Protein Alignment Shrm and Shroom3

DIOPT Version :10

• Sequence 1: NP_001097307.1
• Gene: Shrm / 36592
• FlyBaseID: FBgn0085408
• Length: 1576
• Species: Drosophila melanogaster
• Sequence 2: XP_006250785.1
• Gene: Shroom3 / 305230
• RGDID: 1310470
• Length: 1987
• Species: Rattus norvegicus
• Alignment Length: 1906
• Identity: 399/1906 - (20%)
• Similarity: 646/1906 - (33%)
• Gaps: 560/1906 - (29%)

  Fly    75 HHNSSSSQLGQQHGSSL----DQCGLTQAGLEEYNNR-------------SSSYYDQTAFHHQKQ 122
            |.:||:|.|.....:.|    |:|. :|..:|....|             |:|..||....|.|:
  Rat   193 HSSSSTSDLSNYDHAYLRRSPDRCS-SQGSMESLGPRGGSPPCHLLSPAKSTSSIDQLGHLHNKR 256

  Fly   123 PSYAQSEGYHSYVSSSDSTSATP--------------------FLDKLRQESDLLSRQSHHWSEN 167
            .|     .|.|:.:||......|                    .|:.:|| :|:...::.:.:..
  Rat   257 DS-----AYSSFSTSSSIFEYPPPGGSARERSGSLDMIPARGGLLEGMRQ-ADIRYVKTVYDTRR 315

  Fly   168 DLSSVCSNSVAPSPIPLLARQSHSHSHSH--AHSHSNSHGH-----------------SHGHAHS 213
            .:||  ...|.||.:.|..|.:|:.:.|.  |..||...|.                 :....|.
  Rat   316 GVSS--EYEVNPSALLLQGRDAHTSADSQGCAKWHSIPRGKGTPPLPWSQQCSGSPETADNPPHK 378

  Fly   214 ASSSSSSNNNSNGSATNNNNNNSSESTSSTETL-----KWLGSMSD--ISEASHATGYSAISESV 271
            |.:......:.:..|..:....||.|:...:..     ..|||...  :.|..|.....:...|.
  Rat   379 AGAPMPPTRSDSYVALRHRERPSSWSSLDQKRFCRPQTNSLGSQKTPFVEEQLHTVPERSPENSP 443

  Fly   272 SSSQRIVHSSR--------------VPTPKRHHSE---------SVLYLHNNEEQGDSSPTASNS 313
            ....:..::.:              ||:|:.|.::         ..:|....:|.|.::...:.|
  Rat   444 PVKPKHNYTQKTQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSGNGTVYPALVKESGYTAAQGTCS 508

  Fly   314 SQMMISEEANGEE---------SPP---SVQPLRIQHRHSPSYPP--VHTSMVLHHFQQQQQQQQ 364
            ....:.|..|.:|         .||   |:.|:..:......|.|  ||.|.|     .:.:...
  Rat   509 KMAALDENGNQKEVSRPGFAFCQPPEHDSMTPVEKKPEPRAKYIPYKVHFSSV-----PENEDSS 568

  Fly   365 DYQHPSRHHTNQSTLSTQSSLLELASPTEKPRSLMGQS------HSMGDLQQKNPHQ-------- 415
            ..:|.:..|.|        ||.    |:|:.....|.|      ||:...|.:.||.
  Rat   569 LKRHVTPPHGN--------SLY----PSERKNVHGGGSRPCSNHHSLPSAQAQAPHAGDDDRRPS 621

  Fly   416 ---NPMLGRSAGQQHKSSISVTI-----------SSSEAVVTIAPQPPAGKPSKLQLSLGKSEAL 466
               .|..| ...:.|.:::...:           :|.....|.:|.....:..:.|.|:...|.|
  Rat   622 RLFQPWEG-DFQEDHNANLRQKVEREGQGQGLPGNSGGTKSTFSPLQNIPENLRRQSSVDLGEGL 685

  Fly   467 --------SCSTPNMGEQSPTNSIDSYRSNHRLFPVSTYTEPVHSNTSQYVQHPKPQFSSGLHKS 523
                    :|:|.....:.|..........:               ..:.|.:|:|:   |...:
  Rat   686 EVYPGGRSTCATTTTKVEDPGRKAGPDNRGY---------------LDRSVSYPRPE---GKMNA 732

  Fly   524 AKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKFAYLEPTKTHRLSNPALKALQ-KNAVQS 587
            |:             ::||...|..:    .|..||:  ........|||..:..||| |....|
  Rat   733 AE-------------SFHSADSRYEE----PLAAPPQ--QTSGMSQRRLSASSTPALQYKKPHCS 778

  Fly   588 YVERQQQQQKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPP 652
            .:|:..:.::.||...||.|....|..:..:       |...| ||.|.|:|..|        .|
  Rat   779 VLEKVSKIEEREQGRHRPTSVGSSAYALSYR-------PGRTG-PTPSTSSSDLD--------DP 827

  Fly   653 RRSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDC----------GMP 707
            :.|.|      ..|.||:::....|.:...|:.|         .|:.|...|          |..
  Rat   828 KASSS------HFSESAAEHLRNGEQNPPNGEPK---------LEEASRQQCNQLLRRTTADGRG 877

  Fly   708 PP-----PPPPRGRLA---------VPTRRTSSATEYAP---------------MRDKLLLQQAA 743
            ||     |..|..||.         ....|.:|.:|..|               .|:.:...|:.
  Rat   878 PPARGSEPSRPEARLLRSQSTFQLFSEAEREASWSEDRPSTPESPLLDAPFSRAYRNSIKDAQSR 942

  Fly   744 ALAHQQHHPQQHRHAQPPHVPPERP-PKHPNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEV 807
            .|.......:......|....|.|| |...::.:.|||...|..|             |..|.|.
  Rat   943 VLGATSFRRRDLEPGTPATSRPWRPRPASAHVGMRSPEASAPLSS-------------PHTPRER 994

  Fly   808 LQPRP----PPSPN--RRNCFAGASTRRT------TYEAPPPTAIVA----AKVPPLVPKKPTSL 856
            ....|    ||:|.  ||    ||..|.|      :|..|.....|.    |:....||::|..|
  Rat   995 HSVTPATGTPPAPQAARR----GARRRLTAEQKKRSYSEPEKMNEVGVSEEAESVHCVPQRPAQL 1055

  Fly   857 Q--------HKHLANGGG---------------------------GSRKRPHHA--TPQPILENV 884
            :        .:.|....|                           .:.|||..|  ||:|.|...
  Rat  1056 RFSESTVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTGAACTPEPGLRER 1120

  Fly   885 AS-------PVAPPPPLLPRARSTA------------HDNVIASNLESNQQKRSNSKAS------ 924
            |.       |.||..|.|..|.|.:            |.:..|::.....:.||:|.||
  Rat  1121 AQSVYFQAVPAAPEGPGLASACSLSSLREPEVLPCKEHPHQSAADGPQTPRDRSSSFASGRLVGE 1185

  Fly   925 ------YLPRQSLEKLNNTDPDHGIYKLTLTS----NEDLVAHTKPSYGVTGKLPNNLPDVL--- 976
                  ..|||.|... |..| .|:.::..||    :.|:|.      |.:|| ..:..|:|
  Rat  1186 RRRWDPQAPRQLLSGA-NCGP-RGVQRMDRTSRGPPSWDMVV------GKSGK-SKSAEDLLERS 1241

  Fly   977 -PLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTGN----SPTVAPPPYYGGGQRYSTPVL--- 1033
             .|.|.:|.:.:..|.|.....:|.||..|......:    .|...|..|...||:.....|
  Rat  1242 DTLTVPVHVRSRSSPTSDKKGQDVLLREDSGFGFVKDPYLAGPGSRPLSYSDRGQKEQALPLHHP 1306

  Fly  1034 -----GQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPTA 1093
                 |.||  .:..|:..:.:.:..:..:..:....|..:..|      .|..:.....|.|.:
  Rat  1307 ATCWNGSGY--KATVVSSTESSGAPDHLKQLRAPCPRPLSAGMH------GHFPDARASSVAPLS 1363

  Fly  1094 TPTPTPTPT---------------PTPPRLSPAS---------SHSDCSLSTSSLECTINPIATP 1134
            :|.|:|.|:               |.|   ||||         ||   .|.....:....|...|
  Rat  1364 SPLPSPVPSGYRSQLDMDQQMGHQPLP---SPASAVTQPPSPRSH---ELEEGMWKRASLPQRPP 1422

  Fly  1135 IPKPEAHIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASL---- 1195
            .|...||..|.:.::...::.|.....|...| |.||..:...........:|..:.:::|
  Rat  1423 RPWKWAHAVREDGLAEDASSAPEFATLKHYKN-QLSLPSSCSTSDPDTPGRISLRISESALQASP 1486

  Fly  1196 --LGGYTTPLI---------TSPTASFANEPLMTPPLP-------------PSPPP------PLE 1230
              .|.|...:.         :|||.. |..|...||.|             |||||      ||:
  Rat  1487 PPRGDYDDEVFVKDLHPKVPSSPTFE-ALPPPPPPPSPLSQEPLTCGSDDFPSPPPQAMCEAPLD 1550

  Fly  1231 PEEEEEQEEND-------VHDKQPEIEELQLMQRSELVLMVNPKPSTTDMACQ------------ 1276
            .|..||.....       ...::.::......:.|::::.:.|:.|....|.:
  Rat  1551 GEVSEEPGSGSSCGLPRVTATREGQVPGAGHAEGSQIMVAIPPQTSAEGSAAESSTAARVSAQPP 1615

  Fly  1277 -----------------TDELEDRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELVKLLP 1324
                             |.|..||..||  .::.|     .:| |:...::..|.:::|:|.
  Rat  1616 LHSFPGKQPCPSQARNLTYEPADRTQDL--GKKIH-----AEP-QKTSEDIRTEALAKEIVH--- 1669

  Fly  1325 PGDK-IADILTP-KICKPTSQYVSNLYNPDVPL--------------RLAKRDVGTSTLMRMKSI 1373
             .|| :||||.| ...|.|...:..|:..|..:              |.|..:|.||.......:
  Rat  1670 -QDKSLADILDPDSRMKTTMDLMEGLFPRDAGVLKENAERRAVDSTTRRAGWEVETSDHKEAAGV 1733

  Fly  1374 -----------TSSAEI--RVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTIS 1425
                       .:.||:  ::..:..:|.|  ||....:.:|..|||..|..|:.:|:..:.::.
  Rat  1734 LVNCPAYYSVSAAKAELLNKIKDMPEELRE--EEEQEDVNEKKAELIGSLTHKLETLQEAKGSLL 1796

  Fly  1426 EECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETR 1485
            .:...|:.||:::.|.::|..:|:|..|::..:..:..:.:||||||.|||:.|:.|     :..
  Rat  1797 TDIRLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDAS 1861

  Fly  1486 QQERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADA 1550
            ::||.:|..||.:|..|.|:|:.||.:::||...:..:||..|||:...||.:|:.||:.|:.:.
  Rat  1862 KEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILANYLSAEQLQDYQHFVKMKSTLLIEQ 1926

  Fly  1551 RDLAVRIKGSEEQLSSLSDAL 1571
            |.|..:||..:||:..|.::|
  Rat  1927 RKLDDKIKLGQEQVRCLLESL 1947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1571	CDD:462561	81/286 (28%)
Shroom3	XP_006250785.1	PDZ_shroom2_3_4-like	26..107	CDD:467232
		PTZ00449	<746..1005	CDD:185628	66/304 (22%)
		ASD1	891..1074	CDD:462562	41/199 (21%)
		ASD2	1662..1947	CDD:462561	81/290 (28%)