DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shrm and Shroom1

DIOPT Version :9

Sequence 1:	NP_001097307.1	Gene:	Shrm / 36592	FlyBaseID:	FBgn0085408	Length:	1576	Species:	Drosophila melanogaster
Sequence 2:	XP_006246429.1	Gene:	Shroom1 / 287285	RGDID:	1308066	Length:	858	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	211/978 - (21%)
Similarity:	321/978 - (32%)	Gaps:	288/978 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   707 PPPPPPPRGRLAVPT------------RRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQ 759
            ||.||.|     ||.            .|||.|::...: |...|...|..|:...
  Rat    20 PPGPPTP-----VPNCTTMETTMGTGRDRTSQASDTESL-DLRRLSTRADSAYSSF--------- 69

  Fly   760 PPHVPPERPPKHPNLRVPSPELPPPPQSELD-----------ISYTFDEPLPPPPPPEVL----Q 809
                  ......|..|.|||.....|..:.|           ||......:...|.|.|:    .
  Rat    70 ------STASGGPETRTPSPGTERLPYLDWDYVRVVWGNRSPISKDAVPSMTQGPGPAVVAGHSD 128

  Fly   810 PRPP-----PSPNRR---------NCFAGASTRRTTYEAPPPTAIVAAKVPPLVPK-----KPTS 855
            ||||     ..|..|         ...|.|:||  |.|.|.|.|..||....|...     :.||
  Rat   129 PRPPEVQGNAGPLSRQDTPLLYALTAEAEATTR--TAEPPSPPASRAAYRQRLQGAQRRVLRETS 191

  Fly   856 LQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASNLESNQQKRSN 920
            .|.|.|.....| |.||            |.|..||         |.|....:|:.|..:.:.:
  Rat   192 FQRKELRMSLPG-RLRP------------ALPARPP---------TGHVRSASSSQELGEAEPA- 233

  Fly   921 SKASYLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVKLHQQ 985
                   |.::..|......|      |.|.:.|...::|.                   |||
  Rat   234 -------RAAVPALGAAGRGH------LASQQRLCCFSEPG-------------------KLH-- 264

  Fly   986 PKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQYT 1050
                            |.|.:...||.          |..:.|||..|.:|....||.:   |.|
  Rat   265 ----------------RVGWSGGPTGE----------GLREAYSTQELQRGMHAKSKGL---QET 300

  Fly  1051 RS-QSYDVKHTSAVTMPTMSQSHVDLKQAAHDLE----TTLEEVLPTATPTPTPTPTPTPP---R 1107
            :| .|.::...||    .::.:|   :.|.....    |..|..:.|....|....||.||   :
  Rat   301 QSLSSTELNSRSA----NLASAH---RPAGRSQSVSGCTGSERTVATVQVVPQRADTPRPPLQTK 358

  Fly  1108 LSPASSHSDC-------SLSTSSLECT-INP---IATPIPK-PEAHIFRAEVISTTLNTN----- 1155
            ||...:..:.       :|......|. .||   ::||.|. |:..:|..|..:.:...:
  Rat   359 LSRFLTQKEAAVVCPGEALQAKPAGCARRNPETTVSTPGPSLPDDEVFLKEAKTASPQDSHAPHG 423

  Fly  1156 -PLTTPPKPAMNRQESLRENIEKIT-----QLQSV--LMSAHLCDASLLGGYTTPLITSPTASFA 1212
             |.:|..:|:.|   .|.:...:||     .|..|  :..|..|...:.|...   |:.||:.
  Rat   424 LPTSTSDRPSEN---GLSKKAGQITVSAERALHEVPGIAGADNCWQGVNGSVH---ISRPTSR-- 480

  Fly  1213 NEPLMTPPLPPSPPPPLEPEEEEEQEENDVHDKQPEIEELQLMQRSELVLMVNP-KPSTTDMACQ 1276
                .||.......|..        :.|...|.....|:             || ||.:.|:...
  Rat   481 ----STPETTNDDTPTF--------DTNGTTDPSAATEK-------------NPLKPPSVDVLTT 520

  Fly  1277 TDELEDRDTDLEAAREEHQTRTTLQPRQRQPI--ELDYEQMSRELVKLLP-PGDKIADILTPKIC 1338
            :|.        |.....|....|......:|.  ...:|::.:||.:|.| ..|.:|....|
  Rat   521 SDS--------ETPGSPHHASLTWGQLGSKPTWPSRHFEELVQELARLDPFLSDTLAAQPGP--- 574

  Fly  1339 KPTSQYVSNLYNPDVPLRLAKR-------------DVGTSTLMRMKSITSSAEIRVVSVELQLAE 1390
            :|....:..|: |...:|.|.|             :.|:......:.:.:|.|          |.
  Rat   575 EPPLGLLDGLF-PAEEIRSAMRPAREEAGEKAGASEEGSCGCHFTQELPTSQE----------AS 628

  Fly  1391 PSEEPT----------------NLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLF 1439
            .||..|                |..:.|..||.:.|.:.:..|..||:.:..:.:...|....|.
  Rat   629 RSENSTPDPVPDQSSGQGFPEGNSTQAKKVELARLLQKMLQDLHAEQERLRGKAADWTRHNGALE 693

  Fly  1440 AKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQERGALESKRDLL 1499
            |.:::...|.|..:||..:..:..:..|||.|..||.:...:|     ::...||.:|..:..||
  Rat   694 AAVSQACTPRELERFRRFMTDLERVLGLLLLLGSRLTRVNLALARAGSDSDPDERASLLQRLLLL 758

  Fly  1500 YEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQL 1564
            ..|.|:|:.||..:.||..::..:|.:.|.|:....|...:..||::::..|.|..||:..:|||
  Rat   759 QRQQEDAKELKEHVARREQTLRQVLERELPAEHLRSYCVLLAAKARILSQQRSLDDRIRFLKEQL 823

  Fly  1565 SSL 1567
            .::
  Rat   824 DTI 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	67/285 (24%)
Shroom1	XP_006246429.1	ASD1	150..273	CDD:285851	41/197 (21%)
Shroom1	XP_006246429.1	ASD2	552..829	CDD:285850	67/289 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15012
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030