DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shrm and Shroom4

DIOPT Version :9

Sequence 1:	NP_001097307.1	Gene:	Shrm / 36592	FlyBaseID:	FBgn0085408	Length:	1576	Species:	Drosophila melanogaster
Sequence 2:	NP_001035549.1	Gene:	Shroom4 / 208431	MGIID:	2685570	Length:	1475	Species:	Mus musculus

Alignment Length:	1646	Identity:	325/1646 - (19%)
Similarity:	547/1646 - (33%)	Gaps:	481/1646 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 TAFHHQKQPSYAQSEGYHSYVSSSD-STSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVA 178
            |..|.   ||.|.|..:||..::|| |....|.              |.|.|....||:.|....
Mouse   115 TTMHF---PSEAFSLSWHSGCNTSDVSVQWCPL--------------SRHCSTEKSSSIGSMESL 162

  Fly   179 PSP---------IPLLARQSHSHSHSHAHSHSNSHGHSHGHAHSASSSSSSNNN----------- 223
            ..|         :|:               ..|.:......|:|:.|:||:.::
Mouse   163 EQPGQPTYEGHLLPI---------------DQNMYPSQRDSAYSSFSASSNASDCALSLKPEEPP 212

  Fly   224 --------------SNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHATGYSAISESVSSS 274
                          ::..|..:.|:.||.|||.          ..::..|||:.||
Mouse   213 STDCVMPGPGPIKVTDDQANVSENSGSSHSTSE----------DHVTSTSHASSYS--------- 258

  Fly   275 QRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQMMISEEANGEESPPSVQPLRIQHR 339
                       .:.|||..........|    .|..|:|.....::..|||:...|.....:..:
Mouse   259 -----------DEGHHSGPAKMARGPPE----PPVRSDSLPASRAQLLNGEQHRASEPVDSLPQK 308

  Fly   340 HSPS----YPPVHTSMVLHHFQQQQQQQQDYQHPSRHHTNQST------LSTQSSLLELASP--- 391
            ..|.    .||..::.......|.|...:|:|:......::|:      |..:.|...|.||
Mouse   309 EKPGLETVLPPRSSNQFCCLSGQDQVTDEDHQNCELSKPSESSQDDCEHLLIEDSSKALDSPKAH 373

  Fly   392 ---TEKPRSLMGQS--------------HSMGDLQQKNPHQNPMLGRSAGQQHKSS-----ISVT 434
               :.|...|:.::              |..|.::.::.....:|.....|.|..|     :.:.
Mouse   374 DKGSNKEFGLLKEASADLANTLNFGAIPHLRGTMEHRHSAPEQLLASHLQQVHLDSRGSKGMELP 438

  Fly   435 ISSSEAVVTIAP--QPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSYRSNHRLFPV-ST 496
            |.......|::|  ..|.||.|.             |.|..|.|      |..|...:..|: ..
Mouse   439 IGQDGHQWTVSPLHNNPKGKKSP-------------SLPTGGTQ------DQTRKERKTTPLDDK 484

  Fly   497 YTEPVHSNTSQYV-----QHPKPQFSSGLHKSAKLPVITPAGATVQPTWHSVAERINDFERSQLG 556
            ....||.:.|..:     .||.....:....:::.|..|.:.......:.|..:.::..|.|:.|
Mouse   485 LMASVHQSQSDVLLGEVDGHPNRAGRASSDLTSQQPSATCSSVQQTRDFLSAHKIVDHTEASEEG 549

  Fly   557 EPPKFAYLEPTKTHRL-----SNPALKALQ--KNAVQSYVERQQQQQKEEQQLLRPHSQSYQACH 614
            :.      ||.:..||     ..|..:::|  :.:.:.....:.:.|:.:.||.:......|.|
Mouse   550 DN------EPKECGRLGGRRSGGPRGRSIQNRRRSERFATNLRNEIQRRKAQLQKSKGPLSQLC- 607

  Fly   615 VERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTPPPPPRRSGSLLP---------------NLLR 664
                               .:|.|.......|..||....:.||||               :::.
Mouse   608 -------------------DTNEAVEETQEPPESPPLSASNASLLPSYKNVPSPGDKVFNKSMIL 653

  Fly   665 RSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPPPPPPRGRLAVPTRRTSSATE 729
            |:.|:...::..|..:|:|.|:|                 .|.|.....:..||:.|...:|
Mouse   654 RARSSECLSQASESSKARGGVEG-----------------RMSPGQRSGQSSLALNTWWKAS--- 698

  Fly   730 YAPMRDKLLLQQAAALAH----QQHHPQQHRHAQPPHVPPERPPKHPNLRVPSPELPPPPQSELD 790
                 |...|....|.||    :.|......|...|.|            ..|.|.|..|    |
Mouse   699 -----DSSTLDTEKANAHHGVCRGHWRWSPEHNAQPQV------------ALSTEAPSNP----D 742

  Fly   791 ISYTFDEPLPPPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTAIVAAKVPPLVPK-KP- 853
            .|.......|......||.    |..:||..|..:|...:|...|   .:......|.:.: ||
Mouse   743 DSKELKTSTPQAGEEAVLM----PFADRRKFFEESSKSLSTSHLP---GLTTHNNKPFIQRQKPI 800

  Fly   854 ----TSLQHK----HLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHDNVIASN 910
                .|:.::    |..:....|..:.:||..|..  :..||:....|..|...:|
Mouse   801 DQNFQSVSYRDLRCHPLDQSYHSADQSYHAADQSY--HSLSPLQSETPTYPECFAT--------- 854

  Fly   911 LESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLT---SNEDLVAHTKPSYGVTGKLPNNL 972
                 :.|.||..       .:.:::.|.|   |..|.:   |.:..|.| .|....:|
Mouse   855 -----KGRDNSLC-------CKPVHHGDCD---YHRTCSHPCSAQGTVRH-DPCICCSG------ 897

  Fly   973 PDVLPLGVKLHQQPKLQPGSPNGDANVTLRYGSNNNLTG----------NSPTVAPPPYYGGGQR 1027
             ::.|..:|.:..||..        |....:......||          ...::||    |...:
Mouse   898 -EICPALLKRNLLPKCH--------NCRCHHHQCIRCTGCCHGPQHSAHEDSSMAP----GNAWK 949

  Fly  1028 YSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTMSQSHVDLKQAAHDLETTLEEVLPT 1092
            .....:.:......||:|..:.|.....::.|:                :|...|.
Mouse   950 SRKAAIQEFPVDKWKPITGNRKTSHSGREMAHS----------------KAGFSLS--------- 989

  Fly  1093 ATPTPTPTPTPTPPRL-SPASSHSDCSLSTSSLECTINPIATPIPKP-EAHIFRAEVISTTLNTN 1155
                     ||..|.: :||...|:.. :.|||: .:........|| |:.::..|        |
Mouse   990 ---------TPFRPCIENPALDLSNYR-AVSSLD-ILGDFKRASNKPEESSVYEDE--------N 1035

  Fly  1156 PLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGGYTTPLITSPTASFANEPLMTPP 1220
            .:.:.|:|.  |..:..|:...:....:.....|..::...|..     |.|....|.:.:..||
Mouse  1036 SVASMPRPL--RSRAFSESHISLEPQNTQAWGKHQRESFSKGSE-----TQPDTLGARKKVFPPP 1093

  Fly  1221 LPPSPPPPLEP-------------------------EEEEEQEENDVHDKQPEIEELQLMQRSEL 1260
            .|  |||..|.                         |||||:|:.:..:|:.::.....  .|||
Mouse  1094 RP--PPPNWEKYRLFRAAQLQQQQQQQQQQQQQQRCEEEEEKEQEEEGEKEEDLPPQYF--SSEL 1154

  Fly  1261 VLMVNP----KPSTTDMACQTDELEDRDTDLEAAREEHQTR--------------------TTLQ 1301
            .....|    :|.:..|..|           ||:|:..|:.                    |..|
Mouse  1155 TGSCAPNTEEQPQSLKMGHQ-----------EASRQGSQSLQEQEAFALHPSNFVPPVRGCTVPQ 1208

  Fly  1302 PRQRQ-PIELDYEQMSR--ELVKLLPPGDKIADILTPKICK--PTSQYVSNLYNPDVPLRLAKRD 1361
            |.:.| |.......:.|  |....:.|..:......||...  |||  .|..||    :.:||.:
Mouse  1209 PEKAQHPCYYGTHGLWRTTEQEATVTPKQEFQHFSPPKGASGIPTS--YSAYYN----ISVAKAE 1267

  Fly  1362 VGTSTLMRMKSITSSAE--IRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTI 1424
            :    |.::|.....||  :....|:.:||           ||..:||:.:::|:..|:..|:.:
Mouse  1268 L----LNKLKQQPEMAEAGLGEEGVDYELA-----------QKKIQLIESISRKLSVLREAQRGL 1317

  Fly  1425 SEECSANDRLGQDLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLET----R 1485
            .::.:||..||:::.|.|....:.:|..|:...:..:..:.:||||||.|||:.|::|.:    .
Mouse  1318 LDDINANAALGEEVEANLKAVCKSNEFEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDSES 1382

  Fly  1486 QQERGALESKRDLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADA 1550
            .||:..|..|:..|..|:.:|:.||..::.|...:.|::::.|..|...||.:|:.||:.||.:.
Mouse  1383 NQEKLVLIEKKQQLTNQLADAKELKEHVDGREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQ 1447

  Fly  1551 RDLAVRIKGSEEQLSSLSDAL 1571
            |:|..:||..||||..|.::|
Mouse  1448 RELEEKIKLGEEQLKCLKESL 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	74/259 (29%)
Shroom4	NP_001035549.1	PDZ_signaling	13..89	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..175		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..321		26/152 (17%)
		FAM196	<229..>375	CDD:291917	36/179 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..523		20/109 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..577		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..644		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..688		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..753		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..791		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1022..1041		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1055..1185		30/149 (20%)
		ASD2	1229..1467	CDD:285850	73/258 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847490
Domainoid	1	1.000	109	1.000	Domainoid score	I6349
eggNOG	1	0.900	-	-		E1_28N8R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43196
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930