DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shrm and Shroom3

DIOPT Version :10

Sequence 1:NP_001097307.1 Gene:Shrm / 36592 FlyBaseID:FBgn0085408 Length:1576 Species:Drosophila melanogaster
Sequence 2:NP_056571.2 Gene:Shroom3 / 27428 MGIID:1351655 Length:1980 Species:Mus musculus


Alignment Length:1847 Identity:403/1847 - (21%)
Similarity:642/1847 - (34%) Gaps:540/1847 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 VSVSKLLLKDSNGANSRSSNSNASFSSASVAGSVQDDLPH-HNSSSSQLGQQHGSSLDQC--GLT 97
            |:.|.|||:..:...|..|...|.:.|          :|. ..:.|....||...||:..  .|.
Mouse   323 VNPSALLLQGRDAHASADSQGCAKWHS----------IPRGKGTPSPSWSQQCSGSLETATDNLP 377

  Fly    98 Q-AGLEEYNNRSSSYYDQTAFHHQKQPSYAQSEGYHSYV---SSSDSTSATPFL-DKLR------ 151
            | ||......||.||   .||.|:::||...|.....:.   ::|..:..|||. |:|.      
Mouse   378 QKAGAPLPPTRSDSY---AAFRHRERPSSWSSLDQKRFCRPQTNSSGSQKTPFAEDQLHTVPERS 439

  Fly   152 QESDLLSRQSHHWSENDL--SSVCSNSVAPSPIPLLARQSHSHSHSHAHSHSNSHGHSHGHAHSA 214
            .|:....:..|::::...  ..:....:.|.|.|      ..|.........:|:|..:......
Mouse   440 PENSPPVKSKHNYTQKAQPGQPLLPTGIYPVPSP------EPHFAQVPQPSVSSNGTVYPALVKE 498

  Fly   215 SSSSSSNNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHATGYSAISESVSSSQRIVH 279
            |..:::....|..||.:.|.|.:|::                    ..|:       :..|.:.|
Mouse   499 SGYTAAQGTCNKMATLDENGNQNEAS--------------------RPGF-------AFCQPLEH 536

  Fly   280 SSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQMMISEEANGEES-------PPSVQPLRIQ 337
            :|..|..||                 ..|||....::..|.....|:|       ||        
Mouse   537 NSVTPVEKR-----------------PEPTAKYIYKVHFSSVPENEDSSLKRHITPP-------- 576

  Fly   338 HRHSPSYPP----VH---TSMVLHHFQQQQQQQQ----DYQHPSR------------HHTN---- 375
            |.||| ||.    :|   .:...||.....|.|.    |.:.|||            |:.|    
Mouse   577 HGHSP-YPSERKNIHGGSRACSNHHSLSSPQAQALHVGDDRRPSRLSQPWEGDFQEDHNANLRQK 640

  Fly   376 --------------QSTLSTQSSLLELASPTEKPRSLMGQSH-SMGDLQQKNPH-----QNPMLG 420
                          ..|.|..|||..:      |.||..||: .:|:.|:.:|.     ::|  |
Mouse   641 VEREGQGQGLSGNSGRTRSAFSSLQNI------PESLRRQSNVELGEAQEVHPGGRSKVEDP--G 697

  Fly   421 RSAGQQHKSSISVTISSSEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSY 485
            |.||   .|.|...:..|     ::...|.||                          .|::|| 
Mouse   698 RKAG---ASDIRGYLDRS-----VSYPRPEGK--------------------------MNAVDS- 727

  Fly   486 RSNHRLFPVSTYTEPVHSNTSQYVQHPKPQF--SSGLHKSAKLPVITPAGATVQPTWHSVAERIN 548
                           |||..|:|.:.|.|..  :||. ...:|...:.|....:....||.|:::
Mouse   728 ---------------VHSADSRYEESPAPALPQTSGA-SQRRLSSSSSAAPQYRKPHCSVLEKVS 776

  Fly   549 DFERSQLG----------------EPPKFAYLEPTKTHRLSNPALKALQKNAVQSYVERQQQQ-- 595
            ..|..:.|                .|.:......|.:..|.:|...::..:....::...:|.  
Mouse   777 RIEEREQGRHRPLSVGSSAYGPGYRPGRTGPTPSTSSSDLDDPKAGSVHFSESTEHLRNGEQNPP 841

  Fly   596 --QKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPPRRSGSL 658
              :.::::..||     |..|:.|::            |.....             ||.|.|. 
Mouse   842 NGEAKQEEASRP-----QCSHLIRRA------------PADGRG-------------PPARGGE- 875

  Fly   659 LPN-----LLRRSSSASDYAEF-RELHQAQ---GQVKGPSI-RNISNAEKISFNDC--------- 704
             |:     |||..|:...|:|. ||...::   |..:.|.: ...|.|.:.|..|.         
Mouse   876 -PSRPEARLLRSQSTFQLYSEAEREASWSEDRPGTPESPLLDAPFSRAYRNSIKDAQSRVLGATS 939

  Fly   705 --------GMPPPPPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPP 761
                    |.|....|.|.|         .|:.:..||.    .:||..:...|.|:: ||:..|
Mouse   940 FRRRDLEPGTPATSRPWRPR---------PASAHVGMRS----PEAAVPSSSPHTPRE-RHSVTP 990

  Fly   762 HVPPERPPKHPNLRVPSPE-----LPPPPQSELDISYTFDEPLPPP-PPPEVLQPRPPPS--PNR 818
             ..|:...:.|..|:...:     ..|...:|:.:|   :|..|.| .||...|||...|  .:|
Mouse   991 -AAPQAARRGPRRRLTVEQKKRSYSEPEKMNEVGVS---EEAEPTPCGPPRPAQPRFSESTVADR 1051

  Fly   819 RNCFAGASTRRTTYEAPPP------TAIVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATP 877
            |..|.......:|.....|      .:.:|..:.....|:||..    ......|.|:|...|..
Mouse  1052 RRIFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTGA----ACTPEAGLRERAQSAYL 1112

  Fly   878 QPILENVASPVAPPPPLLPRARSTA------------HDNVIASNLESNQQKRSNSKAS------ 924
            |      |.|.||..|.|..|.|.:            |.:..|::.....:.||:|.||      
Mouse  1113 Q------AGPAAPDGPGLASACSLSSLREPEALPRKEHTHPSAADGPQAPRDRSSSFASGRLVGE 1171

  Fly   925 ------YLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYG-VTGKL--PNNLPDVL---- 976
                  .:|||.|... |.:| .|:.::      |......||:| |.||.  ..:..|:|    
Mouse  1172 RRRWDPQVPRQLLSGA-NCEP-RGVQRM------DGAPGGPPSWGMVAGKAGKSKSAEDLLERSD 1228

  Fly   977 PLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKSS 1041
            .|.|.:|.:.:..|.|.....:|.||.|||.....:...:|.|     |.| |.....:|..:.:
Mouse  1229 TLAVPVHVRSRSSPTSDKKGQDVLLREGSNFGFVKDPCCLAGP-----GPR-SLSCSDKGQNELA 1287

  Fly  1042 KPV---TPQQYTRSQSYDVKHTSAVTMPTMSQSHVD-LKQ----AAHDLETTLEEVLPTA----- 1093
            .|:   ||..    .....|.|.|.:.|..|....| |||    ....|...:....|.|     
Mouse  1288 LPLHHPTPCW----NGSGCKATVASSAPPESSGAADHLKQRRAPGPRPLSAGMHGHFPDARAASL 1348

  Fly  1094 -TPTPTPTPT--------------------------PTPPRLSPASSHSDCSLSTSSLECTINPI 1131
             :|.|:|.|:                          ||.|| ||..|.....|.....:.|..|.
Mouse  1349 SSPLPSPVPSSYRSQLAMDQQTGQQPPSSPASAVTQPTSPR-SPELSSPAYGLGEGMWKRTSLPQ 1412

  Fly  1132 ATPIPKPE-AHIFRAEVIS---------------------TTLNTNPLTTPPKPAMNRQESLREN 1174
            ..|.|..: ||..|.:.::                     ::.:|:...||.:.::...||..: 
Mouse  1413 RPPPPWVKWAHAVREDGLAEDTLAPEFANLKHYRNQPSRPSSCSTSDPDTPGRISLRISESALQ- 1476

  Fly  1175 IEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPPLPPS-------------PP 1226
                   .|........|...:......:.:|||  |...|...||.|||             ||
Mouse  1477 -------PSPPPRGDYDDEVFMKDLHPKVTSSPT--FEALPPPPPPSPPSEEPLVNGTDDFPPPP 1532

  Fly  1227 PP-------LEPEEEEEQEENDVH------DKQPEIEELQLMQRSELVLMVNPKPSTTDMACQTD 1278
            ||       |:.|...|.......      .::..:......:.|:::....|:.|     .:..
Mouse  1533 PPQALCEVLLDGEASTEAGSGPCRIPRVMVTREGHVPGAAHSEGSQIMTATPPQTS-----AKGS 1592

  Fly  1279 ELEDRDTDLEAAREE-----------HQTRT-TLQPRQR----------QPIELDYEQMSRELVK 1321
            |.|.......:|:.:           .|||. |.:|.:|          :|.:...:..:..|.|
Mouse  1593 EAESNTPSSASAQPQLNGSPGKQLCPSQTRNLTYEPVERTQDLGKKTHAEPQKTSEDIRTEALAK 1657

  Fly  1322 LLPPGDK-IADILTP-KICKPTSQYVSNLYNPDVPLRL---AKR---DV---------------- 1362
            .:...|| :||||.| ...|.|...:..|:..|..:.:   |||   |:                
Mouse  1658 EIVHQDKSLADILDPDSRMKTTMDLMEGLFPGDASVLMDSGAKRKALDITARRAGCEAKASDHKE 1722

  Fly  1363 GTSTLMRMKSITSSA--------EIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKR 1419
            ..|.|:...:..|.:        :|:.:..|||..|..|:    :.:|..|||..|..|:.||:.
Mouse  1723 AVSVLVNCPAYYSVSAAKAELLNKIKDMPEELQEEEGQED----VNEKKAELIGSLTHKLESLQE 1783

  Fly  1420 EQQTISEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-- 1482
            .:.::..:...|:.||:::.|.::|..:|:|..|::..:..:..:.:||||||.|||:.|:.|  
Mouse  1784 AKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENVLRG 1848

  Fly  1483 ---ETRQQERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKA 1544
               :..::||.:|..||.:|..|.|:|:.||.:::||...:..:||..|||:...||.:|:.||:
Mouse  1849 LGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILANYLSAEQLQDYQHFVKMKS 1913

  Fly  1545 KLIADARDLAVRIKGSEEQLSSLSDAL 1571
            .|:.:.|.|..:||..:||:..|.::|
Mouse  1914 TLLIEQRKLDDKIKLGQEQVRCLLESL 1940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShrmNP_001097307.1 ASD2 1318..1571 CDD:462561 84/289 (29%)
Shroom3NP_056571.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
PDZ_shroom2_3_4-like 26..107 CDD:467232
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 152..199
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..239
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 342..463 30/133 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 564..1055 126/608 (21%)
PHA03247 <737..1134 CDD:223021 93/457 (20%)
ASD1 882..1060 CDD:462562 47/195 (24%)
PHA03247 <943..1484 CDD:223021 132/595 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1083..1102 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1107..1223 31/129 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1440..1648 37/222 (17%)
ASD2 1654..1940 CDD:462561 84/289 (29%)
Blue background indicates that the domain is not in the aligned region.

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