNSPTVAPPPYYGGGQ 1026
              .|:|.:.:...::|:...|    ||:.|     |:|.||..:.:   ...|....|......:
Human   897 SADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGD---PGEPREELPSAVRAEE 958

  Fly  1027 RYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQ-SHV----DLKQAAHDLETTL 1086
            ..|||.......:...|.: ||:..||       .|...||.|: ||.    :|.:.......||
Human   959 GQSTPRQADAQCREGSPGS-QQHPPSQ-------KAPNPPTFSELSHCRGAPELPREGRGRAGTL 1015

  Fly  1087 -------EEVLPTATPTPTPTPTPTPPRL-SPAS-----SHSDCSLSTSSLECTINPIATPIPKP 1138
                   ||          .||....||. ||.|     ......:|::.|.....|...|.||.
Human  1016 PRDYRYSEE----------STPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKR 1070

  Fly  1139 EAHIFRAEVISTTLNTNPLTTP----------PKPAMNRQESLRENIEK--ITQLQSVLMSAHLC 1191
            |...:||      .:..|...|          |.||     ||...:.:  ::...||..||...
Human  1071 EPRRYRA------TDGAPADAPVGVLGRPFPTPSPA-----SLDVYVARLSLSHSPSVFSSAQPQ 1124

  Fly  1192 DASLLGGYTTPLIT------SPTASFANEPLMTPPLPP----------------SPPPPLEPEEE 1234
            |        ||..|      ...:..|:.||....|||                ||.|...|::.
Human  1125 D--------TPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKL 1181

  Fly  1235 EEQEENDVHDK-QPEIEELQLMQRSELVLMV---------NP-KPSTTDMACQTDE------LED 1282
            .::....:.|: ...||  ::|..:..|.||         .| |.|...:||..:.      ||.
Human  1182 TDKPPLLIQDEDSTRIE--RVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEK 1244

  Fly  1283 RDTDLEAAREEHQTRTTL--------------QPRQRQPI------------------------- 1308
            ......:..|:..:|..|              ||.:.||:                         
Human  1245 DQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEK 1309

  Fly  1309 ---ELDYEQMSRELVKLLPPGDK-IADILTPKI-CKPTSQYVSNLY------------------- 1349
               :|..|:::||:|    ..|| :||||.|.: .|.|...:..::                   
Human  1310 TVEDLKSEELAREIV----GKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPK 1370

  Fly  1350 ------------NPDVP--LRLAKRDVGTSTLMRMKSITSSAEIRVVSVELQLAEPSEEPTNL-- 1398
                        .|.||  :.||......||      ....||:.:...:||..:..||.:..  
Human  1371 IPSPRSTEERKEEPSVPAAVSLATNSTYYST------SAPKAELLIKMKDLQEQQEHEEDSGSDL 1429

  Fly  1399 ---IKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDA 1460
               :..|..|||:.:::|:..|:..::::.|:..||..||.::.|.:....:|||..|||..:..
Human  1430 DHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGD 1494

  Fly  1461 VGNITSLLLSLSERLAQTESSLETRQQ-----ERGALESKRDLLYEQMEEAQRLKSDIERRGVSI 1520
            :..:.:||||||.|||:.|::|.....     :|.:|..|:.:|.:|.|:|:.||.:::||...:
Human  1495 LDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIV 1559

  Fly  1521 AGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 1571
            ..:||..||.:..|||::|:.||:.||.:.|:|..:|...||||..|.|:|
Human  1560 FDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSL 1610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShrmNP_001097307.1 ASD2 1318..1570 CDD:285850 84/296 (28%)
SHROOM2NP_001640.1 PDZ_signaling 25..105 CDD:238492 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..159 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..229 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..475 44/255 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..678 40/231 (17%)
ASD1 640..802 CDD:285851 38/216 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..790 25/134 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 802..869 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 881..1100 51/245 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1115..1184 18/76 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1268..1302 4/33 (12%)
ASD2 1318..1609 CDD:285850 85/300 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1363..1389 3/25 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 110 1.000 Domainoid score I6298
eggNOG 1 0.900 - - E1_28N8R
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 146 1.000 Inparanoid score I4429
Isobase 1 0.950 - 0 Normalized mean entropy S7071
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004714
OrthoInspector 1 1.000 - - otm41129
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15012
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9829
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
99.030

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