DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and tdrd5

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_031756124.1	Gene:	tdrd5 / 780220	XenbaseID:	XB-GENE-5884032	Length:	1010	Species:	Xenopus tropicalis

Alignment Length:	749	Identity:	143/749 - (19%)
Similarity:	248/749 - (33%)	Gaps:	246/749 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTVTGHGQM--- 71
            ::|.|.:|:::|...|::.:|.:|||...|..:|...||:|.....|..:|..|.:  |.|:
Frog    57 IQKDVRALLIASKNGLSIHELEQDYRMMIGSHIPIRSLGYKSTMELLLDMPSVVKI--HTQLDGT 119

  Fly    72 AWITAVATAKSAHIQKLVRCQK-----KSKNRGSHKPKYCYASEPSNLVFINESVSKMKNRKAPF 131
            ..::||....:..|..||.|||     :::||..:....|    |.:||        .:.|.:|.
Frog   120 VKLSAVVDETTRRIADLVSCQKDRCTARTRNRRRNIRPRC----PVDLV--------RRGRVSPV 172

  Fly   132 PTYQVPRNLK--LPVS-----------------------YPNYNRL------------------- 152
            ....|..:|:  |.||                       |..|:.|
Frog   173 LPATVKSDLRDLLSVSPLLLSELEKAFSSRFGRSFQYTRYGFYSMLEVLRSITDIVEVKQTRAGS 237

  Fly   153 ---LYPVHTPHIDQMISTGQQQSTLRTQR-----------PSFPCNANSKS---LKVN--DWSQK 198
               |....|..|...:...|.|..:..::           |..|....|::   |||:  :..:.
Frog   238 LLVLRNSETGRISASLCVKQSQLAIDPKKTSCVLEQCLKEPRTPEKKTSETVTYLKVSPPEPQKL 302

  Fly   199 DRKQEPSKERNNQKYPKITTENKQE------------KETEELAQAFENLSVDV----------- 240
            ..|:.||..|:..  |.|.:.||::            |..|..|....|.:..|
Frog   303 SSKESPSVTRSTS--PLINSSNKEQRLKLNVLLDESLKSNENKAPPVTNFTSAVPSHNSVLSNSL 365

  Fly   241 ---------------APTDHQEKLKCEIYEDNEDEFVRDPFIYGEVKEKEDEAVVL------AFD 284
                           .||.|.|       .|:......|..:...:::|.::.:.|      |..
Frog   366 VGNSVSSETLFTKMSRPTSHVE-------ADHSAASEPDASVLEWLEKKLEKELKLCLARKGAGG 423

  Fly   285 AVSE--------------DGFDLLSMTTTQQNAV-KPLDPPE--------------DCLHYASSD 320
            :||:              ||..:..:.|..::.. |.|...|              |.|...|:.
Frog   424 SVSDALRMDIQHVVNQHSDGLKISQLPTVFKSFTGKDLPFKELGFISVMELVGSLGDILCVESTV 488

  Fly   321 DGED---------------ENAIPAYA-------------------------VDHRVL------- 338
            ||:|               ...:|:.:                         ||.::.
Frog   489 DGKDWKLFDAKKKDLVDEFSAGLPSTSSILSSWNSSQQTTTPVKPVGTIFSKVDEKLWWGPLELK 553

  Fly   339 -----DVDYPRDAVRS--AFTLPARDIESIIELQQRIRVQLVSLVNPHNFNFWIY-----NDDFK 391
                 .:|.|.||||:  ...||:      ::....|.|.:.::.:|..|    |     .|..:
Frog   554 LCSTEQIDIPPDAVRNQKLHCLPS------MKRGFMIGVYVENIESPSQF----YVRCCGKDTSE 608

  Fly   392 DYEAQFANMQTFYESSE--SKNYTMPLFLITTDHLCVVRCTSG--WERAKVLGYRSSNNKMTIEV 452
            ..|.....|:..| |:|  |:.|.:....|:...:..:|....  |.|..|   ....|...::|
Frog   609 KLEDMMIEMRHCY-SNECVSERYIVTDNCISVGQIYALRVPGDVWWYRVIV---HDIKNSELLDV 669

  Fly   453 ELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRLLYA 517
            ...|.|::..|.:..::||...:..:|.|.:...|.::|..:. .|:|:.:..|..:.....|..
Frog   670 FYPDFGNVATVKKSWLRFLKNCYMKIPAQAVPSSLPYVTSTED-QWSAQAIKKFQQLCSCIPLVG 733

  Fly   518 KVEAIKNNTAYLVLVDTESQGHTVNLNRSLIETG 551
            .|.....:..::.|.||.|: ..:.|::.||..|
Frog   734 MVLQYVQDILHIFLCDTSSE-EDLYLHQLLISQG 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	25/85 (29%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	24/117 (21%)
tdrd5	XP_031756124.1	LOTUS_1_TDRD5	50..142	CDD:193599	26/86 (30%)
		LOTUS_2_TDRD5	174..242	CDD:193589	8/67 (12%)
		LOTUS_3_TDRD5	426..499	CDD:193590	13/72 (18%)
		Tudor_TDRD5	587..704	CDD:410490	25/124 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I5032
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115068at2759
OrthoFinder	1	1.000	-	-		FOG0006089
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060