DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shrm and Shroom2

DIOPT Version :10

Sequence 1:NP_001097307.1 Gene:Shrm / 36592 FlyBaseID:FBgn0085408 Length:1576 Species:Drosophila melanogaster
Sequence 2:NP_766029.2 Gene:Shroom2 / 110380 MGIID:107194 Length:1487 Species:Mus musculus


Alignment Length:1700 Identity:350/1700 - (20%)
Similarity:558/1700 - (32%) Gaps:575/1700 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 LDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHS-HAHSHSNSHGHSHGH 210
            |...|||:..|.:.||    ..|..|......||..|          || ||..:.:.|......
Mouse    82 LSGFRQEAICLVKGSH----KTLKLVVKRKSDPSWRP----------HSWHATKYFDVHPEPAAS 132

  Fly   211 AH-SASSSSSSNNNSNGSATNNNNNNSSESTSSTETLKWLGSMSDISEASHA-----TGYSAISE 269
            .. :.|.|.|..:....|:::::.:.|.|.||...|.....||..|....|:     :|:.:.::
Mouse   133 LFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAK 197

  Fly   270 SVSSSQRI-VHSSR-----------------VPTPKRHHSESVLY---LHNNEEQGDSSPTASNS 313
            |.||...: .||.|                 :|......:|::||   |......|.|..:.|..
Mouse   198 SNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTG 262

  Fly   314 SQMMISEE---------ANGEESP---PSVQPLRIQH--------------RHSPSYPPVHTSMV 352
            ....:.:.         .|..:||   .:|:|....|              :.:||.||:...: 
Mouse   263 DPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPL- 326

  Fly   353 LHHFQQQQQQQQDYQHPSRHHTNQ-----STLSTQSSLLELASPTEKPRSLMGQSHSM--GDLQQ 410
                     :...:...:|.|...     |.|::....:.|  |..:||.    .|.|  .|.|.
Mouse   327 ---------RSDSFSVAARGHEKARGPPFSDLASMQHFITL--PHVQPRG----DHRMETTDRQW 376

  Fly   411 KNPHQNPMLGRSAGQQHKSSISVTISSSEAVVTIAPQP-----------------PAGKPSKLQL 458
            |..|                    :||.:.:..:..|.                 |:|.|.:||.
Mouse   377 KLTH--------------------LSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQF 421

  Fly   459 S--------LGKSEALSCS----------------TPNMGEQSPTNSIDSYRSNHRLFPVSTYTE 499
            |        .|......||                ||..|.|.|.............:|.|.:.:
Mouse   422 SDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQK 486

  Fly   500 PVHSNTSQYVQHPKPQFSSGLHK--SAKLPVITPAGATVQPTWHSVAERINDFERSQLGEPPKFA 562
            ......|.|       |...|.:  .....|:.|.|    ..|||....::              
Mouse   487 LDDRGRSHY-------FPGSLRQPVQGSAQVVIPRG----DYWHSDTTPVD-------------- 526

  Fly   563 YLEPTKTHRLSNPALKAL-QKNAVQSYVERQQQQQKEEQQLLRPHSQSYQACHVERKSLPNNLSP 626
                     |..|.|:.: |:..:|.:.|.....:||....|   :...:.|....:..|.....
Mouse   527 ---------LEYPLLRPVGQRTYLQQHEETPASHEKEGYHQL---NAGIEGCCSGIQEPPRASRT 579

  Fly   627 IMVGLPTGSNS------------------------------ASTRDCSSPTPP-------PPPRR 654
            :..||...||.                              .:::||.:..||       .|.||
Mouse   580 VRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRR 644

  Fly   655 SGSLLPNL----------LRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPP 709
            |......|          |::|.|....|...|.....|..:.               |.|..|.
Mouse   645 SDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRA---------------DVGAVPE 694

  Fly   710 ---PPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPPHVPPERPPKH 771
               |...:..|.....|...||.: ..||   |....  |.|...|.:||               
Mouse   695 GSFPSTYKEHLKEAQTRVLKATSF-QRRD---LDPTP--ADQYSGPSEHR--------------- 738

  Fly   772 PNLRVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPP 836
                                  |||.                          .||:..:::...|
Mouse   739 ----------------------TFDH--------------------------SASSSLSSFPGEP 755

  Fly   837 PTAIVAAKVPPL----VPKKPTS-LQHKHLANGGGGSR-----KRPHHATPQPILENVASPVAPP 891
            .:|      |..    :.|.|:| :...|:...||..|     |...::.|:.|.|...|....|
Mouse   756 DSA------PRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRP 814

  Fly   892 PPLLPRARSTAHDNV---------IASNLESNQQKRSNSKASY-LPRQSLEK-------LNNTDP 939
            .|.:    .|..|.|         .....:|..||..:.:... |||:..|:       ..:|:|
Mouse   815 HPTV----RTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEP 875

  Fly   940 DHGIYKLTL-TSNEDLVAHTKPSYGVTGKLPNNLPDVLPLGVKLHQQPKLQPGSPNGDANVTLRY 1003
              ...|.:| ||..::::..|     ..|....|.....||.....|...:......:|..:.||
Mouse   876 --WFQKRSLATSCGEILSDRK-----VEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRY 933

  Fly  1004 GSNNNLTGNSPTVAPPPYYGGGQRYSTPVLGQGYGKSSKPVTPQQYTRSQSYDVKHTSAVTMPTM 1068
            .|.::                       :|..|..:..:|    ||...:|    .:|..|....
Mouse   934 HSADD-----------------------ILDAGLDQQQRP----QYIHERS----RSSPSTDHYS 967

  Fly  1069 SQSHVDLKQAAHDLETTLEEVLPTATPTPTPTPTPTPPRLSPASSHSDCSLSTSSLECTINPIAT 1133
            .:..|:..:.|.|.....|.:|.|                  ..:...||..:||:      :::
Mouse   968 QEVPVEPNRQAEDSGDHKEAILCT------------------LQAEEGCSAPSSSV------LSS 1008

  Fly  1134 PIPKPEAHIFRAEVISTTLNTNPLTTPPKPAMNRQESLRENIEKITQLQSVLMSAHLCDASLLGG 1198
            ..|:...|:            |..||.|:|.              |||.|  ...||        
Mouse  1009 AQPQDSQHV------------NEDTTFPQPE--------------TQLSS--KCQHL-------- 1037

  Fly  1199 YTTPLIT--SPTASFANEPLMTPPLPPSPPPPLEPEEE-----EEQEEND----------VH-DK 1245
            .|:.:.|  ||:..||.:.|       :..|||...|:     |...:|:          || :.
Mouse  1038 QTSAMETSRSPSPQFAPQKL-------TDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSES 1095

  Fly  1246 QPEIEELQ-LMQRSELVLMVNPKPSTTDMACQTDELEDRDTDLEA-------AREE----HQTR- 1297
            |||.|..| |...:||    .|.||    ..:.|:::...|..:.       .|:|    |:.| 
Mouse  1096 QPEKESRQSLACPAEL----PPLPS----GLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARP 1152

  Fly  1298 ------TTLQPRQR----QPIELDY-------------EQMSRELVKLLPPGDK-IADILTPKI- 1337
                  :|..|..|    .|..|:|             |:::||:|    ..|| :||||.|.: 
Mouse  1153 PEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIV----GKDKSLADILDPSVK 1213

  Fly  1338 CKPTSQYVSNLYN----------------PDVPL-RLA---KRDVGTSTLMRMKSITS------- 1375
            .|.|...:..::.                |.||| |:.   |:|.|...::.:.:.::       
Mouse  1214 IKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAP 1278

  Fly  1376 SAEIRVVSVELQLAEPSE----EPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQ 1436
            .||:.:...:||  ||.|    :..:.:..|..|||..:::|:..|:..::::.|:..||:.||.
Mouse  1279 KAELLIKMKDLQ--EPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGD 1341

  Fly  1437 DLFAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSLETRQQ-----ERGALESKR 1496
            ::.|.:.:..:|:|..|||..:..:..:.:||||||.|||:.|::|.....     :|.:|..|:
Mouse  1342 EVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQ 1406

  Fly  1497 DLLYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSE 1561
            .:|.:|.|:|:.||.:::||...:..:||..||.:..|||::|:.||:.||.:.|:|..:|...|
Mouse  1407 RVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGE 1471

  Fly  1562 EQLSSLSDAL 1571
            |||..|.|:|
Mouse  1472 EQLKCLFDSL 1481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShrmNP_001097307.1 ASD2 1318..1571 CDD:462561 86/290 (30%)
Shroom2NP_766029.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
PDZ_shroom2_3_4-like 25..106 CDD:467232 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..234 8/44 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..299 8/48 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 430..501 13/77 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..643 5/30 (17%)
ASD1 662..840 CDD:462562 47/271 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 717..760 15/117 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..983 9/46 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1092..1118 12/33 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1145..1188 8/42 (19%)
ASD2 1192..1481 CDD:462561 87/294 (30%)
Blue background indicates that the domain is not in the aligned region.

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