DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shrm and Shroom4

DIOPT Version :9

Sequence 1:	NP_001097307.1	Gene:	Shrm / 36592	FlyBaseID:	FBgn0085408	Length:	1576	Species:	Drosophila melanogaster
Sequence 2:	NP_001178659.1	Gene:	Shroom4 / 317391	RGDID:	1563434	Length:	1487	Species:	Rattus norvegicus

Alignment Length:	1644	Identity:	331/1644 - (20%)
Similarity:	571/1644 - (34%)	Gaps:	465/1644 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 TAFHHQKQPSYAQSEGYHSYVSSSD-STSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVA 178
            |..|.   ||.|.|..:||..::|| |....|.              |.|.|....||:.|....
  Rat   115 TTMHF---PSEAFSLSWHSGCNTSDVSVQWCPL--------------SRHCSTEKSSSIGSMESL 162

  Fly   179 PSP---------IPLLARQSHSHSHSHAHSHSNSHGHSHGHAHSASSSSSSNNNSNGSATNNNNN 234
            ..|         :|:               ..|.:......|:| |.|:|||.:....:......
  Rat   163 EQPGQATYEGHLLPI---------------EQNMYPSQRDSAYS-SFSASSNASDCALSLKPEEP 211

  Fly   235 NSSESTSS----TETLKWLGSMSDISEASHAT--GYSAISESVSSSQRIVHSSRVPTPKRHHSES 293
            .|::...|    |:......::|:.|.:||:|  |:...:...||.          :.:.|||..
  Rat   212 PSTDCVMSGPGPTKVTDDQANVSETSGSSHSTSGGHMTSTSHASSC----------SEEGHHSGP 266

  Fly   294 VLYLHNNEEQGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHRHSPS----YPPVHTSMVLH 354
            ...:....|    .|...:|.|...::..|||:...|.....:|.:..|:    .||..::....
  Rat   267 AKMVRGPPE----PPVRRDSLQASRAQLLNGEQHRASEPVDSLQQKEKPALETMLPPRSSNQFCC 327

  Fly   355 HFQQQQQQQQDYQHPSRHHTNQST------LSTQSSLLELASPTEKPRSLMGQSHSMGDLQQKNP 413
            ...|.|...:|:|:......::|:      |..:.|...|.||....:   |.:...|.|::.:.
  Rat   328 ISGQDQVTGEDHQNCELSKPSESSQDDCDHLLIEGSSKALDSPKAHDK---GSNKEFGLLKEASA 389

  Fly   414 HQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSP 478
            .....|...|....:.||....|:.|.::....|         |:.|.       |..|.|.:.|
  Rat   390 DLANTLSFGAIPHLRGSIEHRHSAPEQLLASHLQ---------QMHLD-------SRGNKGMELP 438

  Fly   479 TNSIDSYRSNHRLFPVSTYT-EPVHSNTSQYVQHPKPQFSSGLHKSAKLPVITPAGAT------- 535
            |.     :..|:      :| .|:|:|       ||.:.|.||          |.|.|
  Rat   439 TG-----QDGHQ------WTMSPLHNN-------PKGKKSPGL----------PTGGTQDQTSKE 475

  Fly   536 --VQPTWHSVAERINDFERSQL-----GEPPKFAYLEPTKTHRLS------------NPALKA-- 579
              ::||...:....|..:...|     |.|.:..||:..:..|.|            :|..:.
  Rat   476 RKIKPTDDKLMVSANQSQSDALLGEVDGHPSERTYLDSNRASRASSDLTGQQPSATCSPVQQTRD 540

  Fly   580 -LQKNAVQSYVERQQQQQKEEQQLLR--------PHSQSYQACHVERKS---------------- 619
             ...|.|..:.|..::...|.::..|        |..:|.|.   .|||
  Rat   541 FFSANKVVGHTEATEEGDNEPKEGGRLGGRRSGGPRGRSIQN---RRKSERFATNLRNEIQRRKA 602

  Fly   620 -LPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPPRRSGSLLPNLLRRSSSASDYAEFRELHQAQG 683
             |..:..|:.....|..:...|::  .|..||.|..:.||||: .:...|..|     :|.....
  Rat   603 QLQKSKGPLSQLCDTKEDVEETQE--PPESPPLPASNSSLLPS-YKNVPSHGD-----QLFNKSM 659

  Fly   684 QVKGPSIRNISNAEKISFNDCGMPPPPPPPRGRLAVPTRRTSSAT----EYAPMRDKLLLQQAAA 744
            .::..|...:|.|.:.|....|:       .||:: |.:|:..::    .:....|...|....|
  Rat   660 ILRARSSECLSQASESSKARVGL-------EGRMS-PGQRSGQSSLALNTWWKASDSSTLDTEKA 716

  Fly   745 LAH----QQHHPQQHRHAQPPHVP-----PERPPKHPNLRVPSPELPPPPQSELDISYTFDEPLP 800
            .||    :.|......|...|.|.     |..|..:..|::|:|:             ..||
  Rat   717 NAHHGVCRGHWRWSPEHNAQPQVALSTEGPSNPDDNKELKIPTPQ-------------AGDE--- 765

  Fly   801 PPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPKKP-----TSLQHK- 859
                 .:|.    |..:||..|..:|...:|...|   .:.....|.:...||     .|:.::
  Rat   766 -----AILM----PFADRRKFFEESSKSLSTSHLP---GLTTHNKPFIQRPKPIDQNFQSVSYRE 818

  Fly   860 ---HLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSNS 921
               |..:....|..:|:||..|..  :..||:....|..|..
  Rat   819 LRCHPMDQSYHSADQPYHAADQSY--HSLSPLQSEAPTYPDC----------------------- 858

  Fly   922 KASYLPRQSLEKLNNTDPDHG--IYKLTLT---SNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVK 981
               :.|:.....|......||  .|..|.:   |.:..|.| .|....:|       ::.|..:|
  Rat   859 ---FAPKGVDNSLYCKPVHHGDCDYHRTCSHPCSAQGTVMH-DPCICCSG-------EICPALLK 912

  Fly   982 LHQQPKLQPGSPNGDANVTLRYGSNNNLTG--NSPTVAPPPYYGGGQRYSTPVLGQGYGKSS--- 1041
            .:..||..        |....:......||  :||       ..|....|:...|..: ||.
  Rat   913 RNLLPKCH--------NCRCHHHQCIRCTGCCHSP-------QHGAHEDSSMASGNAW-KSRKAA 961

  Fly  1042 ---------KPVTPQQYTRSQSYDVKHT------SAVTMPTMSQSHVDLK--QAAHDLETTLEEV 1089
                     ||:|..:.|.....::.|:      ||...|.:..|.:||.  :|...|:  |...
  Rat   962 IQEFPVDKWKPITGNRKTSHSGREMAHSKANLSLSAPFRPHIENSALDLSNYRAVSSLD--LLGD 1024

  Fly  1090 LPTATPTPTPTPTPTPPRLSPASSHSDCSLSTSSLECTINPIATPIPKPEAHIFRAEVISTT-LN 1153
            ...|:.||           ..:|.:.|.| |.:|:           |:|    .|:...|.: ::
  Rat  1025 FKHASNTP-----------EESSVYEDES-SVASM-----------PRP----LRSRAFSESHIS 1062

  Fly  1154 TNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMT 1218
            ..|..|   .|..:|:  ||:..|.::                        |.|....|.:....
  Rat  1063 LEPQNT---RAWGKQQ--RESFSKGSE------------------------TQPDTLGARKKAFP 1098

  Fly  1219 PPLPPSPPPPLE-------PEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQ 1276
            ||.|  |||..|       .:::::|::.....:|.:.::                       |:
  Rat  1099 PPRP--PPPNWEKYRLFRAAQQQQQQQQQQQQQQQQQQQQ-----------------------CE 1138

  Fly  1277 TDELEDRDTDLEAAREE------HQTRTT-----LQPRQRQPIELDYEQMSRELVKLLP------ 1324
            .:|.|:::.:.:..:||      ..:.||     :...|.|.:::.:::.||:..:.|.
  Rat  1139 KEEEEEKEQEEKGEKEEDLPPQYFSSETTGSCAPITEEQPQSLKMGHQEASRQSSQSLQEQEAYA 1203

  Fly  1325 -------PGDKIADILTPKICKPTSQYVSN----------LYNPDVPLRLAKRDVGTSTLMRMKS 1372
                   |..:...:..|:..:|...|.::          ...|....:......|.|.:  ..|
  Rat  1204 VHPSNFVPAVRSYPVTQPEKAQPPCYYGAHGLWRTTEQEATVTPKQEFQHFSPPTGASGI--PTS 1266

  Fly  1373 ITSSAEIRVVSVEL--------QLAEP--SEEPTNL-IKQKMDELIKHLNQKIVSLKREQQTISE 1426
            .::...|.|...||        ::||.  .||..:. :.||..:||:.:::|:..|:..|:.:.:
  Rat  1267 YSAYYNISVAKAELLNKLKQQPEMAEAGLGEEGVDYELAQKKIQLIESISRKLSVLREAQRGLLD 1331

  Fly  1427 ECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLET----RQQ 1487
            :.:||..||:::...|....:.:|..|:...:..:..:.:||||||.|||:.|::|.:    ..|
  Rat  1332 DINANAALGEEVEVNLKAVCKSNELEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDAESNQ 1396

  Fly  1488 ERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARD 1552
            |:..|..|:..|..|:.:|:.||..::||...:..::::.|..|...||.:|:.||:.||.:.|:
  Rat  1397 EKLVLREKKQQLTNQLADAKELKEHVDRREKLVFSMVSRYLPQDQLQDYQHFVKMKSALIIEQRE 1461

  Fly  1553 LAVRIKGSEEQLSSLSDAL 1571
            |..:||..||||..|.::|
  Rat  1462 LEEKIKLGEEQLKCLKESL 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	71/289 (25%)
Shroom4	NP_001178659.1	PDZ_signaling	13..89	CDD:238492
Shroom4	NP_001178659.1	ASD2	1241..1479	CDD:285850	66/239 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351043
Domainoid	1	1.000	108	1.000	Domainoid score	I6290
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45270
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15012
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.030