DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shrm and shroom1

DIOPT Version :9

Sequence 1:	NP_001097307.1	Gene:	Shrm / 36592	FlyBaseID:	FBgn0085408	Length:	1576	Species:	Drosophila melanogaster
Sequence 2:	XP_002935306.3	Gene:	shroom1 / 100145627	XenbaseID:	XB-GENE-6492080	Length:	1432	Species:	Xenopus tropicalis

Alignment Length:	1763	Identity:	346/1763 - (19%)
Similarity:	585/1763 - (33%)	Gaps:	540/1763 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NHKENGNGSEMGESTKSLAKMEPENNNKISVVSVSKLLLKDSNGANSRSSNSNASFSSASVAGSV 69
            |.|..|..:.:|.|            .:||.:. |...|.||         :.:|||.:|.....
Frog    12 NIKSTGVVAGLGHS------------ERISPIR-SMTTLVDS---------AYSSFSGSSYVPEY 54

  Fly    70 QDDLPHHNSSSSQLGQQHGSSLDQCGLTQAGLEEYNNRSSSYYDQTAFHHQKQPSYAQSEG-YHS 133
            |:...|                |.|        .:|:...||.|.........||....:| ||
Frog    55 QNSFQH----------------DSC--------HFNDEQLSYMDSEYVRAIYNPSVVDMDGVYH- 94

  Fly   134 YVSSSDSTSATPFLDKLRQESDLLSRQSHHWSENDLSSVCSNSVAPSPIPLLARQSHSHSHSHAH 198
                                 |:||  .|..|...||...|::....|     .|.|..|.:...
Frog    95 ---------------------DILS--GHRCSNVALSGRTSSASCDHP-----SQVHQTSPAKLD 131

  Fly   199 SH---------SNSHGHSHGHAHSASSSSS---SNNNSNGSATNNNNNNSSESTSSTETLKWLGS 251
            ::         |.::|.|....|..:.|:|   .|:.:.|...|:
Frog   132 NYLTNLGSDQFSGTYGESINMKHKQNHSNSIYMPNHKAYGLQRNS-------------------- 176

  Fly   252 MSDISEASHATGYSAISESVSSSQRIVHSSRVPTPKRHHSESVLYLHNNEEQGDSSPTASNSSQM 316
                     .||.|::.|   ...::.:.|.....|.:.|.|:..|....|
Frog   177 ---------PTGVSSLQE---KENQMYNQSNYMEIKHYFSRSLDVLQTEGE-------------- 215

  Fly   317 MISEEANGEESPPSVQPLRIQHRHSPSYPPVHTSMVLHHFQQ-QQQQQQDYQHPSRHHTNQSTLS 380
             :..:.:..::.|.....:.::.||.:    .||..|..... |:..:::.:..|.:.|.:..:|
Frog   216 -LKTQTSCTQNLPDEVSCKFRNTHSTN----RTSKDLSKGNDLQKSNEENTERDSPYLTKEGPVS 275

  Fly   381 -------TQSSLLELASPTEKPRS-LMGQSHSMGDLQQKNPHQNPMLGRSAGQQHKSSISVTISS 437
                   .::|...:....:|..| .:|...:.|......|.|:|....|.|         |:..
Frog   276 QGQYASDVRTSFKNIRRSLKKSVSEKIGAHDNKGGCWIMKPGQDPHCYNSEG---------TVKD 331

  Fly   438 SEAVVTIAPQPPAGKPSKLQLSLGKSEALSCSTPNMGEQSPTNSIDSYR---------------- 486
            :|     ..........|.:|:...|:.|.|.:.......|.|:::|..
Frog   332 AE-----YDDVEQWDIRKSRLNTRASQTLYCESNKDASCPPLNALNSKNEVLEADNTLCFQKDAT 391

  Fly   487 -------SNH------RLFPVSTYT-EPVHSNTSQYVQHPKPQFSSGLHKSAKLPV--ITPAGAT 535
                   |.|      :..|:|... |.:...|:..:.|    .:.|.|.:...||  ..||...
Frog   392 VKSIPLLSQHIQQEKSKSHPLSDLNCEKITKATTPMLYH----LAGGRHSAFIAPVHNTNPAKQE 452

  Fly   536 VQPTWHSVAERINDFERSQLGEP-------PKFAYL----------EPTKTHRLSNPALKALQKN 583
            .........||.|:|...|..||       ||...|          |...:..|::.|.:.|
Frog   453 KLKLESKTFERTNNFSILQQTEPRPDNHKFPKNKSLTQLADLHDSAEGGNSGNLNSSAEECL--- 514

  Fly   584 AVQSYVERQQQQQKEEQQLLRPHSQSYQACHVERKSLPNNLSPIMVGLPTGSNSASTRDCSSPTP 648
             :..|:|:.:..||   ::||..|       .:||.|..:| |....|               .|
Frog   515 -MNDYIEKLKVAQK---KVLRETS-------FKRKDLQMSL-PCRFKL---------------NP 552

  Fly   649 PPPPR----RSGSLLPNLLRRSSSASDYAEFRELHQAQGQVKGPSIRNISNAEKISFNDCGMPPP 709
            |..|.    ||.|        ||||::...|.   |.:..|  .|..|..:|||::....|
Frog   553 PKRPTIDHFRSYS--------SSSANEETAFL---QTKNSV--DSTYNKDDAEKVAVTRIG---- 600

  Fly   710 PPPPRGRLAVPTRRTSSATEYAPMRDKLLLQQAAALAHQQHHPQQHRHAQPPHVPPERPPKHPNL 774
                 ||                   |.:.::...|.:.:.....|...|..:...:..|...|.
Frog   601 -----GR-------------------KRITKEQKKLCYSEPEKLDHLGIQKSNFAWKEEPAIANK 641

  Fly   775 RVPSPELPPPPQSELDISYTFDEPLPPPPPPEVLQPRPPPSPNRRNCFAGASTRRTTYEAPPPTA 839
            |         ..|:.|::
Frog   642 R---------EMSDSDVA----------------------------------------------- 650

  Fly   840 IVAAKVPPLVPKKPTSLQHKHLANGGGGSRKRPHHATPQPILENVASPVAPPPPLLPRARSTAHD 904
              |.|:..|..|:.|:..    :|......|:..|......:|...:......|.....|::...
Frog   651 --ANKIKYLESKERTASS----SNLSKTELKQIQHNALVEYMERKTNQRPSSNPQFQMERTSGLP 709

  Fly   905 NVIASNLESNQQKRSNSKASYLPRQSLEKLNNTDPDHGIYKLTLTSNEDLVAHTKPSYGVTGKLP 969
            |....|:.|::....:....||.|:|....::       |..|:|.|:        .:|.|.
Frog   710 NYSEWNIYSSETSSGDGSQKYLRRRSAGASSS-------YDATVTWND--------RFGKTS--- 756

  Fly   970 NNLPDVLPLGVKLHQQPKLQPGSPNGDANVTLRY--------GSNNNLTGNSPTVAPPPYYGGGQ 1026
                   |||.:...:|         .|.|..|.        ||...|.|:||:
Frog   757 -------PLGRRSAVEP---------TAGVQRRSFFDQRTLDGSQERLEGSSPS----------- 794

  Fly  1027 RYSTPVLGQGYGKSS---------KPVTPQQYTRSQSYDVK------HTSAVTMPTMSQSH---- 1072
                  |.|...|||         ....|...:::..|:.:      :|||.|....:...
Frog   795 ------LSQKTSKSSHREQVSYVNMEFLPSALSKNHIYNDRLTVPGDNTSADTERIRASKSRGKS 853

  Fly  1073 ---------VDLKQAAHDLETTLEEVLPTATPTPTPTPTPTPPRLSPASSHSDCSLS-----TSS 1123
                     |.|.:.:|..:.......|..:|....|.|       .|.||.|..|:     |.:
Frog   854 MEEIGTADIVTLAELSHSSDQLYHIKGPVISPRLENTRT-------AAVSHQDNVLASTQNETGN 911

  Fly  1124 L------ECTINPIATPIPK--PEAHIF--RAEVISTTLNTNPLTTPPKP-----AMNRQESLRE 1173
            |      |..:.|..:.:..  .|||.:  ||...|:.:: ||.::||..     |......|..
Frog   912 LPRQTHQESVLGPRRSDLANLGQEAHSWPLRASAASSGID-NPCSSPPSAKVHPWAPEPLHCLDT 975

  Fly  1174 NIEKITQLQ-------SVLMSAHLCDA--------------SLL--GGYTTPLITSPTA--SFAN 1213
            ..|..||..       |....:||.|.              |.|  .|:...||.:..|  |..:
Frog   976 EDEVFTQASTARNEDPSSTALSHLHDIGNPVCEEEDTALCFSFLPEQGHLERLIVNEAAPSSETD 1040

  Fly  1214 EPLM-------TPPLPPSPPPPLEPE----EEEEQEENDVHDKQPEIE---------ELQLMQRS 1258
            |.::       |...||......:|.    |.:|.||.    ::|.:.         ||:.:..|
Frog  1041 EGVLDTAAVNATTTQPPETSEDNKPHGFSAENQEVEEG----REPMLAEFVDSSQQLELRSLPSS 1101

  Fly  1259 ELVLMVNPKPSTTD--MACQTDELEDRDTDLEAAREEHQTRTTLQPRQRQPIELDYEQMSRELVK 1321
            ::.:|...:|...|  .:...|.:|.:..|:|...:|.:.....:.:.:.|    .::...||||
Frog  1102 QVNVMQTTEPYVGDDKSSGNEDSMEQKSQDIEQKSKEPEEEDLPKVKLKSP----EDERREELVK 1162

  Fly  1322 LLPPGDK-IADILTP-KICKPTSQYVSNLYNPDVPLRLAKRDVG------TSTLMRMKS-ITSSA 1377
            .:...|| :.:.|.| .:.:.....:.:|:..|.......|..|      :.||.:..| :.||:
Frog  1163 DIVAKDKSLMNCLQPISVRESAMDLMKSLFPMDFTEAEKSRTRGLLRKDNSETLRKNNSDLESSS 1227

  Fly  1378 EI-RVVSVELQLA---EPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDL 1438
            :: ..::|.||.:   .|..|..:.|..|..||:.::..|:..|..:::.:..:.|.|...|.::
Frog  1228 KLPSKITVMLQKSSARRPDGESLDDITSKKMELLSNIGSKLEDLCEQKEILLADNSKNTTHGNNI 1292

  Fly  1439 FAKLAEKVRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQERGALESKRDL 1498
            .|.:.|..:|:|..::...:..:..:.|||.|||.||.:.|::|     .|..:|..:|:.:.:|
Frog  1293 QALVKELCKPNEFERYMMFIGDLEKVVSLLFSLSTRLTRVENALSKVDENTDAEEMQSLKERHNL 1357

  Fly  1499 LYEQMEEAQRLKSDIERRGVSIAGLLAKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQ 1563
            |..|.|:|:.||::::||...:.|:|.|.|:.:...||.:|:.:|..|:.:.::|..:||..|||
Frog  1358 LSSQREDAKDLKANLDRREQVVTGILVKYLNEEQLQDYKHFVRLKTSLLIEQKNLEEKIKLYEEQ 1422

  Fly  1564 LSSLSDAL 1571
            |.|:.|::
Frog  1423 LESIHDSI 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shrm	NP_001097307.1	ASD2	1318..1570	CDD:285850	74/269 (28%)
shroom1	XP_002935306.3	ASD1	481..644	CDD:400846	48/242 (20%)
shroom1	XP_002935306.3	ASD2	1159..1429	CDD:400845	74/269 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5831
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004714
OrthoInspector	1	1.000	-	-		otm48335
Panther	1	1.100	-	-	LDO	PTHR15012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.100