Protein Alignment Shrm and Shroom2

DIOPT Version :10

• Sequence 1: NP_001097307.1
• Gene: Shrm / 36592
• FlyBaseID: FBgn0085408
• Length: 1576
• Species: Drosophila melanogaster
• Sequence 2: NP_001041358.2
• Gene: Shroom2 / 317435
• RGDID: 1565163
• Length: 1491
• Species: Rattus norvegicus
• Alignment Length: 1692
• Identity: 349/1692 - (20%)
• Similarity: 572/1692 - (33%)
• Gaps: 536/1692 - (31%)

  Fly   135 VSSSDSTSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHS-HAH 198
            |:.:|.|     |...|||:..|.:.||    ..|..|......||..|          || ||.
  Rat    75 VAINDVT-----LSGFRQEAICLVKGSH----KTLKLVVKRKSDPSWRP----------HSWHAT 120

  Fly   199 SHSNSHGHSHGHAHSASSSSSS-NNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHA- 261
            .:.:.|..........||||.| .:....|:::::.:.|.|.||...|.....||..|....|:
  Rat   121 KYFDVHPEPPVSLFLNSSSSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSS 185

  Fly   262 ----TGYSAISESVSSSQRI-VHSSR-----------------VPTPKRHHSESVLY-------- 296
                :|:.:.::|.||...: .||.|                 :|......:|::||
  Rat   186 QLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEAS 250

  Fly   297 ----LHNNEEQGDSSPTASNSSQMMISEEANGEESP---PSVQPLRI---------------QHR 339
                ...::..||........|..:.....|..:||   .:::| :|               ..:
  Rat   251 RPGSSRQSQSTGDPQGLQDRPSSFLPRVPGNSSKSPRPEDNIEP-KIATSGRSNFGPVWYVPDKK 314

  Fly   340 HSPSYPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQ-----STLSTQSSLLELASPTEKPRSLM 399
            .:||.||:...:          :...:...:|.|...     |.|::......|  |..:||.
  Rat   315 KAPSPPPLGLPL----------RSDSFAVAARGHEKARGPPFSDLASMQHFTTL--PHVQPRG-- 365

  Fly   400 GQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQP---------------- 448
            .:.....|.|.|..|  |..|:..|                  .:..||
  Rat   366 DRRMETTDRQWKLAH--PSSGKEIG------------------NVGYQPEGHLDCRWLCSDDRAG 410

  Fly   449 -PAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHP 512
             |:|.|.:.|.||..::              .:.:.||..:                     |||
  Rat   411 RPSGAPGRHQFSLSSTD--------------VHFLKSYHGS---------------------QHP 440

  Fly   513 K------PQFSSGLHKSAKLPVITPAGATVQP------------TW-HSVAERINDFERSQLGEP 558
            :      |:|.|   ...:|..|||:|...:|            .| .||.::::|..||.....
  Rat   441 QPCSDESPRFPS---SPRELLRITPSGCLQEPPELSQDDNPAQVRWPGSVNQKLDDRGRSHYFSV 502

  Fly   559 PKFAYLEP------------------TKTHRLSNPALKALQKNAVQSYVERQQQQQKEEQQLLRP 605
            |   :.:|                  |....|..|.|:..|:...|.|.|.....::...|.|..
  Rat   503 P---HRQPVHGSAHVLIPRSDYWHSDTTPVDLECPLLRPDQRGYPQQYEETPASHERGGYQQLNA 564

  Fly   606 HSQSY--------QACHVERKSL--PNN---------------LSPIMVGLPTGS--NSASTRDC 643
            ..:..        :|.|..|..|  |.|               .:|::..|....  ...:::||
  Rat   565 GIEGCCSGIHEPPRASHTVRAGLQCPGNDFKLVDAESGRISRQRTPMLHSLTQDGAWRPGNSKDC 629

  Fly   644 SSPTPP-------PPPRRSGSLLPNL-----LRRSSSASDYAEFRELHQAQGQVKGPSIRNISNA 696
            .:..||       .|.|||......|     :||:          :|.:::..|   ::...|.|
  Rat   630 GNEKPPLLDAQVGKPTRRSDRFATTLRNEIQMRRA----------KLQKSKSTV---TLAGDSEA 681

  Fly   697 EKISFN---DCGMPPP---PPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQH 755
            |..:.:   |.|..|.   |...:..|.....|...||.:                       |.
  Rat   682 EDCAGDWRVDVGAVPEGSFPSTYKEHLKEAQTRVLKATSF-----------------------QR 723

  Fly   756 RHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRN 820
            |...|               .|:.:.|.||:                               .|.
  Rat   724 RDLDP---------------TPADQYPGPPE-------------------------------HRT 742

  Fly   821 CFAGASTRRTTYEAPPPTAIVAAKVPPL----VPKKPTSLQH-KHLANGGGGSR-----KRPHHA 875
            |...||:..:::...|.:|      |.|    :.|.|:|... .|:...||..|     |...::
  Rat   743 CDHSASSSLSSFPGEPDSA------PRLCEAGLAKPPSSAGGVPHILRIGGRKRFTAEQKLKSYS 801

  Fly   876 TPQPILENVASPVAPPPPLLPRARSTAHDNV---------IASNLESNQQKRSNSKA-SYLPRQS 930
            .|:.|.|...|....|.|.:    .|:.|:|         .....:|..||..:.:| ..:||:.
  Rat   802 EPEKINEVGLSGDHSPHPTI----RTSEDSVGTFADRWKFFEETSKSLLQKPGHRQAFCGIPREK 862

  Fly   931 LEK-------LNNTDP-----------------DHGIYKLTLTSNEDLVAHTKPSYGVTGKLP-- 969
            .|:       ..:|:|                 |..:.|.:...|......|...|..:.|..
  Rat   863 AERPQTQGHECESTEPWFQKRSRATSCGEILSEDRKVEKASEKLNPPRRLGTFAEYQASWKEQKK 927

  Fly   970 ----------NNLPDVLPLGVKLHQQPKL----QPGSPNGDANVTLRYGSNNNLTGNSPTVAPPP 1020
                      ::..|:|..|:...|:|:.    ...||:.|     .|.....:..|.....
  Rat   928 SLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTD-----HYSQEVPVEPNRQAED--- 984

  Fly  1021 YYGGGQRYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETT 1085
              .|||:.:.....|.....|.| :....:.:|..|.:|.:  ..||..|....|......|:|:
  Rat   985 --SGGQKEALLCTLQAEEGCSAP-SSSVLSSAQPQDSQHVN--EDPTSPQPEAQLSSKCQHLQTS 1044

  Fly  1086 LEEVLPTATPTPTPTP---TPTPPRLSPASSHSDCSLSTSSLECTINPIATPIPKPEAHIFRAEV 1147
            ..|.  :.:|:|...|   |..||.|    .|.|.|                     |.|.|...
  Rat  1045 TMET--SRSPSPQFAPQKLTDKPPLL----IHEDNS---------------------ARIERVMD 1082

  Fly  1148 ISTTLNTNPLTTPPKPAMNRQES------------LRENIEKITQLQSVLMSAHLCDASLLGGYT 1200
            .:||:...|:......:...:||            |...:|| .|::: |.::..| .|....||
  Rat  1083 NNTTVKMVPIKIVHSESQPEKESRQSLACPAELPALPSGLEK-DQIKT-LSTSEQC-YSRFCVYT 1144

  Fly  1201 TPLITSPTASFANEPLMTPPLPPSP--------PPPLEPEEEEEQEENDVHDKQPEIEELQLMQR 1257
            ...:.:|..:...||  .||..|:|        ||.|...:.:|:..:|:  |..|:....:.:.
  Rat  1145 RQEVETPHRARPPEP--QPPSTPAPPVRDSCSSPPSLNYGKAKEKTVDDL--KSEELAREIVGKD 1205

  Fly  1258 SELVLMVNP--KPSTTDMACQTDELEDRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELV 1320
            ..|..:::|  |..||     .|.:|......|...||.|.|..|.|:
  Rat  1206 KSLADILDPSVKIKTT-----MDLMEGIFPKDEYLLEEAQQRRKLLPK----------------- 1248

  Fly  1321 KLLPPGDKIADILTPKICKPTSQYVSNLYNPDVP--LRLAKRDVGTSTLMRMKSITSSAEIRVVS 1383
                       :.:|::.:...|      :|.:|  :.||......||      ....||:.:..
  Rat  1249 -----------VPSPRVTEDKKQ------DPGMPGVVSLATNSTYYST------SAPKAELLIKM 1290

  Fly  1384 VELQLAEPSE----EPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAE 1444
            .:||  ||.|    :..:.:..|..|||..:::|:..|:..::::.|:..||:.||.::.|.:.:
  Rat  1291 KDLQ--EPEEYSAGDLDHDLSIKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKD 1353

  Fly  1445 KVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQQ-----ERGALESKRDLLYEQME 1504
            ..:|:|..|||..:..:..:.:||||||.|||:.|::|.....     :|.:|..|:.:|.:|.|
  Rat  1354 VCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSPSPGDRQSLLEKQRVLTQQHE 1418

  Fly  1505 EAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSD 1569
            :|:.||.:::||...:..:||..||.:..|||::|:.||:.||.:.|:|..:|...||||..|.|
  Rat  1419 DAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFD 1483

  Fly  1570 AL 1571
            :|
  Rat  1484 SL 1485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1571	CDD:462561	75/263 (29%)
Shroom2	NP_001041358.2	PDZ_shroom2_3_4-like	25..106	CDD:467232	12/39 (31%)
		ASD1	665..843	CDD:462562	45/259 (17%)
		ASD2	1196..1485	CDD:462561	90/335 (27%)