DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tej and Tdrd6

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001178512.1	Gene:	Tdrd6 / 316254	RGDID:	1305956	Length:	2136	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	117/609 - (19%)
Similarity:	204/609 - (33%)	Gaps:	188/609 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELSLVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTVTGHG- 69
            ||.|.:.|..||..|         |::.|.:..|       ||...|....|:.|.    ..|.
  Rat   193 ELGLARHVPDSLFCS---------LLKRYLTAAG-------LGSSGAPVLPRAAPK----QEHPG 237

  Fly    70 --------QMAWITAVATAKSAHIQKLVRCQKKSKNRGSHKPKYCYASEPSNLVFINESVSKMKN 126
                    |:.....|...:..|..: :.||.:|.::..|:              ::||::::
  Rat   238 LDYFYPQLQLGVTEPVVVTQVCHPHR-IHCQLRSLSQEIHR--------------LSESMAQV-- 285

  Fly   127 RKAPFPTYQVPRNLKLPVSYPNYNRLLYPVHTPHIDQMISTGQQQSTLRTQRPSFPCNANSKSLK 191
                   |:.|..                  |...|...:|.:::.. ...:|..||
  Rat   286 -------YRAPTG------------------TEDEDSGSATWEEREE-SPDKPGSPC-------- 316

  Fly   192 VNDWSQKDRKQEPSKERNNQKYPKITTENKQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYED 256
                        .|...:.|.|..:..|..:.:...::      |.||..   .:|.:.|.....
  Rat   317 ------------ASCGLDGQWYRALLLETFRPQRCAQV------LHVDYG---RKELVSCSSLRY 360

  Fly   257 NEDEFVRDPFI--------------------YGEVKEKEDEAVVL------------AFDAV--- 286
            ...|:.|.|.:                    .|::|     |::|            :|:.:
  Rat   361 LLPEYFRMPVVTYPCALYGLWDCGRGWSRSQVGDLK-----ALILGQAVNAKIEFYCSFEHMYYV 420

  Fly   287 ---SEDGFDLLSMTTTQQNAVKPLDPPEDCL--HYASSDDGEDENAIPAYAVDHRVLDVDYPRDA 346
               .|||.:|.|....|          ..||  .:..|...|:|.              |...|.
  Rat   421 TLYGEDGINLNSAFGVQ----------SCCLADRFLQSQGIEEEE--------------DEDEDE 461

  Fly   347 VRSAF--TLPARDIESIIELQ--QRIRVQL-------VSLVNPHNFNFWIYNDDFKDYEAQFANM 400
            :.:||  ..||.::|..:.|.  :.||:::       |..|...: .|||.....|:..::....
  Rat   462 MEAAFQSQSPAEEMEEEVSLPSLRSIRLKMNTFYDAQVEFVKSPS-EFWIRLRKHKNTFSKLTKR 525

  Fly   401 QTFYESSESKNYTMPLFLITTDHLCVVRCTSGWERAKVLGYRSSNNKMTIEVELVDIGDIIRVSQ 465
            ...:.||.||...:.|.....|..||....:|:.||.|....|.    :::|.|||.|:...|..
  Rat   526 MCSFYSSASKLDGVILKPEPDDLCCVKWKENGYYRAMVTRLDSK----SVDVFLVDRGNSENVDW 586

  Fly   466 QNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRLLYAKVEAIKNNTAYLV 530
            .:|:.|:..|..||...|...||.|... ...|:.|.::||...:|.:.|...: ..|.:..|::
  Rat   587 CDVRMLLPQFRQLPILALKCTLADIWPL-GKTWSQEAISFFKKTVLHKELVVHI-LDKQDRQYVI 649

  Fly   531 LVDTESQGHTVNLNRSLIETGWVR 554
            .:..||:....|:::.:.:.|:.:
  Rat   650 EILDESRTGEENISKVIAQAGYAK 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	19/94 (20%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	29/108 (27%)
Tdrd6	NP_001178512.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965	29/205 (14%)
		TUDOR	313..359	CDD:119391	11/74 (15%)
		TUDOR	489..610	CDD:278965	32/125 (26%)
		TUDOR	547..591	CDD:119391	15/47 (32%)
		TUDOR	775..891	CDD:278965
		TUDOR	827..870	CDD:119391
		TUDOR	988..1107	CDD:278965
		TUDOR	1043..1085	CDD:119391
		TUDOR	1310..1429	CDD:278965
		TUDOR	1363..1407	CDD:119391
		TUDOR	1523..1645	CDD:278965
		TUDOR	1578..>1616	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900